ISSN:
0025-116X
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Physics
Notes:
Copolymers of N-substituted methacrylamide (1a, b), new biomaterials, were synthesized to be used as encapsulating membranes of carbon kidney. In order to obtain a copolymer with a suitable hydrophilic property, the aminolysis of styrene-methyl methacrylate (St-MMA) copolymer with N-(2-hydroxyethyl)ethylenediamine was carried out under various conditions. The occurrence of aminolysis was confirmed by elemental analysis, IR and 1H NMR spectra. It was shown that a copolymer of N-substituted methacrylamide with a predictable degree of hydrophilicity can be obtained by controlling the composition ratio of the St-MMA copolymer and the degree of aminolysis of the copolymer. Hemoperfusion experiments with a living animal (dog), using a minicolumn with several types of microspheric activated carbon encapsulated with various copolymers, showed that copolymers with suitable hydrophilicity and hydrophobicity or with proper structure have a good blood compatibility. Studies with creatinine, uric acid and vitamin B12 showed that microspheric activated carbon, encapsulated with N-substituted methacrylamide copolymers of proper hydrophilicity and structure, has a good penetration property, and that detaching of activated carbon particles is effectively prevented.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/macp.1985.021861206
Permalink
