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  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF PYRIDOXINE DEFICIENCY IN NERVOUS TISSUE MAINTAINED IN VITRO (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 166 (1969), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1969.tb54265.x
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructural analysis of membrane-bound polysomes in human myeloma cells (1982)
    Springer
    Annals of hematology 44 (1982), S. 51-63 
    Details
    ISSN: 1432-0584
    Keywords: Myeloma cell ; Immunoglobulin ; Membrane-bound polysome ; Ultrastructural analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We prepared ultra-thin sections of human myeloma cells, in which the rER was cut tangentially, and studied the make-up and distribution of membrane-bound polysomes electronmicroscopically. In IgG myeloma large and small polysomes were detected. The polysome distribution curve showed a high peak at 7 ribosomes and a lower peak at 17–18 ribosomes. IgA-, IgD- and IgE myeloma, as well as macroglobulinemia, showed peaks at 7 and 13 ribosomes. BJP myeloma manifested a sharp peak only at 7 ribosomes. Our results suggest that BJP myeloma has only small polysomes participating in L-chain synthesis, while the other myelomas exhibited large and small polysomes participating in H- and L-chain synthesis, respectively. The quantitative ratio of small and large polysomes was determined on the basis of an analytically corrected direct count.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320686
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  • 3
    Electronic Resource
    Electronic Resource
    A human B lymphocyte antigen (P-76) shared by B-cell chronic lymphocytic leukemia cells and hairy cell leukemia cells (1983)
    Springer
    Annals of hematology 46 (1983), S. 249-259 
    Details
    ISSN: 1432-0584
    Keywords: B-lymphocyte ; Chronic lymphocytic leukemia ; Hairy cell leukemia ; Antiserum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A membrane antigen with an apparent specificity to B lymphocytes was detected with immunochemical techniques and its properties were analyzed. Anti-B-CLL serum was raised in a rabbit by immunization with B-cell chronic lymphocytic leukemia (B-CLL) cells. This anti-B-CLL serum was absorbed with erythrocytes, liver homogenate and insolubilized immunoglobulins. After further absorption with T-CLL cells, chronic myelocytic leukemia (CML) cells and acute myelocytic leukemia (AML) cells, the anti-B-CLL serum still reacted with peripheral blood B lymphocytes, B-CLL cells and hairy cell leukemia (HCL) cells. In contrast, no reactivity was seen with peripheral blood T lymphocyte or monocytes, or leukemia cells of non-B cell origin. An immunoprecipitation of radiolabeled cell surface proteins was attempted using the anti-B-CLL serum in the presence of Staphylococcus Aureus Cowan 1 (SaCl), and the precipitates were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). A membrane antigen with an apparent molecular weight of 76,000 daltons (P-76) was immunoprecipitated with the anti-B-CLL serum from the lysates of normal B lymphocyte, B-CLL cells and HCL cells. The antigen (P-76) is not composed of disulfide-linked subunits and has no structural relationship with HLA-DR (Ia-like) antigens or other known antigens. These results suggest that this antigen is B-lymphocyte specific, and favour the B-lymphocyte nature of HCL cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319865
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural analysis of membrane-bound polysomes in mouse “nonsecretory” myeloma (nonproducing type) (1983)
    Springer
    Annals of hematology 47 (1983), S. 147-152 
    Details
    ISSN: 1432-0584
    Keywords: Mouse myeloma ; Immunoglobulin ; Membrane-bound polysome ; Ultrastructural analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using our electron microscopic method of polysome analysis we ascertained the numbers of membrane-bound polysomes and their constituent ribosomes in myeloma cells of J 606 (IgG3) and MOPC315 (IgA) parent cell lines and in their variants that did not produce and, accordingly, secrete either H- or L-chains. Both variants had far fewer membrane-bound polysomes than the respective parent lines. The polysome distribution curve drawn for each of these variants showed one peak at 5 – 6 ribosomes. In contrast to this finding, the distribution curves for the J 606 and MOPC315 parent lines gave two peaks. These observations on mouse myelomas strongly resembled those on human myelomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320176
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  • 5
    Electronic Resource
    Electronic Resource
    Heavy chain loss after treatment with melphalan in a patient with “nonsecretory” myeloma (1983)
    Springer
    Annals of hematology 46 (1983), S. 73-80 
    Details
    ISSN: 1432-0584
    Keywords: Multiple myeloma-Plasma cell ; Electron microscopy ; Fluorescent antibody technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of “nonsecretory” myeloma is described. The patient had typical osteolytic lesions and marked infiltration of myeloma cells in the bone marrow, and plasma cell leukemia. A good partial remission was obtained with Melphalan, but the patient relapsed and died one year later. Immunofluorescent and immunoelectroscopic studies on the myeloma cells demonstrated the presence of cytoplasmic γ-and κ-chains at the initial stage and of only κ-chains at a relapse. The electron microscopic method for polysome analysis indicated that both L-and H-chains were synthesized on membrane-bound polysomes initially, but the ability to produce H-chain was missing at the relapse.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320661
