ISSN:
0021-9304
Keywords:
poly(DL-lactide-ε-caprolactone)
;
degradation
;
foreign body reaction
;
subcutaneous implant
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
The aim of this study was to evaluate the degradation and foreign-body reaction of poly(DL-lactide-ε-caprolactone) (PLA85CL50) bars. This specific biomaterial is used for the construction of nerve guides, which can be used in the reconstruction of short nerve gaps. Subcutaneously implanted PLA85CL50 bars were harvested after implantation periods ranging from 3 to 12 months and evaluated for the rate of degradation and the degree of foreign-body reaction. It was observed that this copolymer degraded completely within 12 months and that no lactide or ε-caprolactone crystals were formed. Furthermore, we conclude that the foreign-body reaction of PLA85CL50 is very mild. These properties make the amorphous copolymer of DL-lactide and ε-caprolactone (50:50) suitable for the construction of nerve guides. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 36, 337-346, 1997.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
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