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  • 1
    Electronic Resource
    Electronic Resource
    Dendritic cell number is related to IL-4 expression in the airways of atopic asthmatic subjects (2000)
    Copenhagen : Munksgaard International Publishers
    Allergy 55 (2000), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Airway dendritic cells are essential for stimulating naive T cells in response to inhaled antigen and for the development of allergic sensitization. IL-4 in vitro can distinguish dendritic cell lines from peripheral blood mononuclear cells. Our study had the following aims:〈list xml:id="l1" style="custom"〉to compare the distribution of CD1a+ dendritic cells and IL-4+ cells, in the bronchial mucosa of asthmatics and controlsto determine the relationship between the numbers of CD1a+ dendritic cells and IL-4+ cells in the bronchial mucosa of asthmaticsto determine whether CD1a+ cells express the IL-4 receptor. Methods: Twenty atopic asthmatic and eight normal subjects were studied. In each subject, bronchoscopy with bronchial biopsies was performed. CD1a, IL-4, and IL-4 receptor expressions were evaluated by immunohistochemistry. Results: The number of CD1a+ and IL-4+ cells was significantly higher in asthmatics than controls. The number of CD1a+ cells was positively correlated to the number of IL-4+ cells. Bronchial biopsy serial section studies showed that CD1a+ cells express the receptor for IL-4. Conclusions: These results suggest that an increased amount of IL-4 may play a physiopathologic role in maintaining the dendritic cell pool in vivo. Therefore, because of possible IL-4 activity on antigen-presenting cells in T-cell immune responses to allergens, an important new role of IL-4 in asthma inflammation can be envisaged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2000.055005449.x
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  • 2
    Electronic Resource
    Electronic Resource
    Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis (2002)
    Oxford, UK : Blackwell Science, Ltd
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Eosinophils and T lymphocytes represent constant features in the airways of subjects with exacerbated chronic bronchitis. Eotaxin is the most potent and selective eosinophil chemoattractant which can also attracts lymphocytes. The aim of the study was to evaluate the expression of eotaxin and its receptor, CCR3, in bronchial airways during exacerbation of chronic bronchitis. Methods: By immunohistochemistry we studied eotaxin and CCR3 expression in the lamina propria of 14 subjects with acute exacerbation of chronic bronchitis, 20 asthmatics, and 8 healthy subjects. We determined the cell types expressing the CCR3 receptor by colocalization experiments. We finally studied the relationship between eotaxin and CCR3 and eosinophils and T lymphocytes. Results: The number of eotaxin+ and CCR3+ cells was significantly higher in exacerbated chronic bronchitis (P 〈 0.003 and P 〈 0.002) and asthma (P 〈 0.002 and P 〈 0.0001) when compared to healthy subjects. CCR3 was mainly expressed by eosinophils and to a lesser extent by CD4+ and CD8+ lymphocytes. In exacerbated chronic bronchitis the number of CCR3+ cells was strongly correlated to the number of eosinophils (P 〈 0.0002, r = 0.85) and to the number of CD4+ lymphocytes (P 〈 0.05, r = 0.57). Conclusion: Our study suggests that eotaxin and CCR3 are up-regulated and could be involved in the eosinophil and CD4+ lymphocyte recruitment into the airways which occur during acute exacerbations of chronic bronchitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0105-4538.2001.00001.x-i7
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  • 3
    Electronic Resource
    Electronic Resource
    Involvement of polyamines in gibberellin-induced development of seedless grape berries (1998)
    Springer
    Plant growth regulation 25 (1998), S. 187-193 
    Details
    ISSN: 1573-5087
    Keywords: gibberellic acid ; grape berry development ; putrescine ; spermidine ; spermine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The roles of polyamines (PAs) in the development of seedless grape berries induced by gibberellin (GA3) was investigated. The development of seedless grape berries was stimulated by the application of putrescine (Put), but not by that of spermidine (Spd) and spermine (Spm), regardless of the presence of GA3. At harvest, the fresh weight of seedless grape berries treated with 500 ppm Put + 25 ppm GA3 and 500 ppm Put increased to 111 and 112%, respectively, of the control. Treatment with methylglyoxal-bis (guanyl hydrazone), a potent inhibitor of S-adenosylmethionine decarboxylase that plays a role in Spd and Spm synthesis, did not affect the development of seedless grape berries induced by 100 ppm GA3. The application of 100 ppm GA3 significantly increased endogenous free Put levels. Levels of free Spd and Spm were not affected by GA3. Although the levels of endogenous perchloric acid insoluble bound PAs were higher than those of free PAs, obvious changes in the levels of bound PAs were not observed. These results indicate that free Put is implicated in the development of seedless grape berries induced by GA3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006043116190
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