ISSN:
1573-904X
Keywords:
lipid emulsion
;
flocculation
;
coalescence
;
DLVO theory
;
phosphatidylcholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Purpose. The stability of lipid emulsions (LE) containing various cosurfactants (oleic acid, cholesterol, Tween 80, or HCO-60) was evaluated using the maximum total interaction energy, Vt max, and the energy barrier for coalescence, W. Methods. The Vt max and W were calculated from the ζ potential and the rate of increase in LE particle size, respectively. Results. The Vt max and W of LE containing the oleic acid were 0.598 × 10−19 J and 3.03 × 10−19 J, respectively, while those of LE without the cosurfactant were 0.141 × 10−19 J and 1.36 × 10−19 J. Conclusions. These findings suggest that oleic acid prevents the flocculation and coalescence of LE. The Vt max and W of LE containing the cholesterol were 0.435 × 10−19 J and 0.63 × 10−19 J, respectively, suggesting that the cholesterol prevents the flocculation of LE but does not affect the coalescence. Analysis of the stability of LE was performed by the separate considerations of the flocculation and coalescence.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1016205203264
Permalink
