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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of anesthesia 3 (1989), S. 194-199 
    ISSN: 1438-8359
    Keywords: Alveolar hypoxia ; Hypoxic pulmonary vasoconstriction ; Shunting ; Microcirculation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using open chested dogs (n = 12), we tested the hypothesis that the pulmonary capillary changes its caliber in response to alveolar hypoxia. Animals were placed in a left upright lateral position. Pulmonary perfusion was measured by electromagnetic flow transducers attached to the main and left pulmonary arteries. Systemic artery, pulmonary artery and pulmonary vein pressures were measured via catheters inserted into them. Shunt flow through the pulmonary capillary beds was evaluated by the microsphere method, injecting a mixture of three different size (3,9 and 15 µm) redioactive microspheres into the inferior vena cava. Right one lung ventilation with left lung atelectasis or left lung insufflation of 5 cmH2O (O2 or He) was achieved by occluding the left main bronchus with a blocker attached to an endotracheal tube. Right one lung ventilation caused redistribution of the perfusion from the left lung to the right lung. Left pulmonary vascular resistance increased significantly, while total pulmonary vascular resistance showed no significant changes. The shunt ratios of the 3 and 9 µm microspheres were not changed by right one lung ventilations with left lung atelectasis or insufflation. The shunt ratio of the 3 µm microspheres through the left lung was significantly higher than that through two lungs during both the two lung and one lung ventilations. We concluded that caliber changes in the pulmonary capillary do not occur in response to alveolar hypoxia. (Fujita Y, Yano H, Takaori M: Effects of alveolar hypoxia on pulmonary capillary beds. J Anesth 3: 194–199, 1989)
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1438-8359
    Keywords: Airway resistance ; Measurement ; General anesthesia ; airflow ; Lung volume
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of lung volume and respiratory airflow on airway resistance were studied in five anesthetized and paralyzed patients. Airway resistance measured during the inspiratory phase with intermittent constant airflow inflatoins decreased in inverse correlationship to increases in lung volume. Airway resistance measured during the expiratory phase with an airway interruption technique, on the other hand, increased with a linear relationship to the expiratory airflow as expressed by a function of Y = K1 + K2X. K1, calculated from the values of airway resistance corresponding to three different airflows, was unaffected by intentional expiratory resistance loading. Thus, simultaneously with the measurement of airway resistance by this method, expiratory gas sampling with a Douglas bag can be done if necessary. Since the K2 value of the endotracheal tube used in this study (Portex® I.D. 8 mm, length 26 cm) was quite high (5.0 cmH2O·1−2·sec2), depending on the airflow, the presence of the endotracheal tube strongly affected the measurement of airway resistance during general anesthesia. K1 measured by the above method, however, may be considered as the best way to evaluate the lower airway resistance independent of either lung volume or expiratory airflow. (Sakai T, Yoshida H, Yano H et al.: Measurement of airway resistance in anesthetized and paralyzed subjects: proposal for evaluation of K1 values. J Anesth 2: 139–145, 1988)
    Type of Medium: Electronic Resource
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