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  • 1
    Electronic Resource
    Electronic Resource
    Primary cerebellar extramedullary myeloid cell tumor mimicking oligodendroglioma (1997)
    Springer
    Acta neuropathologica 94 (1997), S. 398-402 
    Details
    ISSN: 1432-0533
    Keywords: Key words Extramedullary myeloid cell tumor ; Granulocytic sarcoma ; Chloroma ; Oligodendroglioma ; Cerebellum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Extramedullary myeloid cell tumors (EMCTs) are tumors consisting of immature cells of the myeloid series that occur outside the bone marrow. Most of them are associated with acute myelogenous leukemia or other myeloproliferative disorders, and a small number occur as primary lesions, i.e., are not associated with hematological disorders. Occurrence inside the cranium is rare, and there has been only one case of primary EMCT involving the cerebellum reported in the literature. The case we report here is a blastic EMCT occurring in the cerebellum of a 3-year-old boy who had no signs of leukemia or any hematological disorder throughout the entire course. The cerebellar tumor was at first misdiagnosed as an “oligodendroglioma” because of the uniformity and “fried egg” artifact of the tumor cells. The tumor disappeared during chemotherapy consisting of 12 treatments. However, it recurred and metastasized to the cerebrospinal fluid (CSF) shortly after the therapy was completed. A diagnosis of EMCT was suspected because of the presence of immature myeloid cells in the CSF, and was confirmed by anti-myeloperoxidase and anti-lysozyme immunoreactivity of the cerebellar tumor. The patient succumbed 1 year and 3 months after the first presentation of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050725
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  • 2
    Electronic Resource
    Electronic Resource
    Familial neurofibromatosis 1 with germinoma involving the basal ganglion and thalamus (1995)
    Springer
    Child's nervous system 11 (1995), S. 456-458 
    Details
    ISSN: 1433-0350
    Keywords: Neurofibromatosis 1 ; Intracranial ; Germinoma ; Autosomal disorder
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intracranial germinoma associated with neurofibromatosis 1 (NF-1) has never been documented previously. We report a case of familial NF-1 with a germinoma involving the right basal ganglion and thalamus. A 12-year-old boy presented with multiple café-au-lait spots and a family history of neurofibromatosis in his mother, one of two siblings, and his maternal grandfather. His intracranial lesion was subtotally resected. Histologically, it was a pure germinoma. Serum α-feto protein and β-human chorionic gonadotropin levels were within the normal range. Postoperative myelographic examination and cerebrospinal fluid cytology study showed no evidence of subarachnoid seeding. The patient received postoperative combination chemotherapy resulting in complete response and clearance of the residual tumor. Although this finding of an intracranial germinoma in a patient with familial NF-1 may be coincident, it is suggestive of a potential genetic predisposition. Longitudinal evaluation for the possibility of neoplasm, especially germ cell tumor, in basal ganglion lesions in NF-1 patients is necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334965
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  • 3
    Electronic Resource
    Electronic Resource
    Congenital cerebral primitive neuroectodermal tumor with astrocytic differentiation and extracranial metastases (1990)
    Springer
    Child's nervous system 6 (1990), S. 179-182 
    Details
    ISSN: 1433-0350
    Keywords: Primitive neuroectodermal tumor ; Extracranial metastases ; Astròcytic differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A cerebral primitive neuroectodermal tumor with astrocytic differentiation and extracranial metastases in a 28-day-old infant is reported. The infant presented with a progressively enlarged head, cutaneous lesions in the neck, and enlarged cervical lymph nodes. A computed tomography brain scan demonstrated a giant thalamic tumor with subarachnoid dissemination and hydrocephalus. Biopsy material from the cervical lesions showed a picture of glioma with anaplastic astrocytes. The patient received a ventriculoperitoneal shunt operation and palliative chemotherapy, but died at 3 months of age. Autopsy was performed. Histological studies, which included immunohistochemical stains of the thalamic tumor, showed small, round, primitive, neoplastic cells with focal astrocytic differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308497
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  • 4
    Electronic Resource
    Electronic Resource
    Choroid plexus tumors in childhood (1991)
    Springer
    Child's nervous system 7 (1991), S. 437-441 
    Details
    ISSN: 1433-0350
    Keywords: Choroid plexus tumor ; Immunohistochemistry ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Choroid plexus tumors are rare and account for only 2.3% (8/352) of primary childhood intracranial neoplasms in our series. Most of our patients were under 2 years of age. The tumors had a predilection for the lateral ventricle. Calcification was found in half of these tumors, and ossification was seen in 1 case. Histological features of malignancy including invasion, loss of differentiation, and severe nuclear pleomorphism pointed to a poor prognosis. Such features were found in 2 cases. Neither a large number of mitoses nor necrosis was a constant feature in cases of malignancy. Transthyretin, a marker for choroid plexus tumors, was positive in all cases. However, negative S-100 or positive carcinoembryonic antigen was not necessarily associated with a more aggressive histological pattern. All the papillomas could be totally resected without recurrence, and all the patients with carcinoma died within a few months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263185
