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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical detection of the c-erbB-2 proto-oncogene product in normal, benign and malignant cartilage tissues (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 15 (1989), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Benign and malignant cartilage tumours as well as normal cartilage were stained immunohistochemically with antibodies raised to a synthetic peptide from the sequence of the c-erbB-2 protein. Positive staining was present in 18/23 of the chondrosarcomas and in one case of osteochondroma. Normal and benign neoplastic cartilage tissues revealed negative results. It is concluded that expression of the c-erbB-2 protein may contribute to cell transformation in chondrosarcomas; it is not apparent whether the expression of c-erbB-2 protein in chondrosarcomas characterizes a subpopulation of different prognostic significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1989.tb03042.x
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  • 2
    Electronic Resource
    Electronic Resource
    Correspondence (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 16 (1990), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1990.tb01077.x
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  • 3
    Electronic Resource
    Electronic Resource
    Apoptotic hepatocytes in rejection and vascular occlusion in liver allograft specimens (1998)
    Oxford, U.K. and Cambridge, USA : Blackwell Science Ltd
    Histopathology 32 (1998), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Programmed cell death (apoptosis) has been described in different hepatobiliary diseases and in immune-mediated cytotoxicity. Apoptosis of hepatocytes and bile duct epithelial cells was detected in chronic liver allograft rejection. In severe acute rejection a DNA fragmentation in-situ assay showed positivity of apoptotic cells and centrilobular necrosis. Although apoptosis is triggered by ischaemia, the potential role of apoptosis in tissue damage caused by hepatic vascular occlusion after orthotopic liver transplantation has not yet been investigated.〈section xml:id="abs1-2"〉〈title type="main"〉Methods and resultsWe examined biopsies for apoptotic cell death in 50 liver allografts: 29 with acute liver rejection, six without rejection, five time-zero biopsies, and 10 cases with hepatic artery thrombosis. In addition to a semiquantitative assessment of apoptotic bodies in haematoxylin and eosin stains, an in-situ end nick-labelling technique (TUNEL) was used to detect DNA fragmentation. In all cases with hepatic artery thrombosis the incidence of apoptosis was found significantly increased in comparison to acute rejection.〈section xml:id="abs1-3"〉〈title type="main"〉ConclusionsAs apoptosis is a mechanism in the early stages of tissue damage prior to necrosis, increased apoptosis in liver allograft biopsies might be regarded as a signal of early ischaemia indicating initial vascular occlusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2559.1998.00427.x
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  • 4
    Electronic Resource
    Electronic Resource
    Estrogen receptor status, histologic tumor grade and thymidine labeling index in primary breast carcinoma
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 143 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91512-3
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  • 5
    Electronic Resource
    Electronic Resource
    Translocation (12;13) in a case of infantile fibrosarcoma
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 71 (1993), S. 94-96 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(93)90207-3
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  • 6
    Electronic Resource
    Electronic Resource
    Increased apoptosis of hepatocytes in vascular occlusion after orthotopic liver transplantation (2000)
    Springer
    Transplant international 13 (2000), S. 49-53 
    Details
    ISSN: 1432-2277
    Keywords: Key words Apoptosis of hepatocytes ; Vascular occlusion ; Liver transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Early vascular occlusion is liable to cause graft failure, and differential diagnosis between this condition and primary nonfunction (PNF) caused by preservation injury may be difficult. Apoptosis has been detected in immunomediated cytotoxicity and is known to be triggered by mild ischemia. In a retrospective analysis we investigated the role of apoptosis in vascular occlusion, PNF, and acute allograft rejection to improve the differential diagnosis of early graft failure. The liver graft histology of 75 patients (46 male, 29 female) a median 47 (1–64) years of age was screened semiquantitatively for the rate of apoptosis on the hematoxylin-eosin stain (HE) and by the in situ end nick labeling technique (TUNEL). This cohort included all patients who developed PNF (n = 9) or vascular occlusion (n = 11) after orthotopic liver transplantation (OLT) in the years 1992 to 1996. Within this period of time we performed 205 OLTs on 189 patients. We further included 22 patients with early acute rejection and 11 controls. The highest rates of apoptotic hepatocytes were seen in vascular occlusion (P 〈 0.001). Grafts with PNF were explanted 1–3 days after OLT and showed hepatocytes that were 100 % necrotic. Cases of acute early rejection showed a significantly higher apoptotic cell count than did normal controls (P 〈 0.003), increasing in direct proportion to the severity of rejection. Screening biopsies for the rate of apoptosis can improve the efficacy and accuracy of differential diagnosis of early graft failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050008
