ISSN:
1860-1499
Keywords:
Murine model
;
Glomerulosclerosis
;
GBM alteration
;
Proteinuria
;
Dense deposits
;
Electron microscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Renal pathology of the FGS/Nga strain of mice, which has been known to develop proteinuria and progressive glomerulosclerosis, was studied by light and electron microscopy. Sclerotic changes had increased by 6 months and most of the glomeruli were totally obsolescent by 10 months. By electron microscopy, electron dense deposits were seen in the mice by 3 months and thereafter. Splitting or the irregular thickening of the glomerular basement membrane (GBM) was observed, and some mice showed reticulation in the GBM. The fixed negative charges detectable with polyethyleneimine (PEI) were decreased in the mice with massive proteinuria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02348834
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