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INTERLEUKIN-10 AND THE INTERLEUKIN-10 RECEPTOR (2001)

Moore, Kevin W. ; de Waal Malefyt, Rene ; Coffman, Robert L. ; [et al.]

Palo Alto, Calif. : Annual Reviews

Annual Review of Immunology 19 (2001), S. 683-765

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ISSN: 0732-0582

Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Topics: Biology , Medicine

Notes: Abstract Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on most hemopoietic cell types. The principal routine function of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In addition to these activities, IL-10 regulates growth and/or differentiation of B cells, NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and function of a newly appreciated type of T cell, the T regulatory cell, which may figure prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic cytokines, IL-10 has closely related homologs in several virus genomes, which testify to its crucial role in regulating immune and inflammatory responses. This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1146/annurev.immunol.19.1.683

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IL-12 and IL-23: master regulators of innate and adaptive immunity (2004)

Langrish, Claire L. ; McKenzie, Brent S. ; Wilson, Nicholas J. ; [et al.]

Oxford, UK; Malden, USA : Munksgaard International Publishers

Immunological reviews 202 (2004), S. 0

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ISSN: 1600-065X

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Summary: Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell-derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)-23, a new member of the IL-12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL-12 and IL-23 promote two distinct immunological pathways that have separate but complementary functions. IL-12 is required for antimicrobial responses to intracellular pathogens, whereas IL-23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression.