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  • 1
    Electronic Resource
    Electronic Resource
    CORRELATIONS BETWEEN A FLUORIMETRIC and MASS FRAGMENTOGRAPHIC METHOD FOR THE DETERMINATION OF 3-METHOXY-4- HYDROXYPHENYLACETIC ACID and TWO MASS FRAGMENTOGRAPHIC METHODS FOR THE DETERMINATION OF 3-METHOXY-4- HYDROXYPHENYLETHYLENE GLYCOL IN CEREBROSPINAL FLUID (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One-hundred and twenty-two lumbar cerebrospinal fluid (CSF) samples were assayed for 3-methoxy-4-hydroxyphenylacetic acid (HVA) by both a fluorimetric and mass fragmentographic method. The correlation coefficient (cc) and residual standard deviation (Syx) of the results were calculated as 0.966 and 23.3 ng/ml, respectively. If only samples containing less than 100ng/ml of HVA were considered, somewhat different values for cc and Syx were found (0.854 and 10.0 ng/ml, respectively). The data obtained by the fluorimetric method were consistently 17% lower than those obtained by the mass fragmentographic method. Spiking experiments resulted in 96.5 ± 7.8% recovery for the fluorimetric method, whereas the use of a deuterated internal standard was found to compensate completely for losses in the mass fragmentographic method. In addition the correlation between two different mass fragmentographic methods for the simultaneous determination of HVA and 3-methoxy-4-hyd-roxyphenylethylene glycol (MOPEG) in CSF was studied. The measurements were performed in different laboratories and resulted in correlation coefficients of 0.941 and 0.940 and residual standard deviations of 7.6 and 1.0 ng/ml for HVA and MOPEG, respectively. From all data we conclude that mass fragmentographic methods for the determination of catecholamine metabolites in CSF are superior to fluorimetric methods because of their selectivity, reproducibility and accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb04527.x
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  • 2
    Electronic Resource
    Electronic Resource
    IDENTIFICATION AND QUANTIFICATION OF 3-METHOXY -4-HYDROXYPHENYLLACTIC ACID (VLA) IN CEREBROSPINAL FLUID AND 3-METHOXY-4-HYDROXY PHENYLPYRUVIC ACID (VPA) IN THE URINE OF PARKINSONIAN PATIENTS TREATED WITH L-DOPA (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The identification and quantification of 3-methoxy-4-hydroxyphenyllactic acid in cerebrospinal fluid, and 3-methoxy-4-hydroxyphenylpyruvic acid in the urine of Parkinsonian patients on medication with l-3,4-dihydroxyphenylalanine with or without a peripheral decarboxylase inhibitor are described. Data are also given for other catecholamine- and catecholamine precursor metabolites in urine and cerebrospinal fluid. Analyses were performed by means of gas chromatography with flame ionization or mass spectrometric detection. We have concluded that following the administration of l-3.4-dihydroxyphenylalanine + peripheral decarboxylase inhibitor. 3-methoxy-4-hydroxyphenyllactic acid must be considered as a quantitatively important metabolite of L-3.4-dihydroxyphenylalanine in cerebrospinal fluid. In addition, some comment is given on the presence of 3-methoxy-4-hydroxy-phenylpyruvic acid in the urine of these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb06253.x
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  • 3
    Electronic Resource
    Electronic Resource
    Gamma-aminobutyric acid determination in human cerebrospinal fluid by mass-fragmentography (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10802.x
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  • 4
    Electronic Resource
    Electronic Resource
    Excretion of (sulfated) steroids in the urine and excretion of cholesterol sulfate in the feces of boys with recessive X-linked ichthyosis (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 364-369 
    Details
    ISSN: 1432-069X
    Keywords: Recessive X-linked ichthyosis ; Microsomal sulfatase deficiency ; Cholesterol sulfate excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The excretion of sulfated steroids was investigated in the urine and feces of six boys aged 9 months to 7 years and 10 months who had recessive X-linked ichthyosis. Profiles of urinary total steroids as well as sulfated steroids were normal. Cholesterol sulfate excretion in the urine was not elevated. In the feces 2–20% of total cholesterol was cholesterol sulfate, whereas in the feces of 28 healthy children no cholesterol sulfate was demonstrable. In the 6 patients total cholesterol excretion (500–2,500 μmol/kg feces) was also elevated in comparison with the 28 healthy controls (150–700 μmol/kg feces, mean 365 μmol/kg feces)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413356
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  • 5
    Electronic Resource
    Electronic Resource
    Structure of Papain (1968)
    [s.l.] : Nature Publishing Group
    Nature 218 (1968), S. 929-932 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A three-dimensional X-ray study at a resolution of 2.8 Å has revealed that the single polypeptide chain of 211 residues is folded into two distinct parts which are divided by a cleft. The active site, consisting of a cysteine and a histidine, lies at the surface of the cleft. Apart from four ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/218929a0
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  • 6
    Electronic Resource
