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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International orthopaedics 9 (1985), S. 19-27 
    ISSN: 1432-5195
    Keywords: Cervical spine ; Soft disc hernia ; Discography ; Radicular pain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La définition de la hernie discale cervicale n'est pas toujours claire, aussi avons-nous étudié 34 malades chez qui les éléments discaux avaient été expulsé ou avaient migré en dehors de l'espace intervertébral. Il y avait 22 cas de type central ou paracentral et 12 cas de type postéro-latéral. Le diagnostic a été obtenu grâce à la discographie, en utilisant des clichés de face, de profil, ainsi que deux clichés obliques. Tous les malades se plaignaient de douleurs ou de gêne au niveau du cou ou de la région inter-scapulaire, exagérées par le test de compression du cou et retrouvées lors de la discographie. Les douleurs étaient importantes dans tous les cas de type postéro-latéral et dans la moitié environ de ceux de type central ou paracentral. Il existait des signes médullaires, tels qu'une augmentation des réflexes au niveau des membres inférieurs, dans 15 hernies centrales ou paracentrales et dans 5 hernies postéro-latérales. Ces signes étaient proportionnels à la largeur du canal rachidien et au volume de la hernie. La discographie et la reproduction des douleurs sont les principaux éléments du diagnostic de ce type de hernies. Il est maintenant possible de distinguer les variétés centrales et paracentrales grâce à l'utilisation du scanner après discographie. 12 malades ont bénéficié d'un traitement conservateur et 22 ont été opérés; de bons résultats ont été obtenus dans les deux groupes.
    Notes: Summary The definition of soft disc hernia of the cervical spine is not always clear, so we have studied 34 cases where soft disc material was extruded or had migrated outside the intervertebral space. There were 22 cases of the paracentral-central type and 12 cases of the posterolateral type. The diagnosis was made by discography using anteroposterior, lateral and both oblique radiographs. All the patients complained of pain or discomfort in the neck or the interscapular region which was increased by the neck compression test and reproduced during discography. Severe pain in the area was present in all the cases of the posterolateral type and in about half of the paracentral-central type. Cord signs, such as increased reflexes in the lower limbs, were found in 15 cases of the paracentral-central type and in 5 cases of the posterolateral type. These signs correlated with the width of the spinal canal and the amount of prolapsed disc material. Discography and reproduction of pain were most useful for the diagnosis of this type of hernia. It has now become possible to differentiate the paracentral type from the central type by performing computerised tomography scanning after discography. We treated 12 cases conservatively and 22 cases surgically, and obtained good results in both groups.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 99 (1981), S. 97-103 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the nerve, especially motor nerve, regeneration after interfascicular grafting, the method most often used clinically, the nerve grafting was performed on 40 adult rabbits. By resecting 2.0 cm of the right peroneal nerve, the sural nerve was made into 4 interfascicular grafts under a operating microscope. The cross section area of the grafts was about the same as that of peroneal nerve. Histological and evoked electromyographic observations were conducted on the maturation of regenerating nerves of up to 24 post-operative months, when the maturation would have been completed. The present histological and evoked electromyographic observations revealed that about 70% of nerve, especially motor nerve, recovery was attained after interfascicular grafts as compared with normal nerve. In the nerve regeneration after interfascicular grafts, several factors differing from the case of suture are involved, and these factors were considered from the experimental findings.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 96 (1980), S. 271-277 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The so-called soft disc herniation (the extruded or sequestered type) of cervical spine is relatively rare. For such a diagnosis precise neurological examination, myelography and discography are employed, but among them the specific reproduction of the patient's symptoms and the radiographic appearance of the disc by discography are especially important. Our 8 cases of soft disc herniation have been classified into central-paracentral and posterolateral types by the direction of extruded material from discographic pictures. Every type shows the complications of root pain. Discussion relates to the pain that accompanies this soft disc herniation. In half of the cases extruded disc material has been removed but others have been improved by conservative treatment.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 7-10 
    ISSN: 1435-5604
    Keywords: Key words: proteoglycan ; joint capsule ; differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The proliferation and differentiation of cells are greatly influenced by their environment. Many growth factors and cytokines are reported to be environmental factors that affect the proliferation and differentiation of cells. Mechanical stress is also considered to influence these physiological reactions. The joint capsule, which is a part of the joint tissue, plays a very important role in the stability of the joint and in maintaining the intracapsular phenomenon. In patients with dislocated hip arthropathy, this capsule is involved in the weightbearing function by forming a sliding surface between the capsule and the femoral head articular cartilage. The surface of the tissue macroscopically shows cartilaginous change, which indicates cartilaginous differentiation caused by mechanical stress. We examined the cartilage-specific proteoglycan component, which is composed of cartilaginou matrix at the differentiation site. We investigated proteoglycan production, molecular size, and the gene expression of cartilaginous substrate. At the inner layer of the weightbearing area of the joint capsule, proteoglycan production was significantly higher than that of other noncartilaginous tissue. We also identified the gene expression of cartilaginous proteoglycan using the reverse transcription polymerase chain reaction (RT-PCR) method.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-5604
    Keywords: rheumatoid arthritis ; cartilage ; human chondrocyte ; established cell line ; autoimmunity/autoantibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An immortal human chondrocytic cell line (HCS-2/8) derived from a chondrosarcoma was used as a source of human antigens to find humoral antibodies to cell surface proteins of human chondrocytes in sera from patients with rheumatoid arthritis (RA). Membrane fractions prepared from the cell line were subjected to Western blot analysis using RA and normal sera as probes. RA sera recognized about a dozen bands, but three of these bands, with molecular weights of 105 kDa, 65 kDa, and 47 kDa, were found to be specific for the RA sera (P〈0.05). These bands disappeared following V8 protease digestion, indicating that they were proteins. Among patients with 4 years or more of RA disease activity, reactivity against 105-kDa and 68-kDa proteins was relatively high in those whose joints showed a high degree of erosion. We suspect that levels of these two antibodies are suggestive of changes associated with the natural course of RA.
    Type of Medium: Electronic Resource
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