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  • 1
    Electronic Resource
    Electronic Resource
    Restimulation in Secondary MLC by Autologous Non-T Cells (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 9 (1979), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Lymphocytes sensitized in mixed leucocyte culture (MLC) were restimulaied with non-T or complete cells. Cells primed against autologous non-T cells and restimulated with autologous cells gave responses with the kinetics of a secondary response. In contrast, cells primed against either type of autologous cell responded to restimulation by allogeneic cells with the kinetics of a primary MLC response. Following priming against alloantigens good secondary responses against both complete and non-T allogeneic restimulators were seen. Restimulation with auto-logous non-T colts, but not autologous complete cells, also led to secondary responses. The observation of” different responses to antigens expressed on non-T autologous lymphocytes, in comparison to complete cells, implies that the secondary MLC involves more than a response against alloantigen. Allogeneic and autologous MLC may he qualitatively different phenomena. the latter representing the recognition of identifying structure's between interacting populations of cooperating cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1979.tb03276.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Secondary Responses of Human Lymphocytes to Alloantigens In Vitro (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 4 (1975), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The secondary response of human lymphocytes following restimulation with alloantigens has been studied. If fresh stimulating cells are added to a mixed leukocyte culture (MLC) at a time when the peak of proliferative and cytotoxic activity has passed, a rapid reactivation occurs. The secondary response in MLC demonstrates specificity such that restimulation with the original sensitizing cell (or one presumably sharing the LD genetic determinants responsible for triggering MLC) induces a greater proliferative response than a third-party cell. On the other hand, the secondary cytotoxic response is directed towards the SD antigens of the original sensitizing cell regardless of which cell is used for restimulation. Possible mechanisms of cellular interactions are considered to explain these results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1975.tb02667.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    IL-2 gene therapy of solid tumors: an approach for the prevention of signal transduction defects in T cells (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 127-134 
    Details
    ISSN: 1432-1440
    Keywords: Key words Gene therapy ; Interleukin 2 ; T cells ; Immune suppression ; Signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The identification of tumor-associated antigens has focused attention on the mechanisms that underlie the failure of T cells to destroy tumor cells. A deeper understanding of the process of signal transduction following the binding of ligand by the T cell receptor can help to identify underlying defects that may be involved. Gene therapy using tumor cells genetically modified to express cytokines or surface determinants is a promising technique for stimulating antitumor responses. A potential pitfall in its application to cancer, however, is that some patients’ T cells are immune suppressed and may resist stimulation by such genetically engineered vaccines. Recent studies have demonstrated that T cells from tumor-bearing patients exhibit abnormalities in signal transduction events, possibly rendering them unable to respond to activation signals. Gene therapy with interleukin 2 secreting tumor cells in an animal model has been shown effective in preventing the onset of signaling defects. A more precise definition of the molecular mechanisms that enable cytokine-secreting tumor cells to stimulate specific antitumor responses may make it feasible to optimize immunotherapeutic approaches resulting in better clinical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575444
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    IL-2 gene therapy of solid tumors: an approach for the prevention of signal transduction defects in T cells (1996)
    Springer
    Journal of molecular medicine 74 (1996), S. 127-134 
    Details
    ISSN: 1432-1440
    Keywords: Gene therapy ; Interleukin 2 ; T cells ; Immune suppression ; Signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The identification of tumor-associated antigens has focused attention on the mechanisms that underlie the failure of T cells to destroy tumor cells. A deeper understanding of the process of signal transduction following the binding of ligand by the T cell receptor can help to identify underlying defects that may be involved. Gene therapy using tumor cells genetically modified to express cytokines or surface determinants is a promising technique for stimulating antitumor responses. A potential pitfall in its application to cancer, however, is that some patients' T cells are immune suppressed and may resist stimulation by such genetically engineered vaccines. Recent studies have demonstrated that T cells from tumor-bearing patients exhibit abnormalities in signal transduction events, possibly rendering them unable to respond to activation signals. Gene therapy with interleukin 2 secreting tumor cells in an animal model has been shown effective in preventing the onset of signaling defects. A more precise definition of the molecular mechanisms that enable cytokine-secreting tumor cells to stimulate specific antitumor responses may make it feasible to optimize immunotherapeutic approaches resulting in better clinical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01575444
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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