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  • 1
    Electronic Resource
    Electronic Resource
    Heat(40°C)-induced polypeptides in human embryonic fibroblasts (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 412-413 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The synthesis of 3 polypeptides with molecular weights of 103-, 80- and 78-kdalton (K) was dramatically accelerated when the cultures of human embryonic fibroblasts were transferred from 37 to 40°C. The induction of these polypeptides was not observed if actinomycin D was added to the cultures at the beginning of the rising of the temperature, indicating that this response may be mediated by increased transcription of their messenger RNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963154
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  • 2
    Electronic Resource
    Electronic Resource
    The microvascular architecture of human malignant glioma (1988)
    Springer
    Acta neuropathologica 76 (1988), S. 270-274 
    Details
    ISSN: 1432-0533
    Keywords: Malignant glioma ; Microvascular architecture ; Scanning electron microscope ; Vascular casting
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The three-dimensional microvascular architecture of human glioma was investigated. The results of the study, the first of its kind, suggested that the process of vascularization in glioma is based on two patterns. In a large proportion of the glioma, one pattern is similar to the vascularization observed in normal developing fetal and newborn rat brain, while in a small proportion of the glioma, another pattern including complicated vascular protrusion and spiral running, is seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687774
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  • 3
    Electronic Resource
    Electronic Resource
    Cerebral endothelial regeneration following experimental brain injury (1989)
    Springer
    Acta neuropathologica 77 (1989), S. 397-401 
    Details
    ISSN: 1432-0533
    Keywords: Blood-brain barrier ; Bromodeoxyuridine ; Cerebral endothelium ; Immunohistochemistry ; Regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It is still unknown when and in which area endothelial regeneration occurs after brain injury, and to what extent such changes depend on the severity of the injury. We have, therefore, studied bromodeoxyuridine (BrdU) uptake by regenerating endothelial cells in two different groups of rats given cold lesions using immunohistochemistry employing anti-BrdU monoclonal antibody, anti-factor VIII-related antigen antibody and anti-glial fibrillary acidic protein antibody. The earliest evidence for the presence of BrdU-positive endothelial cells (BrdU+end) was observed at 2 days after injury, the injured endothelial cells regenerating from the edge toward the center of the lesion in both groups. We considered that edema fluid could act as an important factor, since at 2 days post-injury BrdU+end were not in contact with macrophages and were always found in Evans blue-stained areas. Study of endothelial cell kinetics also confirmed that the repair of injured endothelial cells was intimately involved in the reconstruction of the blood-brain barrier, since the time of disappearance of BrdU+end coincided with the disappearance of Evans blue-stained areas. The difference in the process of endothelial regeneration was first apparent on the 3rd day, there being no difference at 2 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687374
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  • 4
    Electronic Resource
    Electronic Resource
    Transferrin receptors in injured brain (1990)
    Springer
    Acta neuropathologica 79 (1990), S. 686-688 
    Details
    ISSN: 1432-0533
    Keywords: Transferrin receptor ; Brain injury ; Edema fluid ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have demonstrated the presence of transferrin receptors (Tf-R) in the central nervous system. The present study of Wistar rats with experimentally induced brain injuries, using immunohistochemistry at the light microscopy level, demonstrated the presence of Tf-R in regenerated endothelial cells, reactive astrocytes and in other cells, probably macrophages. Although Tf-R were seen in proliferating cells, Tf-R were also observed in nonproliferating cells, many of them macrophages. The receptors perhaps bind transferrin in edema fluid and play an important role in lesion repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294248
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  • 5
    Electronic Resource
    Electronic Resource
    Nitrite/nitrate levels in the early phase of acute myocardial infarction (1996)
    Springer
    Intensive care medicine 22 (1996), S. S21 
    Details
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921195
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  • 6
    Electronic Resource
    Electronic Resource
    Subdural Osteoma (1998)
    Springer
    Acta neurochirurgica 140 (1998), S. 727-728 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050171
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  • 7
    Electronic Resource
    Electronic Resource
    Prognostic implications of meningiomas in the elderly (over 70 years old) in the era of magnetic resonance imaging (1994)
    Springer
    Acta neurochirurgica 126 (1994), S. 59-62 
    Details
    ISSN: 0942-0940
