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  • 1
    Electronic Resource
    Electronic Resource
    Increased expression of selectins in kidneys of patients with diabetic nephropathy (1998)
    Springer
    Diabetologia 41 (1998), S. 185-192 
    Details
    ISSN: 1432-0428
    Keywords: Keywords P-selectin ; E-selectin ; diabetic nephropathy ; advanced glycation endproducts ; macrophage.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In diabetic nephropathy leukocytes, mainly composed of monocytes/macrophages, which accumulate in the glomeruli and the interstitium, play an important part in the progression of glomerulosclerosis. The infiltration of leukocytes into inflammatory tissues or atherosclerotic lesions is mediated by adhesion molecules, which are expressed on the vascular endothelial cells, although little is known about the mechanism of leukocyte infiltration into diabetic renal tissues. P- and E-selectin are leukocyte adhesion molecules, which are expressed on the vascular endothelial cells and promote the adhesion of leukocytes to the endothelium. We investigated the expression of P- and E-selectin in the kidney tissue of patients with diabetic nephropathy and compared it with that of patients with other glomerular diseases (minimal change nephrotic syndrome, membranous nephropathy, IgA nephropathy, mesangioproliferative glomerulonephritis, and lupus nephritis). Expression of P- and E-selectin were both significantly increased in the glomeruli and the interstitium of patients with diabetic nephropathy as compared with those with other glomerular diseases. P- and E-selectin were both expressed along the glomerular capillaries and the peritubular capillaries in the interstitium. Neither P- nor E-selectin were correlated with the number of infiltrated leukocytes in the glomeruli, however, interestingly the E-selectin expression on peritubular capillaries was correlated with the number of infiltrated CD14 positive cells in the interstitium. These results suggest that E-selectin may play a key role in leukocyte infiltration into the renal interstitium in patients with diabetic nephropathy. [Diabetologia (1998) 41: 185–192]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050888
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  • 2
    Electronic Resource
    Electronic Resource
    Lafora-like inclusion bodies in the CNS of aged dogs (1978)
    Springer
    Acta neuropathologica 44 (1978), S. 217-222 
    Details
    ISSN: 1432-0533
    Keywords: Lafora-like inclusion bodies ; Aging ; Dog ; High incidence ; Comparative neuropathology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty randomly selected dogs, arranged into three groups according to age, were examined light and electron microscopically. Lafora-like inclusion bodies were found in all cases of aged dogs without neurological signs. They appeared as PAS positive, round bodies measuring up to 15μm in diameter. Typically they had central cores and radiating peripheral lines. Electronmicroscopically, the inclusions consisted of irregularly clustered, short branching filaments measuring about 80–120 Å in diameter or of electrondense homogeneous or granular central cores with filamentous peripheral areas and located both in the perikarya and neuronal processes. The inclusions were disseminated all over the brain and spinal cord. The thalamic nuclei, a circumscribed area dorsal to the aqueduct, and the molecular layer of the superior colliculus were the most severely affected. The frequency of the inclusions showed age-dependency; the inclusions were not found in dogs younger than 2 years, but were extensive in all dogs of more than 8 years of age. The occurrence of the inclusions may therefore represent an age-dependent phenomenon. The relationship between the present findings and Lafora's disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691070
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  • 3
    Electronic Resource
    Electronic Resource
    Isolation of Serratia marcescens mutants which could overproduce and excrete Escherichia coli alkaline phosphatase and beta-lactamase (1994)
    Springer
    Archives of microbiology 161 (1994), S. 414-417 
    Details
    ISSN: 1432-072X
    Keywords: Key words:Serratia marcescens– APase – Overproduction – Beta-lactamase excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract. Serratia marcescens mutants, which excrete Escherichia coli alkaline phosphatase (APase) encoded by the plamid-bearing phoA gene, were isolated after mutagenesis by N-methyl-N′-nitro-N-nitrosoguanidine. These mutants produced two to four times as much APase as did the parent strain under a phosphate-limiting condition, and more than 70% of the enzyme was released into the culture medium. In addition, overproduction and excretion of beta-lactamase was observed in these mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288952
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation of Serratia marcescens mutants which could overproduce and excrete Escherichia coli alkaline phosphatase and beta-lactamase (1994)
    Springer
    Archives of microbiology 161 (1994), S. 414-417 
    Details
    ISSN: 1432-072X
