Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of Na+-independent [3H]GABA binding to synaptic membranes of rat brain by β-substituted GABA derivatives (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 32 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb04605.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Effect of various GABA-receptor agonists and antagonists on anaphylactic histamine release in the guinea-pig ileum (1987)
    Springer
    Inflammation research 20 (1987), S. 181-184 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this paper we confirm the previously reported inhibition by GABA of anaphylactic histamine release from isolated guinea-pig ileum longitudinal muscle. Moreover we report that: A) GABA-inhibition of anaphylactic histamine release is mimicked both by GABA-A and GABA-B agonists; both GABA-A and GABA-B antagonists are effective in reversing GABA's inhibitory effect; B) the effect is exerted specifically by GABA-ergic drugs: taurine and β-alanine are ineffective; C) the GABA-ergic effect seems not to involve cholinergic and adrenergic transmission. It is concluded that it might be interesting to assess the clinical value of GABA-ergic drugs in allergic gut disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02074663
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Capsaicin and anaphylactic reactions in the guinea-pig (1989)
    Springer
    Inflammation research 27 (1989), S. 166-168 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of capsaicin on anaphylactic reactions in the guinea-pig was studied bothin vivo andin vitro. In guinea-pigs actively sensitized with ovalbumin, Herxheimer microshock was elicited by antigen aerosol and the preconvulsion time recorded. The preconvulsion time was reduced by about 30% in animals pretreated with capsaicin (1 mg/kg) injected i.p. 30 min before antigen aerosol, whereas it remained unchanged when the drug was administered two days before aerosol treatment. Capsaicin shows a partial protective effect when the provocative aerosol was administered 3 h after the last of three doses of capsaicin (100 μg/kg, i.p.), which had been injected for three consecutive days. Ileum longitudinal muscle strips were used forin vitro anaphylaxis studies. These were isolated from guinea-pigs actively sensitized with ovalbumin and histamine release evoked by antigen was measured. Preparations perfused with capsaicin (10−6–10−4 M) and desensitized to the drug, showed a lower anaphylactic release of histamine. This effect was dose-dependent, with the histamine release reduced by 35% at higher concentrations (10−5–10−4 M) of capsaicin. The mechanism of the influence of capsaicin on anaphylactic reactions is discussed briefly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222229
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Histamine uptake and metabolism in smooth muscle in vitro (1978)
    Springer
    Inflammation research 8 (1978), S. 408-408 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01968657
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Capsaicin and anaphylactic reactions in the giunea-pig airways (1990)
    Springer
    Inflammation research 30 (1990), S. 92-94 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Further evidence is reported on the influence exerted by capsaicin on the anaphylactic reaction evoked in actively sensitized guinea-pigs. In Herxheimer microshock induced by ovalbumin aerosol, pretreatment of animals with 100 μg/kg i. p. capsaicin prolonged the preconvulsion time when the drug was administered 3 h before antigen challenge. In contrast, the same dose of capsaicin injected 30 min before aerosol caused a shortening of latency of the respiratory symptomatology. The influence of the drug is no longer evident after 24 h. In “in vitro” experiments desensitization to capsaicin of tracheal preparations caused a reduction of histamine and SRS-A released during antigen challenge, in comparison to controls. Moreover, anaphylactic histamine release was increased in preparations perfused with 10−8 M substanceP. In conclusion, our findings confirm that neuropeptides may be involved in the pathogenesis of asthma by affecting release of mediators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969007
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Uptake and metabolism of histamine in guinea pig ileal longitudinal muscle (1978)
    Springer
