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  • 1
    Electronic Resource
    Electronic Resource
    High ethylmercury in river fish by man-made pollution (1975)
    Springer
    Bulletin of environmental contamination and toxicology 14 (1975), S. 409-414 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01705505
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A simple method for screening assessment of acute toxicity of chemicals (1990)
    Springer
    Archives of toxicology 64 (1990), S. 262-268 
    Details
    ISSN: 1432-0738
    Keywords: Acute toxicity ; Approximate LD50 ; Screening assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We proposed a simple method for screening assessment of acute oral and dermal toxicity using only three rats and mice of each sex at each dose level. Animals were first treated with chemicals at a dose of 2000 mg/kg and were carefully observed for compound-related morbidity and mortality. If none of the animals died, the following toxicity tests were suspended. If some of the animals died, toxicity tests at doses of 200 and 20 mg/kg were performed. The approximate LD50 values calculated by this method showed little difference between two separate laboratories and were in good agreement with LD50 values reported in the literature. Our toxicological data also showed that LD50 values were about 2–2.5 times the MNLD (maximum non lethal dose) in acute oral and dermal toxicity. This meant that a chemical could be regarded as having an LD50 of about 4000 mg/kg or higher when there was no mortality at the dose of 2000 mg/kg. A chemical with such low toxicity would not require further testing for lethal effects. Therefore, this simple method combining the fixed-dose procedure with the limit test is suitable for determination of approximate LD50 values of chemicals and for screening for necessity for classical full LD50 test using many animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972985
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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