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  • 1
    Electronic Resource
    Electronic Resource
    Carbon–Carbon Bond Synthesis: The Impact of rDNA Technology on the Production and Use of E. coli Transketolase (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 782 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb40589.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The Impact of Biocatalyst Selection on the Design of Aqueous-Organic Biphasic Biocatalytic Processes (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 613 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb18160.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The use of windows of operation as a bioprocess design tool (1996)
    Springer
    Bioprocess and biosystems engineering 14 (1996), S. 263-268 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Bioprocess design problems are frequently multivariate and complex. However, they may be visualised by a graphical representation of the design constraints and correlations governing both the process and system under consideration, namely windows of operation. Windows of operation exist at all stages of process design and find use both in the identification of key constraints from limited information, and also, with more detailed knowledge, the sensitivity of a process to design or operating changes. In this way windows of operation may be used to help understand and optimise a bioprocess design. In this paper the formulation, development and application of windows of operation is discussed for a range of biological processes including fermentation, protein recovery and biotransformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369924
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The production of Pseudomonas putida for the hydroxylation of toluene to its cis-glycol (1994)
    Springer
    Applied microbiology and biotechnology 41 (1994), S. 495-499 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Pseudomonas putida was grown in a 2.5-l fermentor on a mineral salts medium. Glucose was fed normally over an 18-h period. Gluconate reached about 5 g l-1 in the medium and then fell to zero as it was utilised. The maximum toluene dioxygenase specific activity (2 g g-1 h-1) was obtained over the last 6 h of the fermentation when the pH was fully controlled. In fermentations done at low dissolved O2 tension (DOT) values there was an overall reduction in the cellular enzyme level. When stored at 4°C in phosphate buffer, pH 7.0, harvested bacteria lost half their activity in about 90 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530050179
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  • 5
    Electronic Resource
    Electronic Resource
    The production of Pseudomonas putida for the hydroxylation of toluene to its cis-glycol (1994)
    Springer
    Applied microbiology and biotechnology 41 (1994), S. 495-499 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A constitutive blocked mutant (UV4) of Pseudomonas putida was grown in a 2.5-l fermentor on a mineral salts medium. Glucose was fed normally over an 18-h period. Gluconate reached about 5 gl−1 in the medium and then fell to zero as it was utilised. The maximum toluene dioxygenase specific activity (2 g g−1 h−1) was obtained over the last 6 h of the fermentation when the pH was fully controlled. In fermentations done at low dissolved O2 tension (DOT) values there was an overall reduction in the cellular enzyme level. When stored at 4°C in phosphate buffer, pH 7.0, harvested bacteria lost half their activity in about 90 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00178478
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A structured approach to design and operation of biotransformation processes (1996)
    Springer
    Journal of industrial microbiology and biotechnology 17 (1996), S. 24-29 
    Details
    ISSN: 1476-5535
    Keywords: biotransformation ; aromatic oxidation ; process selection ; Pseudomonas putida
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A structured approach to design and operation of biotransformation (bioconversion) processes, based on previous case studies, has been developed. This requires knowledge of the key characteristics of a biotransformation which determine the constraints on process selection. The approach is illustrated for five biotransformations, two enzymic and three microbial. Some generic problems such as low water solubility and volatility of reactants, reactant and product toxicity have been identified. The microblal oxidations of toluene and fluorobenzene to toluenecis-glycol and fluorocatechol respectively byPseudomonas putida have been used to illustrate how these constraints may be overcome by addition of tetradecane as a second liquid phase, use of a membrane oxygenator and introduction ofin situ product removal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570144
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  • 7
    Electronic Resource
    Electronic Resource
    Choice of microbial host for the naphthalene dioxygenase bioconversion (1996)
    Springer
    Journal of industrial microbiology and biotechnology 16 (1996), S. 274-279 
    Details
    ISSN: 1476-5535
    Keywords: bioconversion ; ethanol ; naphthalene dioxygenase ; co-solvent ; microbial host
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The use of whole cell biotransformations for single and multistep enzyme conversions is gaining widespread application. In this study the naphthalene dioxygenasenah A gene was transferred intoPseudomonas aeruginosa PAC 1R,Escherichia coli JM107 andPseudomonas putida PpG 277. The effect of ethanol on these genetically engineered Gram-negative bacteria was studied by measurement of enzyme activity, stability and cell integrity. Ethanol has been used in biotransformations as a co-substrate carbon source for co-factor recycling and as a co-solvent increasing dissolved substrate and product levels. Ethanol increased the dissolved substrate (naphthalene) concentration slightly and dissolved product ((+)-cis-(1R, 2S)-dihydroxy-1,2-dihydronaphthalene) by approximately 30% at 4% (w/v) ethanol. BothP. aeruginosa PAC 1R andP. putida PpG 277 showed decreased activity with increasing ethanol concentration whilstE. coli enzyme activity increased with increasing ethanol concentration being comparable to that when glucose was used as a carbon source. This project highlighted the many factors involved in the selection of microbial hosts for whole cell biotransformation processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01570034
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  • 8
    Electronic Resource
    Electronic Resource
    The use of windows of operation as a bioprocess design tool (1996)
    Springer
    Bioprocess engineering 14 (1996), S. 263-268 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  Bioprocess design problems are frequently multivariate and complex. However, they may be visualised by a graphical representation of the design constraints and correlations governing both the process and system under consideration, namely windows of operation. Windows of operation exist at all stages of process design and find use both in the identification of key constraints from limited information, and also, with more detailed knowledge, the sensitivity of a process to design or operating changes. In this way windows of operation may be used to help understand and optimise a bioprocess design. In this paper the formulation, development and application of windows of operation is discussed for a range of biological processes including fermentation, protein recovery and biotransformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369924
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Lewis cell studies to determine reactor design data for two-liquid-phase bacterial and enzymic reactions (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 37 (1991), S. 133-140 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Substrate transfer rates from organic to aqueous phases were measured in the presence and absence of biocatalyst in the reaction medium, using modified Lewis cells. These measurements, in combination with intrinsic aqueous phase biocatalytic reaction kinetics, were used to confirm that benzyl acetate hydrolysis by pig liver esterase and toluene oxidation by a strain of Pseudomonas putida occur uniformly throughout the bulk of the aqueous phase. Such data may be used to provide a basis for two-liquid-phase biocatalytic reactor design.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260370207
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