    Keywords: Elderly meningioma ; clinical feature ; prognostic implication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During the 5 years from 1987 to 1991, 89 elderly patients, aged 70 years and over, were admitted to departments of neurosurgery in Yamaguchi prefecture with meningioma. The clinical features and prognostic implications of meningioma in the elderly were assessed retrospectively. Seventy-eight (88%) of the 89 patients underwent surgery, which was a higher rate than has been previously reported. The length of clinical history was also shorter than in previous studies, and was partly due to the recent introduction of magnetic resonance imaging (MRI). The incidence of poor prognosis (severe disability, vegetative or dead) in the elderly and a younger group aged less than 70 years was 13% and 7%, respectively, but the difference was not statistically significant. In the surgically treated elderly group, age did not influence the patient's outcome. The factors affecting the outcome were pre-operative neurological deficit (p〈0.05), histological malignancy (p〈0.05), and multiple operations (p〈0.05). Twenty-seven of the elderly meningioma patients were in good physical condition with minimal neurological involvement. They underwent total removal of the tumour at the first operation, and the histological diagnosis was benign. Twenty-five of these 27 patients fell into the best outcome category. Therefore, age alone was not a factor preventing proper surgical treatment of meningioma in the elderly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476411
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of intravenous nitroglycerin combined with dopamine on intracranial pressure and cerebral arteriovenous oxygen difference in patients with acute subarachnoid haemorrhage (1995)
    Springer
    Acta neurochirurgica 136 (1995), S. 175-180 
    Details
    ISSN: 0942-0940
    Keywords: Nitroglycerin ; intracranial pressure ; cerebral arteriovenous oxygen difference ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of intravenous nitroglycerin (NTG) combined with dopamine on intracranial pressure (ICP) and cerebral arteriovenous oxygen difference (AVDO2) were studied in 11 patients with acute subarachnoid haemorrhage (SAH). The study was performed on Days 1 to 3 of SAH after aneurysmal clipping. Treatment consisted of an intravenous drip infusion of NTG in increasing incremental doses of 0.5, 1.0, 1.5, 2.0, and 2.5 μg/kg/min at one-hour intervals. Dopamine (5 to 10 μg/kg/min) was also given concurrently to maintain systemic blood pressure. ICP values before NTG administration ranged from 7 to 24 mmHg (mean, 11.91±5.30 mmHg). ICP began to increase immediately after the adminisration of NTG 0.5 μg/kg/min and peaked at 14.64±5.93 mmHg 10 minutes after onset of infusion. Thereafter, ICP gradually returned to pretreatment levels. Increasing the dose of NTG failed to induce further significant rises in ICP. Mean AVDO2 before NTG administration was 4.69±0.62 ml/dl. This parameter showed no significant change during NTG infusion, although cerebral perfusion pressure decreased to between 75% to 94% of the control value after NTG administration. These results indicate that continuous NTG infusion combined with dopamine does not have adverse effects on ICP (the ICP increase is minimal and transient) and may even have beneficial effects on CBF in patients with acute SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410622
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  • 9
    Electronic Resource
    Electronic Resource
    Emulsion Stabilizing Properties of Soy Protein Isolates Mixed with Sodium Caseinates (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 49 (1984), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: To most effectively utilize the valuable functional properties of soy protein isolates (SPI), it is necessary to study their functional behavior in complex systems where interaction with other components (e.g., proteins, fats, carbohydrates, etc.) is expected to occur. The effect of mixing SPI and sodium caseinates (SC) on SPI emulsion stabilizing properties (ESP) was evaluated by determining emulsion stability, % adsorption of proteins onto the oil globule surface and SDS-polyacrylamide gel electrophoretic analysis. In emulsions prepared using the shearing force method, the high ESP (77%) of SPI was decreased to a low level (15%)–the same as that for SC–by mixing SC with the SPI. The main reason for this phenomenon is the initial coating of the oil globules with a thin layer of SC which prevents adsorption of SPI.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1984.tb13710.x
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of Lipophilization of Soy Protein on Its Emulsion Stabilizing Properties (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 46 (1981), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Effect of lipophilization of the soy protein (SP) molecule on emulsion stabilizing properties (ES) was investigated by comparing the properties of alcohol-modified, acetylated, partially hydrolyzed and unmodified SP. The modified SPs showed high ES even in the slightly acidic region, where the protein solubility remained at low level, whereas the ES of unmodified SP decreased with the decrease of protein solubility. The hydrophile-lipophile balance (HLB) number of SP at pH 4.5 decreased and its ES increased as a result of modifications. Both the exposed tyrosine of SP determined by ultraviolet difference spectra and the hydrophobic region on the surface of the SP molecule compared with relative fluorescent intensity was increased by ethanol-modification. The ES of the modified SP were found to increase almost linearly with the increase in fluorescent intensity and intrinsic viscosity. Considering these facts and the nature of effect of alcohols on globular proteins, it was concluded that lipophilization of the SP molecule is one of the primary factors which increase the ES in the slightly acidic region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1981.tb03021.x
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