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  • 1
    Electronic Resource
    Electronic Resource
    Myocardial accumulation and clearance of technetium 99m Teboroxime at 100%, 75%, 50% and zero coronary blood flow in dogs (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 725-731 
    Details
    ISSN: 1619-7089
    Keywords: Teboroxime ; Myocardial perfusion ; Techneticum ; Radionuclide imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sequential changes in the regional distribution of technetium 99m Teboroxime (SQ30217) were evaluated in nine dogs with graded coronary artery stenosis, occlusion and reperfusion of either the left anterior descending or left circumflex arteries.99mTc-Teboroxime accumulation recorded by planar imaging was compared with directly measured coronary blood flow (Doppler) and regional myocardial perfusion (microspheres). Serial images were recorded beginning at the time of injection and continuing for the next 18 min. The data were summed from minutes 2–3, 3–6, 4–8 and 9–18 after injection for comparison with the other parameters. Myocardial clearance of Teboroxime was analysed at each level of blood flow. There was a linear relationship between the Teboroxime activity ratio (abnormal/normal) and coronary blood flow (r=0.96) and regional myocardial perfusion (r = 0.99). Zones of diminished perfusion were least apparent in the summed images recorded during minutes 2–3. In later images, the lesions were well visualized. The myocardial clearance half-times at 100%, 75% and 50% flow were not significantly different, while clearance half-time at total occlusion was significantly (P 〈 0.01) faster. In the 3–6, 4–8 and 9–18 minutes summed images, the Teboroxime activity ratio increased significantly (P 〈 0.01) after reperfusion compared with total occlusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00956713
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of single photon wall motion and perfusion studies in the evaluation of patients with suspected coronary artery disease (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 269-278 
    Details
    ISSN: 1619-7089
    Keywords: Coronary artery disease ; Myocardial ischaemia ; Myocardial perfusion imaging ; Ventricular function ; Ejection fraction ; Blood pool imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cardiovascular nuclear medicine procedures are useful to characterize coronary artery disease by measuring changes in perfusion, myocardial metabolism, cellular integrity, and regional or global function. Coronary angiography, while an excellent indicator of anatomic changes in arterial lumenal diameter, is a poor predictor of downstream perfusion, since neither the length of the stenosis nor absolute lumenal diameter is considered. Even if the anatomy is known, perfusion measurements provide information about ischaemia and ventricular dysfunction that is helpful for planning therapy. New technetium 99m-labelled perfusion agents are likely to improve the certainty of diagnosis due to their higher photon flux. The development of techniques for continuous ventricular function monitoring during daily activities provides an opportunity for detecting the impact of silent ischaemia on cardiac function. The role of the radionuclide imaging procedures in classifying patients with coronary disease is discussed in light of the pathophysiology of ischaemia and necrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00812369
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Myocardial accumulation and clearance of technetium 99m Teboroxime at 100%, 75%, 50% and zero coronary blood flow in dogs (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 725-731 
    Details
    ISSN: 1619-7089
    Keywords: Teboroxime ; Myocardial perfusion ; Techneticum ; Radionuclide imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sequential changes in the regional distribution of technetium 99m Teboroxime (SQ30217) were evaluated in nine dogs with graded coronary artery stenosis, occlusion and reperfusion of either the left anterior descending or left circumflex arteries. 99mTc-Teboroxime accumulation recorded by planar imaging was compared with directly measured coronary blood flow (Doppler) and regional myocardial perfusion (microspheres). Serial images were recorded beginning at the time of injection and continuing for the next 18 min. The data were summed from minutes 2–3, 3–6, 4–8 and 9–18 after injection for comparison with the other parameters. Myocardial clearance of Teboroxime was analysed at each level of blood flow. There was a linear relationship between the Teboroxime activity ratio (abnormal/normal) and coronary blood flow (r=0.96) and regional myocardial perfusion (r = 0.99). Zones of diminished perfusion were least apparent in the summed images recorded during minutes 2–3. In later images, the lesions were well visualized. The myocardial clearance half-times at 100%, 75% and 50% flow were not significantly different, while clearance half-time at total occlusion was significantly (P 〈 0.01) faster. In the 3–6, 4–8 and 9–18 minutes summed images, the Teboroxime activity ratio increased significantly (P 〈 0.01) after reperfusion compared with total occlusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173431
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Accumulation of immunoglobulin G at focal sites of inflammation (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 159-165 
    Details
    ISSN: 1619-7089
    Keywords: Infection ; Immunoglobulin ; IgG ; Rate constants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the factors responsible for the accumulation indium-111 immunoglobulin Gr (111InIgG) at sites of inflammation, sequential measurements of tissue blood volume, interstitial fluid volume and accumulation of radiolabelled albumin and IgG were made in rats following Escherichia coli infection in the thigh. Compared with normal thigh muscle, there was ∼two-fold increase in interstitial fluid volume and ∼ 1.5-fold increase in plasma and red blood cell volumes in infected muscle. For both proteins, there was a fivefold increase in influx rate constant (kin) in infected muscle. In normal muscle, the interstitial fluid concentration of labelled human serum albumin (111In-HSA) was significantly higher than that of 111In-IgG (P〈0.01). In contrast, the concentrations in infected muscle were nearly identical. The concentration ratios (infected to normal muscle) were 1.7:1 for HSA and 3:1 for IgG. These data suggest that the infection imaging properties of 111In-IgG are related to expansion of the space available to macromolecules in infected tissue and increased transport into this space. At clinically important imaging times (24–48 h after injection), the higher target-to-background ratio of 111In-IgG compared with 111In-HSA is not due to the higher accumulation IgG in infected tissue but rather to the higher accumulation of HSA in normal tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173275
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Uridine: A marker of myocardial viability after coronary occlusion and reperfusion (1993)
    Springer
    The international journal of cardiovascular imaging 9 (1993), S. 273-280 
    Details
    ISSN: 1573-0743
    Keywords: uridine ; deoxyglucose ; RNA ; viability ; myocardial ischemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tissue accumulation of radiolabeled uridine, a precursor of uracil, reflects ribonucleic acid (RNA) synthesis and may be a marker of viability. To test this hypothesis, myocardial accumulation of H-3 uridine was compared to deoxyglucose uptake and histopathology in an experimental model of myocardial ischemia. In 18 Wistar rats the left coronary artery was occluded for 5, 10 or 60 minutes followed by reperfusion. Five hours later H-3 uridine and C-14 deoxyglucose were administered intravenously and the animals were sacrificed 45 minutes later. The left ventricle of each animal was divided into 12 segments and myocardial tracer accumulation was determined by measurement of tissue radioactivity. From the results of TTC staining, the animals were divided into 3 groups: Group I — ischemia without infarction (n=9); Group II — non-transmural infarction (n=4) and transmural infarction (n=5). Retention of uridine was observed in ischemic zones with enhanced deoxyglucose accumulation in Group I animals. Uridine accumulation was relatively preserved compared to slightly decreased deoxyglucose accumulation in regions of non-transmural infarction in Group II. In Group III, uridine accumulation decreased in parallel with deoxyglucose in zones of infarction. These results suggest that accumulation of radiolabeled uridine may be a useful indicator of viability in ischemic myocardium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01137154
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    Paper (German National Licenses)
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