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  • 1
    Digitale Medien
    Digitale Medien
    Predictive value of congenital hypertrophy of the retinal pigment epithelium as a clinical marker for familial adenomatous polyposis (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 1003-1008 
    Details
    ISSN: 1530-0358
    Schlagwort(e): Familial adenomatous polyposis ; Congenital hypertrophy ; Retinal pigment epithelium ; Extracolonic manifestations
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract One hundred forty-eight members of 53 kindreds with familial adenomatous polyposis (FAP) were examined for congenital hypertrophy of the retinal pigment epithelium (CHRPE) and extracolonic manifestations (ECM) to assess the value of CHRPE as a predictive marker for FAP. Based on eye examination results, the families were divided into 2 groups. In a first group of 34 families, all 61 members diagnosed as having polyps and 13 of the 33 patients at risk had 4 or more lesions distributed in both eyes. By contrast, in a second group of 18 families, all 32 polyposis patients and all 18 members at risk had less than 4 lesions. Extracolonic manifestations were present in 26 of 34 families in the first group and in 11 of 18 families in the second group. Data on one family with ambiguous ancestry were reviewed separately. The existence of 4 or more CHRPE lesions distributed in both eyes seems to be a congenital marker for FAP, present in 65.4 percent of families. When present in a family: 1) it is found in all diagnosed patients in that family, 2) can therefore be considered predictive for the development of polyps in other family members who carry the trait, and 3) if confirmed by longer follow-up, may possibly preclude members without the trait from further evaluation and surveillance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02139213
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  • 2
    Digitale Medien
    Digitale Medien
    Iris fluorescein angiography in diabetic vitrectomy patients (1978)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 206 (1978), S. 17-24 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Präoperative Fluoreszeinangiogramme der Iris von 34 Diabetikern, an denen eine Vitrektomie durchgeführt wurde, wurden mit dem postoperativen Verlauf verglichen. 23 von 24 Patienten, bei denen klinisch keine Rubeosis festgestellt wurde, zeigten Gefäßveränderungen im Angiogramm. Patienten mit eindeutiger Rubeosis im Angiogramm (Grad III and IV) bekamen in 63% der Fälle ein Sekundärglaukom. Sie gehören damit in eine hohe Risikogruppe. Der postoperative Visus bei den Patienten mit Glaukom war schlecht.
    Notizen: Summary Preoperative iris fluorescein angiograms (IFA) and ophthalmic records of 34 diabetic patients who underwent vitrectomy were reviewed. Of 24 patients without clinically apparent rubeosis, 23 showed evidence of iris microvascular abnormalities or rubeosis on IFA. Patients with rubeosis (Grades III and IV) on IFA had a 63% incidence of postoperative neovascular glaucoma, thus isolating them as a high risk group. The visual outcome of patients developing neovascular glaucoma was poor.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00411333
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  • 3
    Digitale Medien
    Digitale Medien
    Severe electrical burn of the eye (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 214 (1980), S. 147-153 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The clinical and histopathologic findings in an 18-year-old male who sustained a severe orbital and ocular electrical burn as a result of contact with a “third rail” are described. The third rail was 600 volts positive with respect to the ground, and a maximum of 50,000 amperes was available as current. The anterior segment changes described are considered secondary to heat, as well as electrical energy; whereas the more discrete pathology in the posterior retina and optic nerve was thought to be caused by the passage of electrical current. Ocular and orbital electrical injuries of this severity have rarely been described.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00414558
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  • 4
    Digitale Medien
    Digitale Medien
    Intraocular reticulum cell sarcoma: A case report and literature review (1979)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 209 (1979), S. 167-178 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary A 66-year-old white woman with a confusing spectrum of central nervous system signs and symptoms had a diagnostic enucleation of her blind left eye showing retinal infiltration. Histopathologic examination showed reticulum cell sarcoma involving the retina. The patient died one month later and autopsy revealed diffuse central nervous system reticulum cell sarcoma along with right eye and systemic involvement. A review of the literature indicates intraocular reticulum cell sarcoma to be an apparently uncommon occurrence, although ocular examination may be frequently overlooked.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00414609
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  • 5
    Digitale Medien
    Digitale Medien
    Retinal anomalies in trisomy 18 (1980)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 213 (1980), S. 195-205 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Die Augen von drei Patienten mit Trisomie 18, die zweithäufigste menschliche autosome Trisomie, wurden histopathologisch untersucht. Transmission- und rasterelectronmikroskopische Befunde zeigen zytologische Einzelheiten in der hinteren Netzhaut, die für unreife Neuralretina charakteristisch sind. Wir sind in der Lage das Ergebnis zu bestätigen, daß bei der Trisomie 18 das Pigmentepithel der hinteren Netzhaut einen Mangel an reifen Malanosomen aufweist und dem Netzhautpigmentepithel eines menschlichen Albinos ähnelt. Der Zusammenhang zwischen Hypopigmentierung und unreifer Netzhaut legt nahe, daß bei der Kontrolle des Reifungsprozesses der Neuralretina die Pigmentierung eine Rolle spielt.
    Notizen: Abstract The eyes of three patients with trisomy 18, the second most common human autosomal trisomy, were examined histopathologically. In the posterior retina transmission and scanning electron microscopic examinations reveal cytological details characteristic of immature neural retinas. We are able to confirm the report that the posterior retinal pigment epithelium in trisomy 18 has a paucity of mature melanosomes and, in fact, resembles human albino retinal pigment epithelium. The association of hypopigmentation and retinal immaturity suggests pigmentation plays a role in the control of the maturation of the neural retina.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00410989
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