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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of desmosomes in acne vulgaris (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Desmosomes contribute towards adhesion beween adjacent keratinocytes. In acne vulgaris, increased intercellular adhesion is thought to contribute to the retention of keratinocytes within the follicular lumen during comedogenesis. Therefore, the distribution of different desmosomal components was investigated in normal and acne subjects. Biopsies were cryostat-sectioned (6 μm), and stained with antibodies to different desmosomal components: desmoplakin 1/2, desmoglein 1, desmocollin 3a/3b, and a late desmosomal antigen, G36–19. Desmoplakin 1/2, desmoglein 1 and desmocollin 3a/3b shared a similar distribution in follicles from control skin, from acne-affected skin, and in non- intlamed lesions. All three proteins were expressed around the periphery of keratinocytes of all the intrafollicular epidermis, except the basal lamina and the upper stratum corneum. In inflamed lesions, the expression of desmoglein 1 and desmocollin 3a/3b was diminished; in 12.5%, staining for these two proteins was completely abolished, and in 81.25% of the lesions investigated the staining was patchy. The antibody G36–19 bound to an antigen in the upper granular layer in the infundibular epidermis. No differences were noted in the staining pattern of the follicular epithelia of controls, non- inflamed, and inflamed lesions. This study, using monoclonal antibodies, did not identify any changes in the desmosomal components which might explain the increased adhesion between follicular keratinocytes during comedogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb03410.x
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  • 2
    Electronic Resource
    Electronic Resource
    Use of autografts for the treatment of leg ulcers in elderly patients (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 18 (1993), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Human keratinocytes obtained from seven elderly patients who had long-standing leg ulcers of venous or rheumatoid origin were grown into sheets for autografting on to their ulcers on at least one and, in some cases, two occasions. Following the application of the autografts on to the ulcers the appearance of the ulcer base improved with an increase in the vascularity of the granulation tissue and decrease in the amount of exudate. An‘edge effect’was also noted in five cases, with the previously indolent-looking edge of the ulcer appearing healthier and more active. However, over a 4-month follow-up period there was no complete re-epithelialization in any of the ulcers despite these initial improvements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1993.tb02240.x
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  • 3
    Electronic Resource
    Electronic Resource
    Screening methods of recombination (1984)
    [s.l.] : Nature Publishing Group
    Nature 309 (1984), S. 566-567 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THIS 25-minute videotape is the first of a series of eight* which will deal with the techniques of genetic engineering. Viewed in isolation from the rest of the programmes (which will appear later this year), it gives a foretaste of the high quality of production of the series, but tells us ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/309566b0
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of the extracellular matrix on fibroblast responsiveness to phenytoin using in vitro wound healing models (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 133 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent reports indicate that the topical administration of phenytoin to cutaneous wounds can promote repair. However, isolated skin cells (keratinocytes and flbroblasts) in vitro have varied in their response to phenytoin, giving rise to apparently contradictory results. We have examined how the structure of the extracellular matrix in which human dermal fibroblasts are grown in vitro can influence the response of these cells to phenytoin. The results indicate that, when fibroblasts are embedded within freely-contracting, relaxed, type I collagen matrices, they are insensitive to phenytoin treatment. However, if fibroblasts are grown in collagen matrices which are non-retracting and under tension, phenytoin (5–5μg/ml) significantly (P 〈 0.01) stimulates cell proliferation, and inhibits collagenase activity in a dose- and time-dependent manner. The fact that the effects of phenytoin on dermal fibroblasts are biphasic and influenced by the surrounding matrix may help to explain why in vitro investigations with phenytoin give rise to inconsistent data. It also suggests that the matrix alterations which accompany wound healing may modulate the effects of phenytoin on dermal fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb02620.x
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  • 5
    Electronic Resource
    Electronic Resource