    Electronic Resource
    Correlation between urinary levels of histamine metabolites in 24-hour urine and morning urine samples of man: Influence of histamine-rich food (1989)
    Springer
    Inflammation research 27 (1989), S. 205-207 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, we have determined and correlated the excretion of the 2 most important histamine metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, in 24-hour urine and morning urine samples of 14 normal healthy persons. We found no significant difference between morning urine and 24-hour urine samples, provided that the subjects were on a histamine-poor diet for at least 24 hours. We also studied the influence of the consumption of histamine-rich foodstuffs on the reliability of these parameters. The morning urinary Nτ-methylhistamine excretion is less affected by histamine-rich foodstuffs and therefore proposed to be the most reliable parameter for endogeneous histamine release.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222240
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  • 7
    Electronic Resource
    Electronic Resource
    Urinary excretion of histamine and some of its metabolites in man: Influence of the diet (1984)
    Springer
    Inflammation research 15 (1984), S. 189-194 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined in 10 normal subjects on 3 different diets, containing a very low protein, a low protein and a high protein amount. Foodstuffs which could contain histamine were excluded. The mean excretion ofN τ-methylhistamine on the second day of each diet amounted to 0.861 μmol/24 h, 1.051 μmol/24 h and 1.378 μmol/24 h, respectively. The excretions of histamine andN τ-methylimidazoleacetic acid were not affected. In 6 normal persons on a protein low diet, the excretions of histamine,N τ-methylhistamine andN τ-methylimidazoleacetic acid have been determined for 10 days. On the fifth day, to 3 persons 200 μmol of histamine was given orally, the other 3 persons received a high protein diet. The persons receiving histamine showed a strongly enhanced excretion ofN τ-methylimidazoleacetic acid, corresponding to 36.1% of the administered histamine, whereas the urinary excretions of histamine andN τ-methylhistamine were only slightly elevated. On the high protein diet, only the excretion ofN τ-methylhistamine was slightly elevated. The urinary excretions of histamine in the female subjects sometimes showed unexpectedly high values. Most probably, this phenomenon is attributable to bacterial histamine production in the urogenital tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972348
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions (1985)
    Springer
    Inflammation research 16 (1985), S. 76-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983105
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites (1984)
    Springer
    Inflammation research 15 (1984), S. 238-241 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Urinary excretions of histamine, Nt-methylhistamine and Nt-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of Nt-methylhistamine and Nt-methylimidazoleacetic acid decreased to a small though significant degree (about 15–20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972355
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  • 10
    Electronic Resource
    Electronic Resource
    Histamine metabolism after adverse reactions due to d-tubocurarine administration (1987)
    Springer
    Inflammation research 21 (1987), S. 54-61 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated histamine release in five female patients, submitted for gynaecological surgery, after intravenous administration of the neuromuscular blocking agent d-tubocurarine. In these patients we measured the plasma levels of histamine and its metabolites, Nτ-methylhistamine and Nτ-methylimidazoleacetic acid, making use of mass fragmentographic methods. The newly developed determination of plasma Nτ-methylimidazoleacetic acid had a within-day coefficient of variation of 2.7% (n=10). Normal values of Nτ-methylimidazoleacetic acid in plasma ranged from 41.3–75.6 nmol/l (n=13). All five patients developed anaphylactoid reactions: two patients showed severe systemic reactions, one patient a minor systemic reaction and two had skin reactions only. Plasma histamine and Nτ-methylhistamine levels appeared to be the most reliable biochemical parameters for confirming both the occurrence and severity of an anaphylactoid reaction. In comparison with plasma histamine, the determination of plasma Nτ-methylhistamine is less hampered by artefacts caused by blood collection and plasma preparation. Together with the fact that the increase in plasma Nτ-methylhistamine levels after anaphylactoid reactions lasts much longer than the increase in plasma histamine levels, this leads to the conclusion that the determination of plasma Nτ-methylhistamine is a useful retrospective parameter for histamine release in this type of pathological state. The plasma Nτ-methylimidazoleacetic acid levels fluctuated considerably, showing only a significant increase after administration of d-tubocurarine in the two patients who had severe anaphylactoid reactions. This parameter is, therefore, less useful in such studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01974921
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