ISSN:
1432-1076
Keywords:
Key words Double negative
;
T-lymphocytes
;
T-cell receptors
;
Severely handicapped
;
IgG level
;
Infectious diseases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract CD3+4–8– double negative cells in peripheral blood lymphocytes were examined in 21 severely handicapped children divided into two groups according to serum IgG level. All children were bedridden and were taking multiple anticonvulsants and there were no apparent clinical differences between these two groups. Serum levels of IgG correlated well with percentages of CD3+4–8– double negative lymphocytes in patients of both groups. In comparisons between the two groups, the high IgG group had higher counts of CD3+4–8– double negative lymphocytes in peripheral blood than the normal IgG group. Two distinct types of double negative cells were identified in the patients with high IgG: one had T-cell antigen receptors of γd heterodimers, the other had receptors of αb chains on their surface. As double negative T-cells are reported to have an important role in defence against bacterial infections, the increased numbers of CD3+4–8– T-cells of both phenotypes in the high IgG patients may reflect exposure to repetitive bacterial stimuli or persistent subclinical infection which in many cases, may be undetectable clinically. Moreover, the hyperimmune states shown by the high serum IgG of these patients may result from the appearance of these unique lymphocytes because they are reported to have a helper function for IgG synthesis in vitro. Taken together, the increased numbers of double negative cells in patients with high IgG may reflect activated defence mechanisms and the development of hyperimmune status.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954738
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