Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    How many endomyocardial biopsies are necessary in the first year after heart transplantation? (1996)
    Springer
    Transplant international 9 (1996), S. 243-247 
    Details
    ISSN: 1432-2277
    Keywords: Heart transplantation, endomyocardial biopsy ; Biopsy, endomyocardial ; Endomyocardial biopsy, heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since 1989, the immunosuppressive regimen used in all heart transplant (HTx) patients at our center has consisted of a combination of cyclosporin, azathioprine, and prednisone. No prophylactic cytolytic agents have been given. One hundred consecutive patients were followed for periods of 4–56 months (mean 27 months). The incidence of rejection was so low in the initial 18 patients that we felt confident about reducing the number of routine endomyocardial biopsies (EMBs) that were performed. The mean number of EMBs in this subgroup was 10 (median 11). In the next 20 patients, EMB was performed routinely on only three occasions during the 1st post-transplant year (at 2, 4, and 8 weeks). In the subsequent 62 patients, EMB was performed on post-transplant days 10, 20, 30, and 60. Further EMBs were performed after acute rejection episodes had been treated. No noninvasive methods of diagnosing rejection were employed. In 82 consecutive patients, therefore, the mean number of EMBs within the 1st year was five per patient (median four), with 58% undergoing fewer than five EMBs and 25% requiring more than five EMBs. In the entire group of 100 patients, the mean number of EMBs was 5.9. The incidence of acute rejection requiring increased therapy was 24%. Only 7% required i.v. steroids, two of whom (2%) also required ALG and/or OKT3, with 17% requiring increased oral immunosuppression alone. Actuarial survival was 98% at 30 days, 94% at 1 year, and 92% at 2 years. It is possible that we may have missed acute rejection episodes that resolved spontaneously. However, the excellent mediumterm results would suggest that any such rejection episode did not progress to become hemodynamically significant. It may be, therefore, that when an effective immunosuppressive regimen is utilized, the number of EMBs performed at many centers is excessive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335393
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Primary bronchogenic carcinoma in recipients of heart transplants (1997)
    Springer
    Transplant international 10 (1997), S. 312-316 
    Details
    ISSN: 1432-2277
    Keywords: Key words Bronchogenic carcinoma ; heart transplantation ; Heart transplantation ; bronchogenic carcinoma ; Immunosuppression ; bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With the exception of carcinomas of the skin and lip, carcinoma of the bronchus is the most common carcinoma that afflicts recipients of solid organ grafts. Of 859 tumors occurring in 830 recipients of thoracic organs reported to the Cincinnati Tumor Transplant Registry, 242 were carcinomas and 68 of these were bronchogenic carcinomas, which therefore made up 8 % of the overall total. There are, however, relatively few reports of heart transplant patients with bronchogenic carcinoma in the literature. We present details of four patients who developed this malignancy out of a total of 196 patients who survived and have been followed up for more than 3 months at our center, an incidence of 2 %. The mean period from the time of transplant to diagnosis of malignancy was 58 months (range 11–82 months). The histology was squamous or anaplastic in three cases, and adenocarcinoma in one. Immunosuppressive therapy was reduced in all cases. Resection was carried out in two patients (both of whom died 6 and 11 months later, respectively), resection was combined with chemotherapy and radiation in one patient (alive 15 months later), and therapy consisting of radiation alone was given to one patient (died within 1 month). We conclude that bronchogenic carcinoma is relatively common in patients with heart transplants and that it has a poor prognosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001470050062
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Binding and specificity of major immunoglobulin classes of preformed human anti-pig heart antibodies (1993)
    Springer
    Transplant international 6 (1993), S. 351-353 
    Details
    ISSN: 1432-2277
    Keywords: Antibodies, human, preformed ; Pig cells, anti-pig immunoglobulins ; Hyperacture rejection, pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Preformed human anti-pig antibodies isolated from perfused pig hearts were used to analyze the binding of various immunoglobulin classes to cultured pig kidney cells. All anti-pig immunoglobulins (i.e., IgG, IgA, and IgM) were localized on the cell surface by the use of an indirect immunofluorescence technique. Anti-pig immunoglobulins also competed for the pig cell surface epitopes with Griffonia simplicifolia lectin (GS-I-B4), which is specific for α-galactosyl residues. This study provides further evidence that preformed human antibodies recognizing α-glactosyl-containing epitopes (anti-gal antibodies) could be an important factor in hyperacute rejection of pig organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335975
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A comparison of organ transplant patient and professional staff attitudes (1995)
    Springer
    International journal of rehabilitation and health 1 (1995), S. 167-178 
    Details
    ISSN: 1573-1537
    Keywords: organ transplantation ; patient-staff attitudes ; psychosocial selection criteria ; mutual role expectations ; communication style
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Although most health care professionals acknowledge the importance of collaboration and team work between patients and staff in organ transplantation (TX), there is a scarcity of research exploring the nature of staff-patient relationships. We surveyed 204 TX-patients and professional staff (n=83 patients,n=121 staff) and compared their attitudes with regard to (a) psychosocial selection criteria of patients being assessed for organ TX, (b) patient and staff role expectations, and (c) communication styles in relation to organ TX. Our findings indicate overall agreement between patients and staff with regard to the importance of (a) family and social support, (b) current alcohol and drug abuse, and (c) patient noncompliance as factors to consider in the selection of candidates for TX. Attitudes and beliefs did not relate to demographic factors, years of experience (staff), or type of TX (patients and staff). Patients had higher expectations of nursing care and of shared patient-nurse roles than did staff (p〈0.001). Assessment of communication style found that collaboration was the least used style, while avoidance of communication and accommodation were the most common. Nurses, social workers, and chaplains were more willing to compromise than were patients and physicians (p〈0.001). We conclude that for TX patients and staff (a) there is general agreement with regard to the psychosocial criteria that are important in the selection of patients for organ TX; (b) post-TX misunderstandings may occur due to conflicting opinions about role responsibility, with patients (and physicians) having significantly stronger beliefs in the “equality” of role relationships than did other staff; and (c) resolution of problems is not collaborative in nature, or is unlikely to result in compromise, but instead is either a passive avoidance or an accommodation to satisfy others. These aspects of patient-staff relationships require further attention if TX programs are to obtain optimal results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02214729
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...