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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 307-311 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malignant transformation of synovial chondromatosis into chondrosarcoma is unusual. Thirteen cases and one series have been reported; only four of them developed in the hip. The overall survival is about 50%, possibly because of the difficulty of arriving at a correct early diagnosis (radiographically and histologically) and subsequent adequate surgical therapy. We report two patients (ages 30 and 50 years) in whom synovial chondrosarcoma developed in previously excised synovial chondromatosis of the hip. The diagnosis was made with modern imaging techniques (computed tomography and magnetic resonance imaging) and verified by open biopsy. The early recognition allowed a wide limb-saving resection; both patients are disease free 3 and 2 years after surgery.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 116 (1997), S. 307-311 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Malignant transformation of synovial chondromatosis into chondrosarcoma is unusual. Thirteen cases and one series have been reported; only four of them developed in the hip. The overall survival is about 50%, possibly because of the difficulty of arriving at a correct early diagnosis (radiographically and histologically) and subsequent adequate surgical therapy. We report two patients (ages 30 and 50 years) in whom synovial chondrosarcoma developed in previously excised synovial chondromatosis of the hip. The diagnosis was made with modern imaging techniques (computed tomography and magnetic resonance imaging) and verified by open biopsy. The early recognition allowed a wide limb-saving resection; both patients are disease free 3 and 2 years after surgery.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0932
    Keywords: Key words Osteoporosis ; Fusion ; Pedicle screw augmentation ; Spine ; Calcium apatite cement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Screw augmentation with calcium apatite cement (CAC) was used in seven patients with a progressive osteoporotic spinal deformity. Thirty-nine spinal segments (64 screws) were augmented: 15 anteriorly (three patients) and 24 posteriorly (five patients). Dorsally, hemilaminectomy was performed at the level of all augmented screws to rule out CAC leakage. Autogenous bone graft was applied in all patients to induce fusion. Screw augmentation failure occurred in only one patient: 1 of the 16 ventral augmented screws (5.5%) was still loose after the augmentation procedure. In three other patients, 4 out of 48 augmented dorsal screws (5.5%) showed CAC leakage at the pedicle corpus vertebra level. Pedicle wall damage was present at two levels, while at two other levels no wall damage was found during visualization. No CAC-related complications were observed perioperatively. No implant migration was observed, and fusion was observed in all cases at follow-up examination performed at a mean of 32 months after surgery.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0932
    Keywords: Key words Vascularized bone graft ; Spinal reconstruction ; Vertebrectomy ; Kyphosis ; Vessel anastomosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In selected spinal deformities the use of a vascularized graft to establish fusion may be considered: compared to a non-vascularized graft it has superior mechanical properties, resulting in greater graft strength and stiffness, and greater effectiveness in facilitating union. Eight patients with a progressive spinal deformity (four cases) and malignancy (four cases) were treated with resection and/or correction and stabilization. To facilitate (multi)level fusion vascularized fibular grafts were used in two cervical and two thoracolumbar deformities. Fibular (two cases) or iliac grafts (two cases) were used in four cases of spinal reconstruction after vertebrectomy for malignancy. In all patients complete incorporation of the graft was obtained within 5 weeks to 8 months postoperatively. Complications occurred in three cases: one patient had a transient laryngeal edema and laryngeal nerve palsy. Another patient had a non-fatal deep vein thrombosis with pulmonary embolisms, successfully treated with anticoagulants. A third patient developed a lung infection and subsequently a deep infection around the dorsal instrumentation; after hardware removal the infection was controlled. At the latest follow-up (mean 30 months, range 24– 48 months) six out of eight patients are alive. One patient died 2.5 years after the intervention due to widespread metastases, while another patient died in the postoperative period due to unknown reasons. Vascularized bone graft in spinal surgery facilitates primary mechanical stability and rapid fusion, and it has higher resistance to infection. The variety of applications of a vascularized graft may extend the range of indications for the use of grafts in spinal surgery.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0932
