ISSN:
1432-1084
Keywords:
Key words: Thalassemia
;
Extramedullary hematopoiesis
;
MRI
;
CT
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract. Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of β-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s003300050926
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