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  • 1
    Electronic Resource
    Electronic Resource
    Early rheumatoid arthritis —onset, course, and outcome over 2 years (1990)
    Springer
    Rheumatology international 10 (1990), S. 135-142 
    Details
    ISSN: 1437-160X
    Keywords: Early RA ; HAQ ; SOFI ; Radiology ; Anxiety ; Depression ; Outcome ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eighty-nine patients, 33 men and 56 women, with early definite rheumatoid arthritis were followed for 2 years. Two-thirds were seropositive. About 1/3 were eventually treated with second line drugs. The disease mostly had an insidious onset initially involving the finger joints. Early remission occurred in 16%. Patient relevant measures such as pain, patient's overall assessment of disease activity and anxiety decreased significantly. Disability evaluated by the HAQ disability index remained at a low level. The joint damage score (JDS) in hands and feet increased steadily and only 18% were nonerosive after 2 years. One-third developed hand deformities which was associated with higher JDS. A joint function index (SOFI) correlated significantly with JDS. Twenty-eight percent had a slower rate of joint damage progression the second year. There was no significant correlation between JDS and disease duration. Six patients developed rapidly progressive damage in larger joints, five in the hip joints and one in the shoulder joint, all requiring joint replacement. The ability to predict outcomes with clinical and laboratory variable obtained at entry was of limited clinical usefulness. By applying discriminant analyses 67%–80% of the cases who fared worst regarding clinical, functional, and radiological features could be correctly classified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274837
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mononuclear cells recovered from inflammatory synovial membrane using fine-needle biopsy (1988)
    Springer
    Rheumatology international 8 (1988), S. 101-105 
    Details
    ISSN: 1437-160X
    Keywords: Arthritis ; Synovia ; Biopsy ; Mononuclear cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A simple technique for fine-needle aspiration biopsy from the synovial membrane of arthritis knee joints preceded by lavage of the joint cavity is described. The procedure was atraumatic, well accepted, and could be performed on outpatients. Cells originating from the synovial membrane were obtained in 12 of 17 knees using a 1.2-mm cannula. The yield was 6.0×103 to 135×103 mononuclear cells. The cell populations could be expanded by stimulation with antigen and mitogen. The described fine-needle biopsy technique is of value when repeated sampling of synovial membrane cell populations is desired.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00272430
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Antigenic heterogeneity among monoclonal IgM: Observations on guinea-pig sera (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1229-1230 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antisera against purified monoclonal IgM from patients with Waldenström's macroglobulinemia were raised in guinea-pigs. Absorption with normal human serum and heterologous macroglobulinemic serum resulted in an antiserum to a subgroup present in 5 of 54 sera.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326808
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Intraarticular corticosteroid injection into rheumatoid arthritis knees improves extensor muscles strength (1990)
    Springer
    Rheumatology international 9 (1990), S. 265-270 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Synovitis ; Knee joint ; Extensor torque ; Local corticosteroid ; EMG ; Synovial fluid volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Eleven arthritic knee joints in seven patients with rheumatoid arthritis were studied before and after intraarticular injection of a corticosteroid preparation. Extensor muscle torque and quantitative electromyography increased on days 7 and 14 after treatment, indicating that muscle function had been inhibited by synovitis. Clinical signs of synovitis, such as pain, range of motion and knee circumference, also improved. Synovial fluid withdrawal alone improved extensor muscle torque. Joints with instability and/or radiological cartilage involvement also improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541322
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical and methodological studies on intramuscular ketoprofen in postoperative rheumatic pain (1981)
    Springer
    European journal of clinical pharmacology 20 (1981), S. 423-425 
    Details
    ISSN: 1432-1041
    Keywords: ketoprofen ; rheumatoid arthritis ; mass fragmentography ; plasma levels ; postoperative pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ketoprofen (Kp), given intramuscularly to 15 patients with chronic arthritis on the day after elective joint surgery (13), or during bouts of extreme pain (2), resulted in satisfactory pain relief, and seemed able to replace opiates. A new assay method for plasma Kp, based on gas chromatography/high resolution mass fragmentography is described, which permits determination of Kp even in the presence of probenecid. Kp was rapidly absorbed and peak plasma levels of 10.2 to 18.6 μmol/l were attained within 30 min. Probenecid did not interfere with the elimination of Kp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542094
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    Paper (German National Licenses)
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