    Investigation of the expression of the extracellular matrix glycoproteins tenascin and fibronectin during acne vulgaris (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Tenascin and fibronectin are extracellular matrix glycoproteins which can interact with cells and alter their capacity to adhere, migrate and proliferate. In contrast with fibronectin, tenascin has a restricted distribution in normal skin, but is induced during epidermal proliferation, and in wound healing. Because acne involves hyperproliferation of ductal keratinocytes, and rupture of the duct may occur during inflammation, the distribution of tenascin and fibronectin was investigated in acne lesions, and also in acne keloids. Biopsies obtained from patients a ending the acne clinics were cryostat-sectioned and stained with tenascin antiserum. The extent of tenascin staining in the dermis around the pilosebaceous unit was measured. Tenascin was continually expressed around normal control pilosebaceous ducts: it was maximal around the acroinfundibulum, extending 20·83±9·32 μm [n= 14) into the dermis, compared with staining around the infrainfundibulum (11·88± 3·70 μm. N = 14). This was not significantly different from staining around normal pilosebaceous ducts obtained from acne patients. In non-inflamed lesions tenascin staining increased significantly around the infrainfundibulum to 76·88±29·97 μm (n= 12), compared with this region in the normal follicles. The staining around the acroinfundibulum did not change significantly. Around inflamed lesions the whole of the dermis was positive for tenascin. No changes were detected in the staining pattern for fibronectin, which stained the whole dermis in all the sections tested. The keloid samples stained strongly for both extracellular matrix glycoproteins. Thus, increased tenascin expression appears to be associated with the development of acne lesions. Tenascin production may be induced by hyperproliferation of ductal keratinocytes and localized loss of control in this process may contribute to the production of acne keloids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb13102.x
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  • 6
    Electronic Resource
    Electronic Resource
    Keratin gene expression during the resolution of psoriatic plaques: effect of dithranol, PUVA, etretinate and hydroxyurea regimens (1989)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 120 (1989), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Quantitative changes in the levels of keratin polypeptides extracted from keratotome shavings from psoriatic epidermis were measured by using one-dimensional SDS-PAGE, followed by scanning densitometry. Values obtained were compared with results for non-lesional epidermis and from epidermis from normal individuals. Patients on four different treatment regimens were investigated by repeated sampling over 3–4 months starting before therapy commenced. The levels of four keratins changed significantly: keratins 1 (70kd) and 2 (66kd) tended to rise to normal levels, while keratins 16 (50 kd) and 18 (44 kd) fell to normal levels. There were differential effects as well as differences in the rates of normalization depending upon the treatment regimen. The most rapid normalization of the levels of all four keratins was observed with topical dithranol (anthralin) treatment (five patients) with plaque resolution and keratin level normalization after 7–9 weeks. Oral hydroxyurea (three patients) had similar effects, but over a longer time scale (20 weeks). In contrast, oral etretinate (four patients) caused a normalization of all except keratin 2 (66 kd) over a period of 20–28 weeks, and keratin 1 (70 kd) levels tended to ‘overshoot' the normal level. PUVA (five patients) caused rapid normalization (in 9–12 weeks) of keratins 2 (66 kd) and 18 (44 kd), but had much weaker effects on keratins 1 (70 kd) and 10 (57 kd). These results suggest that resolution of lesions as judged by clinical criteria can occur without normalization of the keratin electrophoretic profile. Possibly the most reliable marker of clinical resolution was the reduction in keratin 16 (50 kd), since treatment effects on the differentiation of keratins 1 (70 kd) and 2 (66 kd) were different.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1989.tb07760.x
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  • 7
    Electronic Resource
    Electronic Resource
    Pioglitazone-induced myofibroblast cell death: implications for cutaneous scarring (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2003.05501.x
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  • 8
    Electronic Resource
    Electronic Resource
    Selection of a silver staining procedure to detect low quantities of human epidermal 'keratin' protein following electrophoresis in polyacrylamide gels
    Amsterdam : Elsevier
    Clinica Chimica Acta 127 (1983), S. 403-406 
    Details
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0009-8981(83)90168-7
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  • 9
    Electronic Resource
    Electronic Resource
    Planorbis corneus haemoglobin - Circular dichroism and susceptibility to proteases
    Amsterdam : Elsevier
    BBA - Protein Structure 576 (1979), S. 456-465 
    Details
    ISSN: 0005-2795
    Keywords: (Planorbis corneus) ; Circular dichroism ; Hemoglobin ; Protease susceptibility
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0005-2795(79)90420-3
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  • 10
    Electronic Resource
    Electronic Resource
    An electrophoretic and immunologic study of Murex trunculus haemocyanin
    Amsterdam : Elsevier
    Comparative Biochemistry And Physiology 26 (1968), S. 345-351 
    Details
    ISSN: 0010-406X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0010-406X(68)90339-3
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