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  • 1
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Depuis septembre 1986 jusqu’à decembre 1992 quatre-vingt huit patients presentant les lésions cartilagineuses au genou ont été traité par arthroplastie périchondrale. Dans les lésions, une partie du périchondre de la côte a été fixé avec de la colle de fibrine. Les soins consécutifs consistaient à une immobilisation, une mobilisation passive, et a une mise en charge partielle puis complète. L’évaluation des résultats a été fait avec l’aide de la cotation Hospital for Special Surgery pour l’articulations du genou, par examen radiologique, arthroscopie postoperatoire et recueil de l’opinion subjective du patient. Les résultats après une étude moyenne de cinquante deux mois ont été bon à 38%, modéréà 8% et mauvais à 55%. Les contre-indications pour cette technique sont des forages ou nettoyages précédents, l’arthrose, l’âge avancé du patient, et des douleurs préexistantes. Des bons résultats sont vus dans les lésions isolées à 91% (30/33). Nous concluons que l’arthroplastie avec périchondre peut être favorable pour réparer des lésions cartilagineuses. Cette technique peut diminuer les douleurs des patients bien sélectionnés et prévenir les opérations plus compliquées pour arthrose.
    Notes: Summary. Eighty-eight patients with articular cartilage defects in the knee were treated by perichondrial arthroplasty between 1986 and 1992. An autogenous strip of costal perichondrium was fixed in place with fibrin glue, followed by immobilisation, continuous passive motion, and partial weightbearing. The results were evaluated using the Hospital for Special Surgery Score for knee function, radiographs, arthroscopy and the patient’s subjective opinion. The results after a mean follow-up of 52 months were good in 38%, fair in 8% and poor in 55%. Previous drilling or shaving of a defect, concomitant osteoarthritis, older age and a long history of complaints proved to be contraindications. Good results were seen in 91% of isolated defects. Perichondrial arthroplasty can be beneficial in the repair of cartilage defects. It will reduce symptoms in carefully selected cases, and avoid more extensive operations for osteoarthritis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of materials science 9 (1998), S. 749-754 
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Tissue engineering of articular cartilage in order to restore the function of degenerated, diarthrodial joints is currently widely under investigation. The results obtained thus far indicate that proper control of the differentiation of the cells used for this purpose is essential to produce and maintain a hyaline-like matrix. In this study, a procedure is described by which differentiation of chondrocytes in vitro and ex vivo can be studied. The method involves quantitative assessment of mRNA for different collagens, which are markers for differentiation of chondrocytes, by competitive PCR. In a culture system employing human osteoarthritic chondrocytes, mRNAs for the α1-chains of collagen types I, II and X are quantified. The procedure is fast, specific and sensitive. However, several controls should be included to ascertain the reliability of the assessment. © 1998 Kluwer Academic Publishers
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The quantity of bone formed in cylinders of a newly developed erodible copolymer, PolyactiveTM (PA60/40) was examined. PA60/40 was implanted in three different bone locations in the rabbit: in the cortex, in bone marrow and in trabecular subchondral bone. Bony ingrowth was assessed after 4, 8, 26 and 52 w after the operation and investigated by histology and image analysis. The ingrowth of bone was observed in PA60/40 placed in the cortex from 4 w onwards. After 8 w, more than 90% of the pores of the biomaterial were filled with dense bone. In bone marrow, initially some bone formation was seen. After 26 w, all newly formed bone was resorbed. Subchondral bone formation was less than in the cortex of the femur, but somewhat comparable to the amount of bone found in healthy trabecular bone. Bone formation appeared not to be affected by the degradation of the biomaterial. It was concluded that PolyactiveTM is a suitable bone graft substitute. Bone formation within PA60/40 is site-dependent and this follows Wolff 's law. © 1998 Chapman & Hall
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The biocompatible, osteoconductive and resorbable polymer PolyactiveTM (PA) was investigated for its performance as a bone-graft substitute. The model consisted of a 4 mm borehole, 1.5 cm distal of the major trochanter in both femurs of a rabbit, of which one was filled with a cylinder of porous PA. The other was left untreated. PA70/30 and PA60/40 were investigated, both before and after being incubated with allogenic bone marrow. Analyses were performed after 4, 8, 26 and 52 weeks and comprised dual energy X-ray absorptiometry (DXA) and image analysis of histological sections. DXA revealed an increased bone mineral density in the filled defects compared to the controls, both at the defect and immediately proximal and distal of the defect. Histology showed that gap-bridging had occurred within 8 weeks, with 80%–90% of the pores of PA70/30 and PA60/40 occupied by new bone, and an intimate bone–PA contact. PA70/30 seemed to be more suitable compared to PA60/40, in that the highest amount of bone was formed within the shortest period of time. Incubation of PA with allogenic bone marrow resulted in inflammatory reactions at the sites of implantation, which delayed bone growth, but did not prevent it. It was concluded that PA70/30 and PA60/40 are suitable bone-graft substitutes.
    Type of Medium: Electronic Resource
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