    Inflammation research 8 (1978), S. 462-469 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dose dependent [14C]-histamine uptake is shown in ileal longitudinal muscle of the guinea pig in vitro; [14C]-radioactivity taken up is found only in part as unmodified histamine (7.9%) and for the remainder as histamine metabolites (N-methylhistamine 12.3% and acid metabolites 79.8%). This process is not affected by mast cell depletion obtained by means ofn-octylamine treatment. Theophylline and 3-isobutyl-1-methylxanthine (IMX) facilitate [14C]-histamine uptake, while α-aminoguanidine inhibits it. Facilitation of histamine uptake by theophylline and IMX does not correlate with their ability to interfere with cAMP phosphodiesterase activity. While the first substance inhibits this activity, IMX, on the other hand, potentiates it. Variations of [14C]-histamine uptake parallel variations of [14C]-histamine metabolism: so an increase of [14C]-histamine uptake in the presence of theophylline or IMX is accompanied by an increase of acid metabolites, while in the presence of α-aminoguanidine, which inhibits [14C]-histamine uptake, a decrease of acid metabolites is observed. The hypothesis is advanced that levels of unmodified histamine cause variations of negative feed-back on the transport system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02111429
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Inhibition of cholinergic histamine release in rat mast cells (1980)
    Springer
    Inflammation research 10 (1980), S. 139-140 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Adrenaline inhibits the acetylcholine-evoked histamine release from isolated purified rat mast cells, in a dose-dependent fashion. The inhibitory effect of adrenaline is reversed by preincubating the cells with a beta-blocker, alprenolol, but not by preincubating them with an alpha-blocker, phentolamine. These results were confirmed by observations using an electron microscope and they suggest that adrenaline inhibits the cholinergic histamine release from rat mast cells acting upon beta-receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024196
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Lipid peroxidation induced “in vivo” by iron-carbohydrate complex in the rat brain cortex (1991)
    Springer
    Neurochemical research 16 (1991), S. 43-49 
    Details
    ISSN: 1573-6903
    Keywords: Iron-carbohydrate complex ; brain lipid peroxidation ; scavenger ; metal-chelating agents
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In view of the emerging role of metals and particularly iron in the pathogenesis of several ischemic or degenerative CNS diseases, via a lipid peroxidative process, a model of slow iron-induced peroxidative damage in the rat brain cortex has been carried out. Iron-carbohydrate complexes were injected in the right brain cortex, and biochemical assays were performed on ipsilateral and contralateral samples two hours or seven days after injection. Iron-sacchararate caused a significant increase in the ipsilateral cortex in TBARS, conjugated dienes and fluorescent substances seven days after injection, whereas no biochemical alteration was observed two hours after treatment. In order to prevent or to limit lipid peroxidation, some drugs known for chelating and/or scavening activity were administered to iron-injected rats. DL-α-tocopherol, methylprednisolone, D-penicillamine significantly decreased the value of fluorescent products formed by iron-saccharate, whereas desferrioxamine was not effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00965826
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    D-penicillamine affects lipid peroxidation and iron content in the rat brain cortex (1992)
    Springer
    Neurochemical research 17 (1992), S. 1241-1246 
    Details
    ISSN: 1573-6903
    Keywords: d-Penicillamine ; iron ; iron-carbohydrate complex ; brain lipid peroxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract d-Penicillamine, a trifunctional aminoacid known for its ability to form metal complexes and for being a radical scavenger, has been investigated “in vitro” and “in vivo” in the rat brain cortex. At 50 μM the drug facilitate lipid hydroperoxides and TBARS formation in brain cortex homogenates, while at higher concentrations a clear inhibition of the lipid peroxidative process was observed. The activity of thed-penicillamine (25 and 50 mg/Kg i.p) was evaluated “in vivo” after a 7-day treatment in rats in whose brain cortex a slow process of lipid peroxidation was induced by iron-saccharate injection. Lipid hydroperoxides, lipid soluble fluorescent compounds and the iron content of both iron-injected and contralateral hemicortices showed a significant decrease in comparison to rats untreated withd-penicillamine. The higher dose also induced in normal rats a significant decrease in basal TBARS and iron content of the brain cortex. In the iron-injected cortex the observed Fe2+/Fe3+ ratio was significantly different from that of normal rats. On the contrary ratios obtained formd-penicillamine treated animals were higher in comparison to both normal and iron-injected animals. These results suggest thatd-penicillamine, acting as a reducing agent, inhibits the iron redox system and, as a chelating agents, can remove metal from action sites where lipid peroxidation may occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968407
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...