    Keywords: Serratia marcescens ; APase ; Overproduction ; Beta-lactamase excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Serratia marcescens mutants, which excrete Escherichia coli alkaline phosphatase (APase) encoded by the plasmid-bearing phoA gene, were isolated after mutagenesis by N-methyl-Ń-nitro-N-nitrosoguanidine. These mutants produced two to four times as much APase as did the parent strain under a phosphate-limiting condition, and more than 70% of the enzyme was released into the culture medium. In addition, overproduction and excretion of beta-lactamase was observed in these mutants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288952
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  • 5
    Electronic Resource
    Electronic Resource
    Identification of citrulline residues in the V subdomains of keratin K1 derived from the cornified layer of newborn mouse epidermis (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Citrulline residues are detected in keratins and filaggrin in the cornified layers of mammalian epidermis. Such citrulline residues are formed by the enzymatic deimination of arginine residues by peptidylarginine deiminase (EC 3.5.3.15). Major deiminated keratins are thought to be partially degraded/disulfide-cross-linked keratin K1 based on the immunoblotting profiles. In order to obtain more definitive evidence of the deimination of keratin K1 and also to investigate its functional significance, we attempted to identify its preferred acting sites of peptidylarginine deiminase. A partially degraded keratin K1 fraction obtained from the cornified layer of newborn mouse epideermis was subjected to limited proteolytic cleavages, and the resulting deiminated peptides were fractionated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis or reverse-phase high-performance liquid chromatography for N-terminal sequencing and/or amino acid analysis. At least two sites were identified, one in the V1 and the other in the V2 subdomains of keratin K1. An undecapeptide sequence covering the latter shows about 70% homology with an undecapeptide sequence in the V2 subdomain of human K1, a presumptive site of deimination. We speculated that the deimination of arginine residues in these subdomains might modulate their interactions with epidermal proteins other than keratins and filaggrin during the terminal stage of epidermal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00388.x
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  • 6
    Electronic Resource
    Electronic Resource
    Dynamic aspects of protein deimination in developing mouse epidermis (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 8 (1999), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The cornified layer of mammalian epidermis contains deiminated keratins and filaggrin whose arginine residues are partly converted to citrulline residues by peptidylarginine deiminase (EC 3.5.3.15). We have attempted to study dynamic aspects of protein deimination using late embryonic to early postnatal mouse skin. The epidermis was separated from the dermis by brief immersion of skin into a weakly alkaline ammonium chloride solution. The total homogenate of the epidermis was subjected to western blotting analyses for quantitative densitometry of major keratins, deiminated proteins and immunoreactive filaggrin. We found marked increases in both deiminated keratins and deiminated filaggrin from the 18th day of gestation to 2 h after birth followed by rapid decreases to minimum levels at 6 h and subsequent gradual increases sur passing the earlier levels by 72 h after birth. Such variations were associated with consistent changes of the intensity of deiminated proteins stained immunocytochemically. These results suggest that the protein deimination might play a role in dealing with the drastic environmental change after birth. Furthermore, we found compartmentalization of both total and deiminated filaggrins into soluble and particulate fractions. The soluble compartment contained relatively more deiminated filaggrin than the particulate fraction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1999.tb00368.x
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  • 7
    Electronic Resource
    Electronic Resource
    Occurrence of the Y determinant on the N-glycosidic carbohydrate units of human γ-seminoprotein
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 131 (1985), S. 507-514 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(85)91831-5
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  • 8
    Electronic Resource
    Electronic Resource
    High-affinity [^3H]pirenzepine binding to putative M"1 muscarinic sites in the neuroblastoma x glioma hybrid cell line (NG 108-15)
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 119 (1984), S. 289-297 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(84)91650-4
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  • 9
    Electronic Resource
    Electronic Resource
    Development of a compact dilution refrigerator with a cryogenic ^3He J-T circulation system for rapid cooling down and continuous operation
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 165-166 (1990), S. 47-48 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0921-4526(90)80873-H
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Language Sciences 7 (1985), S. 375-377 
    Details
    ISSN: 0388-0001
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Linguistics and Literary Studies
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0388-0001(85)80008-5
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