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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 1132-1135 
    ISSN: 1432-1440
    Keywords: Phase imaging ; Radionuclide ventriculography ; Ventricular pacing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phase imaging of gated radionuclide ventriculography was applied to the identification of cardiac activation patterns in patients with sinus rhythm (n=14) or with ventricular (VVI)- (n=28), atrial (AAI)- (n=3) or AV-sequential (DDD)-pacing (n=17). In patients with sinus rhythm, AAI-or DDD-pacing, analysis revealed homogeneous distribution of phase across both ventricles. In VVI-pacing a left bundle branch block configuration of the ventricular activation was found in 21 of 28 patients. In 7 of 28 patients phase distribution indicated a simultaneous activation of both ventricles (with or without delimitation of the apex of the right ventricle). This is of clinical importance because artificial spread of excitation and asynchronous contraction during VVI-pacing may be responsible for higher myocardial oxygen demand. Retrograde conduction in VVI-pacing was found in 9 of 28 patients. Phase analysis provides a reliable method for evaluation of pacing-induced activation patterns.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 55 (1977), S. 711-712 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 965-966 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1440
    Keywords: Cis-dichlorodiammine-platinum (II) ; Nephrotoxicity ; Iodo-131-hippurate-clearance ; Serum creatinine ; Creatinine clearance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatininc to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearence nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 477-478 
    ISSN: 1432-1440
    Keywords: Autonomous thyroid nodules ; Oral TRH test ; Results ; Autonomes Adenom ; Oraler TRH-Test ; Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 17 Patienten mit kompensierten autonomen Adenomen der Schilddrüse wurden TRH-Teste mit 200 µg i.v. und 40 mg oral durchgeführt. Bei 9 Patienten war TSH 30 min nach TRH i.v. normal (〉2.7 µU/ml), dagegen zeigten 8 Patienten einen subnormalen (〈2.7 µU/ml) oder fehlenden TSH-Anstieg. Nach verlängerter Stimulation mit 40 mg TRH oral war TSH 120–180 min bei 15 Patienten im Normbereich (〉2.7 µU/ml) und nur bei 2 Patienten subnormal (〈2.7 µU/ml). Bei 20 Patienten mit dekompensierten autonomen Adenomen der Schilddrüse lag TSH sowohl nach i.v. als auch nach oraler TRH-Stimulation in allen Fällen unter der Nachweisgrenze (〈0.8 µU/ml). Die Befunde sprechen dafür, daß der orale TRH-Test geeigneter ist als der i.v. TRH-Test, um zwischen kompensierten und dekompensierten autonomen Adenomen der Schilddrüse zu unter-scheiden.
    Notes: Summary In 17 patients with compensated autonomous adenomas of the thyroid, iv thyrotropin releasing hormone (TRH) tests (200 µg) and oral TRH tests (40 mg) were performed. In nine of these patients, thyroid-stimulating hormone (TSH) 30 min after iv TRH showed a normal (〉2.7 µU/ml) and in eight patients a subnormal (〈2.7 µU/ml) or negative response. However, after prolonged oral stimulation with 40 mg TRH, after 120–180 min TSH was normal (〉2.7 µU/ml) in 15 and subnormal (〈2.7 µU/ml) in two patients. In 20 patients with decompensated autonomous thyroid nodules, TSH was not detectable (〈0.8 µU/ml) after iv or oral TRH stimulation. Therefore, the oral TRH stimulation test seemed to be superior to the iv TRH test in the discrimination of compensated and decompensated autonomous adenomas of the thyroid.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 210 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 354 (1981), S. 73-79 
    ISSN: 1435-2451
    Keywords: Ultrasonographic follow-up examination ; Renal transplantation ; Nuclear procedures ; Local complications after renal transplantation ; Rejection reaction of renal transplant
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird berichtet über sonographische Routinekontrollen nach Nierentransplantation bei 72 Patienten. Die Kontrollen sollten in erster Linielokale Komplikationen im Operationsgebiet erfassen und diese gegebenenfalls von einer Abstoßungsreaktion bei nicht eindeutigen klinischen Befunden abgrenzen. Bei den 72 Patienten wurden insgesamt 295 Sonographien durchgeführt. Es fanden sich 22 lokale Komplikationen, von denen 15 im klinisch noch stummen Stadium sonographisch erfaßt wurden. Diese Patienten konnten dann frühzeitig einer chirurgischen bzw. urologischen Behandlung zugeführt werden. Aufgrund dieser Ergebnisse erscheint uns die routinemäßige sonographische Kontrolle des Nierentransplantates zur frühzeitigen Erfassung einer lokalen Komplikation im OP-Gebiet gerechtfertigt, während nuclearmedizinische Methoden bei der Frage nach vasculären Veränderungen und bei gestörter Transplantatfunktion eingesetzt werden sollten.
    Notes: Summary Routine follow-up examinations by ultrasonography after renal transplantation were performed in 72 patients from December 1978 until March 1980. The aim of these controls was to recognizelocal complications in the area of surgery in order to differentiate from a rejection reaction in patients with unclear clinical symptoms. 22 out of 72 patients had local complications. 15 out of those 22 were detected by ultrasound in a state without clinical symptoms, which then could be treated by surgical or urological intervention. We therefore believe that routine follow-up examinations after renal transplantation by ultrasound are indicated in order to recognize local complications. Nuclear procedures should be employed if alteration of blood flow or disturbed function of the transplanted kidney are considered.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 1 (1976), S. 125-136 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the validity of the quantitative 201Tl scintimetry in various diseases of the heart (coronary heart disease with and without myocardial infarction, non-coronary cardiomyopathy, scleroderma heart disease and asymmetric septal hypertrophy with IHSS), the 201Tl myocardial uptake values for five standardized projections (a) were correlated with the grade of LAD stenosis, (b) the pattern of myocardial wall motion and (c) were compared with the 201Tl uptake values derived from normal patients. Significant reduction (c) of 201Tl myocardial uptake could in individual cases be evaluated in acute myocardial infarction (95%), in dys-and akinesia (90%), in hypokinesia (71%), in scleroderma heart disease (50%), in non-coronary cardiomyopathy (50%) as well as in normokinesia (28%) when associated with LAD stenosis. The mean values (b) of 201Tl uptake in normo-and hypokinesia significantly differed between these two groups and from those evaluated in dys-and akinesia. The latter group showed the lowest 201Tl uptake values computed which in some cases were very close to the mean mediastinal 201Tl uptake. The correlation (a) of individual 201Tl values demonstrated that 201Tl distribution in the myocardium is not only equivalent to myocardial “perfusion” but is corresponding with the myocardial function. In non-coronary cardiomyopathy reduced 201Tl values sometimes could not be separated from values in coronary heart disease (and myocardial infarction). A regional increase of myocardial mass as in septal hypertrophy correlated well with an augmented 201Tl uptake when referred to the 201Tl storage in the mediastinum.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 19 (1992), S. 826-826 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 24 (1997), S. 348-349 
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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