ISSN:
1059-910X
Keywords:
Cytoskeleton
;
Steroidogenesis
;
Mitochondrial development
;
Gap junctions
;
Haras Oncogene
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Natural Sciences in General
Notes:
Granulosa cells, which nurse the oocyte and serve as a major source for estradiol and progesterone production, undergo major morphological changes which correlate very well with modulation of their steroidogenic capacity. These include changes in intercellular contacts and communication, in cell membrane receptors, and in the development and organization of organelles associated with steroidogenesis (i.e., mitochondria, smooth endoplasmic reticulum, lipid droplets, and lysosomes). These biochemical and morphological changes can also be obtained in primary cultures as well as in oncogene transformed granulosa cell lines established recently in our laboratory. A growing body of evidence suggests that plasticity of the cytoskeleton plays a major role in the biochemical and morphological differentiation of granulosa cells as well as in other steroidogenic cells. © 1994 Wiley-Liss, Inc.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jemt.1070270205
Permalink