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  • 5
    Electronic Resource
    Electronic Resource
    A method of enlarging the opening of the third ventricular floor for flexible endoscopic third ventriculostomy (1996)
    Springer
    Child's nervous system 12 (1996), S. 396-398 
    Details
    ISSN: 1433-0350
    Keywords: Pineal tumor ; Neuroendoscopy ; Hydrocephalus ; III Ventriculostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the Pediatric Neurosurgical Service of the Veterans General Hospital, Taipei, flexible endoscopic III ventriculostomy has been applied in children with noncommunicating hydrocephalus and periaqueductal/pineal tumor. We modified the technique to allow enlargement of the opening of the III ventricular floor. The use of an Atlas Wire Stone Extractor for this purpose is described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395093
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  • 6
    Electronic Resource
    Electronic Resource
    Congenital dermoid cysts of the anterior fontanelle in Chinese children (1986)
    Springer
    Child's nervous system 2 (1986), S. 175-178 
    Details
    ISSN: 1433-0350
    Keywords: Anterior fontanelle ; Dermoid cyst ; Children ; Chinese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eight cases of congenital dermoid cysts over the anterior fontanelle have been encountered in Chinese children at the Veterans' General Hospital, Taipei, in the past 4 years. This is the largest series of this anomaly reported in a Chinese population. These children were 3 months to 13 years old, with a female-to-male ratio of 5:3. All of the cysts presented with a nontender subgaleal mass over the anterior fontanelle. The size of these cysts ranged from 1 to 5 cm. The contents of the cysts were pasty and semisolid. In CT scan studies and at surgery, the cysts showed no intracranial extension. Simple surgical excision was adequate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706806
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  • 7
    Electronic Resource
    Electronic Resource
    Brain abscesses in children — a cooperative study of 83 cases (1989)
    Springer
    Child's nervous system 5 (1989), S. 19-24 
    Details
    ISSN: 1433-0350
    Keywords: Brain abscess ; Congenital heart disease ; Infant ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study reviews our experience in 83 cases of brain abscesses in children diagnosed at seven teaching hospitals during the 10-year period from June 1978 to July 1987. The average age of the patients was 7 years, with 12% of them less than 1 year old. The male-to-female ratio was 1.7:1. Of the brain abscesses, 90.4% were detected by CT brain scan. A total of 50.6% patients had congenital heart disease, and 20.4% patients had sepsis and/or meningitis. Only 6% cases had ear, nose, and throat infection. Sixty-eight (81.9%) patients received a combination of antibiotics and surgical treatment. The cerebral abscesses were totally excised in 26 cases, aspirated and partially excised in 6, and aspirated in 32. Sixty patients had pus cultures from the cerebral abscesses. Organisms were isolated in 29 (49.2%) of them. Streptococcus was by far the most common organism. The overall outcome was: 49 (59%) alive; 16 (19.3%) dead; 18 (21.7%) lost to follow-up. Among the 16 mortalities, the causes of death were due to failure to treat the diseases causing the brain abscesses. We had a better outcome in patients whose cerebral abscesses were totally excised or whose abscesses were aspirated, and in patients who were older than 1 year of age.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00706741
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  • 8
    Electronic Resource
    Electronic Resource
    Preirradiation chemotherapy for very young children with brain tumors (1993)
    Springer
    Child's nervous system 9 (1993), S. 150-153 
    Details
    ISSN: 1433-0350
    Keywords: Brain tumor ; Neuroaxis radiation ; Chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Standard management of malignant brain tumors includes either surgical resection alone or surgery followed by irradiation. However, neuroaxis irradiation administered to very young children for primary intracranial tumors is often associated with major late side effects. To delay irradiation and evaluate the efficacy of preirradiation chemotherapy, we treated 9 young children (aged less than 3 years), who had newly diagnosed brain tumors and underwent total or subtotal resection, with a combination of chemotherapy including vinblastine, cisplatin, and etoposide every 3–4 weeks for 6–14 courses between 1988 and 1992. There were malignat gliomas in four patients, medulloblastomas in three, and ependymomas in two. A response to preirradiation chemotherapy (complete remission or partial remission) occurred in seven out of nine cases. Only one patient had progressive disease during the chemotherapy period. Preirradiation chemotherapy with vinblastine, cisplatin, and etoposide might be a highly effective combination allowing delay of radiation therapy in very young children with brain tumors. Acute and subacute toxicity of chemotherapy in this study was mild.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00272265
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