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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of angiogenesis on glycated collagen lattices (1998)
    Springer
    Diabetologia 41 (1998), S. 491-499 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Glycation ; endothelial cell ; angiogenesis ; extracellular matrix ; plasminogen activator ; matrix metalloproteinase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Advanced glycation endproduct (AGE) accumulation in extracellular matrix proteins has been demonstrated in diabetic patients with a significant correlation with the severity of diabetic complications. AGE accumulation induces matrix protein cross-link formation, resulting in an increased stiffness of matrix fibres and the reduction of the susceptibility of matrix proteins to proteolytic degradation. We examined whether glycation-induced collagen cross-linking may affect vascular endothelial cell behaviours such as invasion, proliferation and differentiation, using the in vitro angiogenesis model of capillary-like structure formation in three-dimensional matrices of collagen type I. Endothelial cells cultured on collagen gel with angiogenic factors (the combination of fibroblast growth factor-2 and vascular endothelial growth factor) invaded the underlying collagen matrix, and organized capillary-like cord structures in the gel. We found that endothelial cell invasion into glycated collagen gel was significantly attenuated without any effect on proteinase activity including cell-associated plasminogen activator and matrix metalloproteinase in the conditioned medium. In addition, subsequent capillary-like cord formation was also inhibited in glycated collagen gel. In contrast, endothelial cell proliferation was enhanced on glycated collagen gel with or without angiogenic factors compared with control collagen gel. These results suggest that the structural alterations of extracellular matrix proteins through the glycation-induced cross-link formation affect the interaction between endothelial cell and extracellular matrix, resulting in the impairment of an adequate neovascularization in diabetic patients. [Diabetologia (1998) 41: 491–499]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050937
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Phase diagram of the Sb2Se3-CuInSe2 pseudobinary system and flux growth of CuInSe2 single crystals (2000)
    Springer
    Journal of materials science 35 (2000), S. 2553-2556 
    Details
    ISSN: 1573-4803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The phase diagram of the Sb2Se3-CuInSe2 pseudobinary system is constructed by using differential thermal analysis and X-ray diffraction. Based on the constructed phase diagram, solution growth of CuInSe2 crystals is investigated. The grown crystals are evaluated by X-ray diffraction, electron probe microanalysis, Hall effect and inductively coupled plasma measurements. The results indicate that the crystals are not contaminated by the constituent of the flux, i.e., Sb. Hence, Sb2Se3 is promising as a solvent for the growth of CuInSe2 crystals at temperatures lower than 800°C.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004702726256
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    Paper (German National Licenses)
    Fulltext
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