ISSN:
1435-5922
Schlagwort(e):
chronic hepatitis C
;
interferon therapy
;
hemophilia
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Seven patients with chronic hepatitis C, six hemophiliacs and a patient with von Willebrand's disease, were treated with interferon-alpha (IFN-alpha). Either 9 MU of recombinant IFN-alpha 2a or 3 MU of lymphoblastoid alpha-IFN was administered daily for 2 weeks and then three times a week for 22 weeks. Liver histology, hepatitis C virus (HCV) genotypes, and HCV-RNA levels in sera were investigated in all of the patients before IFN therapy was instituted. Liver histology was classified by the European classification. HCV genotyping conformed to the so-called Okamoto's classification. HCV-RNA levels in sera were quantitated by competitive polymerase chain reaction, using mutant RNA. Liver histology, HCV genotype, and serum HCV-RNA level (copies/ml) in each patient were: patient 1, chronic persistent hepatitis, type II, 3×103 respectively; patient 2, chronic active hepatitis (CAH) 2a, type III, 6×104; patient 3, CAH2a, type IV, 2×105; patient 4, CAH2b, type I, 2×107; patient 5, CAH2b, type II, 8×104; patient 6, CAH2b, type III, 7×106; and patient 7, CAH2b, type IV, 1×107. Sustained elimination of HCV was achieved in patient 3 and temporary elimination was achieved in patients 1 and 2. The other patients showed persistent HCV-RNA positivity in sera both during and after IFN treatment. Poor responsiveness to IFN was observed in patients with relatively progressive liver histology and high levels of HCV viremia.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02347513
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