ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
The purpose of this study was to explore the feasibility of repairing massive bone defectwith in vivo tissue engineering(TE) bone, and to provide experimental evidence for the applicationof in vivo TE bone into clinic in the future. Six calcium phosphate ceramics (Ca-P ceramics)columns were prepared, and then immersed in dynamic revised simulated body fluid (RSBF). 72hours later, the bone-like apatite was formed on the surface and pore walls of ceramics. Three dogswere used in this study. Two ceramic columns were implanted bilaterally in the femoral muscles ofeach dog to construct living bone graft of in vivo TE bone. 6 weeks after implantation, they weretransplanted to the box-like bone defects sites created in bilateral mandible of the same animals.The dogs were sacrificed at 8, 12 week after operation respectively. Samples were harvested forgross observation, X-ray examination, tetracycline fluorescence labeling, SPECT and histologicalobservation. These results demonstrated that as a living bone graft, in vivo TE bone participated inthe bone metabolism of host, and integrated with the host bone. It is feasible to reconstruct box-likebone defect of mandible with the in vivo TE bone
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/53/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.330-332.1165.pdf
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