ISSN:
1432-2072
Keywords:
Key words Morphine
;
Butorphanol
;
Subjective
;
Opiate
;
Psychomotor
;
Opioid
;
Analgesia
;
Pain
;
Human
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The purpose of this study was to characterize the effect of a painful stimulus on morphine and butorphanol effects in healthy non-drug abusing volunteers. Thirteen subjects with no history of opiate dependence participated in a randomized, placebo-controlled, double-blind, crossover trial in which each subject received saline, 2 mg/70 kg butorphanol, and 10 mg/70 kg morphine, IV, in each of two conditions, periodic forearm immersions into either ice-cold water (2°C) or into warm water (37°C). Both opioids reduced self-reported ratings of pain intensity, indicative of analgesia. Several of the subjective effects of morphine were attenuated either during or in between cold-water immersions, including visual analog scale ratings of “coasting (spaced out),”“high (drug “high”),”“sleepy (drowsy, tired),” and “lightheaded”. In contrast, some of butorphanol’s subjective effects were increased by the cold-water manipulation. Morphine impaired psychomotor performance during one of the warm-water immersions, but not during the cold-water immersions. Psychomotor impairment induced by butorphanol was not affected by water temperature. This study provides evidence that opioid effects can be modulated by a painful stimulus in humans.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002130050298
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