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  • 7
    Electronic Resource
    Electronic Resource
    Epithelial markers in synovial sarcoma (1989)
    Springer
    Virchows Archiv 415 (1989), S. 253-258 
    Details
    ISSN: 1432-2307
    Keywords: Epithelial markers ; Synovial sarcoma ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical studies on synovial sarcomas have proved the potentiality of these neoplasm for epithelial and mesenchymal differentiation and antibodies detecting epithelial cells have been found to be helpful in determining the histological types. In this study different epithelial markers directed against various cytokeratins, HMFG-2 and EMA were investigated on paraffin embedded tissues of 13 cases of synovial sarcomas, with regard to their reliability in unmasking the epithelial components demonstrable in this type of neoplasm. The results lead to three conclusions firstly, synovial sarcomas possess the capacity for generating different epithelial cell types with uncommon compositions of intermediate filaments as well as of membrane proteins, secondly, these features may be expressed in a heterogenous pattern even within the same tumour and finally, the use of wide range anti-cytokeratin antibodies covering the spectrum of basic as well as acidic type proteins seems to be necessary for the detection of all epithelial components demonstrable in synovial sarcomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00724912
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of the inflammatory infiltrate in autoimmune cholangitis (1998)
    Springer
    Virchows Archiv 432 (1998), S. 217-222 
    Details
    ISSN: 1432-2307
    Keywords: Key words Cholangitis ; Autoimmune diseases ; T-Lymphocyte subsets ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Autoimmune cholangitis (AIC) is characterised by clinical and/or laboratory features of cholestasis, the presence of antinuclear antibodies and the lack of antimitochondrial antibodies. Histologically, changes largely identical to those found in primary biliary cirrhosis (PBC) are typically found. It is not possible to differentiate between AIC and PBC on conventional morphological grounds, and we therefore wished to find whether there is a difference between these entities in the composition of the inflammatory infiltrate leading to bile duct destruction. In liver biopsies from ten patients with confirmed AIC and ten patients with PBC the inflammatory infiltrate was characterised with antibodies against CD 3, OPD 4 CD 8, GB 7, L 26, CD 56 and CD 57. In AIC, T cells were predominant in the portal inflammatory infiltrate in nine cases. Granzyme B-positive activated cytolytic T lymphocytes were found in the bile duct epithelium in five cases. All these five cases showed inflammatory bile duct destruction. No significant differences between the immunohistochemical findings in AIC and in PBC were found. We suggest that AIC is a subgroup of PBC, antimitochondrial antibody-negative type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050158
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  • 9
    Electronic Resource
    Electronic Resource
    Transferrin receptor (TrfR) expression in breast carcinoma and its possible relationship to prognosis (1986)
    Springer
    Virchows Archiv 410 (1986), S. 69-73 
    Details
    ISSN: 1432-2307
    Keywords: Breast carcinoma ; Transferrin receptor ; Immunohistochemical study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary TrfR, a primitive membrane protein was demonstrated by immunohistochemistry in 87,6% of 105 cases of breast carcinoma, predominantly on the cell surface and in a strong and rather uniform pattern. Sporadic staining in a patchy fashion was observed. No difference between individual tumour types was seen, neither in cytomorphological staining pattern nor in staining intensity. Exceptionally, mucoid carcinomas showed weaker intensity for receptor expression. Because of the heterogenous expression of TrfR within most of the tumours the extent of staining reaction was determined by semiquantitative grading (low, moderate, high). These results were compared with grade of anaplasia, tumour staging and nodal status of the axilla. The extent of immunoreactivity revealed significant correlation with grade of anaplasia, whereas no correlation was found with staging and status of axillary lymph nodes. Tumours with higher degree of malignancy (GII–GIII) showed a higher extent of staining. The presence of TrfR in a high degree of expression thus implies some prognostic value. Its quantitative determination can provide kinetic data on the neoplasm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710908
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