    Keywords: Key words Sagittal balance ; Sagittal vertical axis ; Spinal ; deformities ; Model ; Human posture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sagittal balance of the spine is becoming an important issue in the assessment of the degree of spinal deformity. On a standing lateral full-length radiograph of the spine, the plumb line, or sagittal vertical axis (SVA), can be used to determine the spinal sagittal balance. In this procedure patients have to adopt a habitual standing position with the knees extended during radiographic examination, though it is not known whether small changes in the position of the lower extremities affects the location of the SVA. The purpose of the present study was to investigate the effect of postural change on shifts of the SVA, and to evaluate whether the SVA as measured on a standing full-length lateral radiograph can be used as an accurate measurement of spinal balance in clinical practice. Sagittal balance was analyzed using a patient with ankylosis of the entire spine due to ankylosing spondylitis, to eliminate segmental movement of the spine. A virtual SVA was constructed for seven different standing postures by cross-referring the coordinate systems from a standing full-length lateral radiograph of the spine with video analysis. The horizontal distance between the SVA and the anterior superior corner of the sacrum was measured for each posture. Small changes in the joint angles of the lower extremities affected the SVA significantly, and resulted in the horizontal distance between the SVA and the anterior superior corner of the sacrum varying from –4.5 to +14.9 cm. High correlations were found between this distance and the joint angle of the hip (r = –0.959), knee (r = –0.936), and ankle (r = 0.755) (P 〈 0.01). The results of the study showed that SVA translations during standing radiographic analysis in a patient with a fixed spine depend on small changes in the hip, knee, and ankle joints. Thus, sagittal spinal (im)balance in ankylosing spondylitis can not be measured from the SVA on a standing lateral full-length radiograph of the spine unless strict procedures are developed to control for the angle of the hip, knee, and ankle joints. The accuracy of the SVA as a measurement of sagittal spinal balance in other spinal deformities, with possible additional segmental movements, therefore remains questionable.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Surgical endoscopy and other interventional techniques 14 (2000), S. 849 -852 
    ISSN: 1432-2218
    Keywords: Key words: Thoracoscopy — Spondylectomy — Thoracic spinal tumors — En bloc resection — Spine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We describe a combined surgical technique for tumors of the thoracic spine consisting of a thoracoscopically assisted ventral release followed by a dorsal en bloc spondylectomy and reconstruction. The technique enables thoracoscopic access and release of the involved spinal segment(s) to achieve surgical and histopathologic wide margins, avoiding the disadvantages inherent to thoracotomy. Two patients were successfully treated with solitary tumors involving T10 and T7–8 vertebra. The resection margins were free of tumor. Thoracoscopically assisted total en bloc spondylectomy allows wide excision of thoracic spinal tumors with free resection margins in selected patients; the operation can be performed under direct vision without contamination of uninvolved parts.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0021-9304
    Keywords: cartilage ; growth factors ; tissue engineering ; osteogenic protein-1 ; cartilage repair ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The objective of this study was to examine in vitro the influence of recombinant human osteogenic protein-1 [rhOP-1, or bone morphogenetic protein-7 (BMP-7)] on cartilage formation by human and goat perichondrium tissue containing progenitor cells with chondrogenic potential. Fragments of outer ear perichondrium tissue were embedded in clotting autologous blood to which rhOP-1 had been added or not added (controls), and the resulting explant was cultured for 3 weeks without further addition of rhOP-1. Cartilage formation was monitored biochemically by measuring [35S]-sulphate incorporation into proteoglycans and histologically by monitoring the presence of metachromatic matrix with cells in nests. The presence of rhOP-1 in the explant at the beginning of culture stimulated [35S]-sulphate incorporation into proteoglycans in a dose-dependent manner after 3 weeks of culture. Maximal stimulation was reached at 40 μg/mL (human explants: +148%; goat explants: +116%). Histology revealed that explants treated with 20-200 μg/mL of rhOP-1, but not untreated control explants, contained areas of metachromatic-staining matrix with chondrocytes in cell nests. It was concluded that rhOP-1 stimulates differentiation of cartilage from perichondrium tissue. The direct actions of rhOP-1 on perichondrium cells in the stimulation of chondrocytic differentiation and production of cartilage matrix in vitro provides a cellular mechanism for the induction of cartilage formation by rhOP-1 in vivo. Thus rhOP-1 may promote early steps in the cascade of events leading to cartilage formation and could prove to be an interesting factor in the regeneration of cartilage in articular cartilage defects. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 40, 614-620, 1998.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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