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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mammary-like glands are a poorly recognized structure of the normal vulvar skin. Adenocarcinomas occur rarely in these glands and represent a distinct clinicopathologic entity that must be distinguished from metastatic tumors. We present a case of a 51-year-old patient with a long-standing nodule on her right labium majus. Excision with subsequent Mohs micrographic surgery revealed an infiltrating adenocarcinoma of the mammary-like glands involving the dermis and subcutis. We review all cases thus far reported (including the case presented herein) and identify important clinical and morphologic features of this tumor. A significant histopathological and immunohistochemical overlap between this neoplasm, sweat gland carcinomas, and invasive extramammary Paget’s disease was recognized; suggesting the existence of a morphologic spectrum between these entities. Criteria for establishing the diagnosis of adenocarcinoma of mammary-like glands are reviewed, including the importance of identifying transition zones between normal mammary-like glands and malignant glands. We believe that this tumor is best categorized as a locally aggressive neoplasm with a low metastatic potential and death from disease is uncommon. The successful treatment of this case by Mohs micrographic surgery suggests that an alternate management approach may be adopted for these tumors, particularly in elderly patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dimorphic fungal infections (histoplasmosis, blastomycosis, coccidiomycosis, and cryptococcosis) can occur in immunocompromised and healthy individuals. Cutaneous involvement is often secondary and may be the presenting sign of systemic disease. These ominous infections are frequently clinically indistinct and their prognosis is influenced by their timely diagnosis and treatment. Morphological differentiation between these organisms is not definitive and tissue cultures represent the diagnostic gold standard in current day practice. However, not uncommonly tissue cultures are not obtained and merely represent an afterthought in seemingly unsuspecting cases. Furthermore, when performed, they may take several days to weeks for completion. In situ hybridization (ISH) utilizing oligonucleotide probes directed against fungal ribosomal RNA represents a rapid and accurate assay for the diagnosis of dimorphic fungi in paraffin-embedded tissue sections. We present 7 patients in whom ISH both prospecitively and retrospectively confirmed the presence of a cutaneous infection (2 histoplasmosis, 2 blastomycosis, 1 coccidiomycosis, 2 cryptococcosis). In all of the skin sections analyzed, dimorphic fungi were morphologically apparent but not diagnostically discernable. In summary, ISH represents a valuable tool in the prompt diagnosis of cutaneous deep fungal infections.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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