Electronic Resource
s.l. ; Stafa-Zurich, Switzerland
Solid state phenomena
Vol. 121-123 (Mar. 2007), p. 747-750
ISSN:
1662-9779
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Physics
Notes:
Amino-modified tetrapod-like ZnO nanostructures were tried as novel carriers formammalian cell transfections. The nanostructures consisted of four needle-shaped tetrahedrallyarranged legs connected at the center. After silica coating and amino modification, ZnOnanostructures complexes bound plasmid DNA through electrostatic interactions in aqueous solution.When mixed with cells, DNA-nanostructures attached easily onto cell membranes and entered thecells for gene expressions. Due to high positive charge densities on surfaces and needle-shapedtetrahedral structures, functionalized ZnO used as carriers for cell transfections with both hightransfection efficiency and little cytotoxicity. And a possible transfection machamism was proposedin this report
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/23/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.121-123.747.pdf
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