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  • 6
    Electronic Resource
    Electronic Resource
    Immunoglobulin production and secretion in bence jones protein myeloma and “nonsecretory” myeloma (1982)
    Springer
    Annals of hematology 45 (1982), S. 121-129 
    Details
    ISSN: 1432-0584
    Keywords: Multiple myeloma ; Immunoglobulin ; Electron microscopy ; Fluorescent antibody technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using our electron microscopic method for polysome analysis and an immunofluorescent technique we studied Ig production and secretion by tumor cells in seven BJP myeloma patients and seven “nonsecretory” myeloma patients. In BJP myeloma Ig production and secretion is of three types: Type 1, only L-chains are synthesized and secreted; Type 2, the myeloma cells show fluorescence for H-chains, but upon polysome analysis there is no peak at polysomes corresponding to H-chain production; Type 3, the myeloma cells show fluorescence for H-chains, and polysome analysis shows two peaks corresponding to L- and H-chain production. Polysome analysis of “nonsecretory” myelomas show the presence of only very few membrane-bound polysomes and their distribution curves are entirely different from those of “ordinary” myeloma. Furthermore, the distribution patterns vary among seven cases. Results obtained by polysome analysis and immunofluorescent technique suggest that the “nonsecretory” myeloma could be divided into several subtypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319940
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  • 7
    Electronic Resource
    Electronic Resource
    Congenital dyserythropoietic anemia type I: A freeze-fracture and thin section electron microscopic study (1983)
    Springer
    Annals of hematology 46 (1983), S. 329-338 
    Details
    ISSN: 1432-0584
    Keywords: Dyserythropoietic anemia ; Freeze-fracture ; Erythroblast ; Nuclear pore
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Congenital dyserythropoietic anemia type I was diagnosed in a Japanese patient. Electron microscopic examination of thin sections revealed the features of erythroblasts peculiar to CDA type I; namely “spongy appearance” of nucleus and “internuclear chromatin bridge” etc. However, the widening of nuclear pores, which has been reported as another peculiar feature of CDA type I erythroblasts, were not confirmed. Aberrations of erythroblast nuclear membrane which have not been hitherto noticed were as follows: The nuclear evelopes of erythroblasts frequently lacked heterochromatin application in wide areas where they often showed a marked invagination or evagination. This is associated with the invasion of cytoplasmic organelles into the nuclear territory and occasionally with the extrusion of the nucleolus into the cytoplasm. There were no nuclear pores on the invaginated or the evaginated portions of the nuclear envelope where the perinuclear cistern was compressed to lose the cisternal space, or widened to contain some membrane debris. The findings with thin sectionings were confirmed with freeze-fracturing. Both findings suggest that an aberration may reside in the erythroblast nuclear membrane itself, but not in nuclear pores.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320693
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  • 8
    Electronic Resource
    Electronic Resource
    A phase II study of mitoxantrone in acute leukemia (1985)
    Springer
    Investigational new drugs 3 (1985), S. 197-201 
    Details
    ISSN: 1573-0646
    Keywords: mitoxantrone ; acute leukemia ; phase II study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A phase II study of mitoxantrone (Novantrone®; dihydroxyanthracenedione) was conducted in 35 patients (22 male: 13 female) with acute leukemia. There were 35 evaluable cases with a mean age of 34 (range 8–61). Twenty-eight patients had acute non-lymphocytic leukemia (ANLL) and seven had acute lymphocytic leukemia (ALL). Mitoxantrone was administered intravenously 2–4 mg/m2 daily for five days and after the nadir a further 2–3 doses were added if necessary. All previously treated cases (22 patients) had been treated with anthracyclines; 13 had no previous treatment. Out of the 13 untreated cases there were six complete remissions (CRs) (46.2%) and five partial remissions (PRs) (38.5%), while out of 22 pretreated cases, four CRs (18.2%) and five PRs (22.7%) were obtained. In seven of the untreated cases the decrease of leukemic cells and neutrophil leukocytes were analysed. Mitoxantrone showed a longer duration of decrease and higher log decrease of leukemic cells in the bone marrow than daunorubicin or cytosine arabinoside. Seventy-three percent of patients showed gastrointestinal disturbances such as nausea or loss of appetite. In 38.1% SGPT elevation and in 8.8% abnormal ECG findings were observed. All side-effects were mild and reversible. From this data mitoxantrone seems a very promising agent in the treatment of acute leukemia and a phase III study is now being carried out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00174170
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