ISSN:
0899-0042
Keywords:
Saccharomyces cerevisiae
;
asymmetric β-keto-ester reduction
;
enzymatic kinetic resolution
;
chiral 2-allyl-2-carboethoxy-cyclopentanol
;
chiral high resolution gas chromatography
;
chiral stationary phase
;
β-cyclodextrin derivative
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The improvement of the biocatalytic reduction of 2-allyl-carboethoxy-cyclopentanone (2) to the corresponding cyclopentanol derivative (+)-(1R,2R)-(1) was accomplished employing baker's yeast in organic media. This chiral cyclopentanol derivative (1), analyzed by high resolution gas chromatography performed over β-cyclodextrin stationary phase, was obtained in 38% yield (〉99% e.e.). Chirality 9:321-324, 1997. © 1997 Wiley-Liss, Inc.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
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