ISSN:
1573-8221
Keywords:
nude mice
;
beige nude mice
;
xenotransplants
;
metastases
;
monoclonal antibodies
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Seven human solid tumor cell lines transplanted into hereditarily immunodeficient mice (nude and beige/nude) were typed for tumor-associated surface antigens and glycoconjugates using fluorescent conjugates of 7 monoclonal antibodies, 5 lectins, and 2 ligands. With this set of 14 selected tumor markers, peripheral blood samples from mice bearing the respective tumors were examined by flow cytofluorimetry for the presence of tumor cells disseminated in their circulation. Tumor cells were detected in the blood of mice carrying a uterine tumor, indicating that the metastatic process can be followed intravitally in immunodeficient animals bearing human solid tumors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445580
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