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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 67 (1989), S. 640-644 
    ISSN: 1432-1440
    Keywords: Ectopic ACTH syndrome ; Ovarian carcinoid ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 56-year old woman with severe Cushing's syndrome due to ovarian ACTH-production is described. Both clinical picture and biochemical pattern were consistent with the ectopic ACTH syndrome. ACTH was found by specific immunohistochemical staining in a carcinoid tumor of the patient's right ovary. In contrast, pituitary cells exhibited immunoreactive ACTH to only a minimum extent.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Knee surgery, sports traumatology, arthroscopy 4 (1996), S. 190-190 
    ISSN: 1433-7347
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Sports Science
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2307
    Keywords: Glioma antigens ; Epidermal growth factor receptor ; Nerve growth factor receptor ; Transferrin receptor ; Chromosomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The human glioblastoma-derived cell lines 86HG-39, 87HG-28 and 87HG-31, used for the production of monoclonal antibodies (mAbs) against glioma-associated antigens (GAA), were characterized in terms of morphology, growth behaviour, chromosomes and antigen expression. In the primary tumours, differential expression of glial fibrillary acidic protein, S100 protein, Leu-7 and GAA as defined by mAbs MUC 2–39, MUC 2–63 and MUC 8–22 was demonstrated. Receptors for epidermal growth factor (EGFr) and nerve growth factor (NGFr) were found in many cells in short-term cultures, but the transferrin receptor (Tr) was found in only a few cells of 87HG-28. In permanent cell lines, differentiation antigens and EGFr decreased and Tr increased markedly. NGFr and GAA remained stable. Transplantation tumours of 86HG-39 were partly positive for Tr and GAA. Chromosomal analysis revealed that the 86HG-39 and 87HG-28 cell lines had a hypodiploid or diploid stem line with lines in the hypotetraploid to tetraploid region for 50 in vitro passages. The 87HG-31 cell line had chromosomal patterns in the hypotriploid to triploid region. A gain of chromosomes was seen in the groups C7, C8, C10, D14, F19, F20, G21, G22. The variability of antigens in these tumours and especially during long-term cultivation probably reveals an ability to influence the growth of malignant glioma cells via the respeective effector molecules.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Localized fibrous tumour of the pleura ; Benign mesothelioma ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five localized fibrous tumours of the pleura (benign mesothelioma) were studied ultrastructurally in order to elucidate their histogenesis. The histological subtypes of this benign fibrous lesion of the visceral pleura, i.e. the cellular, the collagenous, and the hyaline, were separately analysed. The tumours are composed of undifferentiated mesenchymal cells, intermediate and differentiated fibroblasts as well as collagenous interstitial tissue. The varying distribution of these cell elements account for the various histological subtypes. Morphological similarities between the mesenchymal tumour cells and the superficial mesothelial cells, which are always separated from the true tumour tissue by an intact basement membrane, were not observed. The different cellular elements can be regarded as parts of a continuous spectrum of cytodifferentiation, in which the mature fibroblasts are derived via intermediate forms from the undifferentiated cells. It is concluded that the localized fibrous tumours of the pleura arise from immature mesenchymal stem cells, which seems to be normally found in the submesothelial layer of the visceral pleura.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1238
    Keywords: Acute respiratory failure ; Anticoagulation ; Artificial lung ; Extracorporeal gas exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Treatment of severe acute respiratory failure with extracorporeal gas exchange necessitating near complete systemic anticoagulation requires a delicate balance to be maintained between disseminated intravascular coagulation and hemorrhagic complications. The present study describes our first experience using a heparin coated extracorporeal artificial lung and circuitry during clinical extracorporeal CO2 removal. In spite of a partial thromboplastin time and activated clotting time within or close to the normal range, neither laboratory evidence for disseminated intravascular coagulation induced by the extracorporeal circuit nor thrombi in the pulmonary vasculature were found. Scanning electron microscopy of the heparin coated hollow fiber gas exchanger demonstrated only minor deposits on the surface. Use of a heparin coated artificial lung may enhance the margin of safety of extracorporeal gas exchange and ultimately broaden its indications.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 113 (1987), S. 279-284 
    ISSN: 1432-1335
    Keywords: Computed tomography ; Liver ; Pancreas ; Adrenals ; Lymph nodes ; Autopsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The value of abdominal computed tomography (CT) in diagnosing localized involvement of liver, pancreas, adrenals, and lymph nodes was evaluated in 117 patients with suspected or known malignant tumors by correlation with autopsy findings. Sensitivity, specificity, and accuracy of CT for localized liver disease was calculated to be 80% (84%), 96% (97%), and 90% (92%); for pancreatic tumors: 81% (86%), 98% (100%), and 95% (97%); for adrenal tumors: 65% (92%), 100% (100%), and 92% (98%); and for lymph node enlargement 75 (88%), 97% (98%), and 87% (94%), respectively. Results of routine evaluation could be improved, especially in the adrenal region, when scans were reevaluated by highly experienced examiners (results given in parenthesis). Computed tomography is a highly valuable diagnostic tool in the primary diagnosis and in the follow-up of tumor patients. The high costs are offset by a reduction in invasive procedures and a shortened hospital stay.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 16 (1995), S. 336-341 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Halsarterien ; Kranzarterien ; Aorta ; Endarterektomie ; Desobliteration ; Arteriosklerose ; Key words Cervical arteries ; Coronary arteries ; Aorta ; Endarterectomy ; Recanalisation ; Arteriosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Recanalisation of the carotid sinus is one of the most frequently performed vascular interventions; endarterectomy of the coronary arteries is an auxiliary measure accompanying aortocoronary bypass. Enucleation of the sclerotic plaque is followed by reconstruction of the intima and by rapid smoothing over of the “steps” along the side of the recanalised segment by proliferation of smooth muscle cells from the remaining media. The thinner the residual media, the thicker grows the neointima. Occasionally elastic lamellae reminiscent of a lamina elastica interna are formed close to the lumen. Moreover, in some cases renewed formation of the characteristic intimal spur (fibrotic ridge) is seen at the carotid sinus inlet, a sign of continued irregularity of blood flow postoperatively. In contrast, no focal lesions are generally observed in recanalised segments in the coronary arteries. New sclerotic pads that occur in the late phase bear a morphological resemblance to those in operated restenoses. The distribution of these pads is largely congruent with that of the sclerotic plaques in non-operated cervical arteries. Thus, even when recanalisation of the carotid sinus is uncomplicated, reparative processes are followed by the re-formation of sclerotic pads, largely determined by haemodynamic factors. In the coronary arteries, concentric rather than focal sclerotic lesions predominate.
    Notes: Zusammenfassung Die Desobliteration des Karotissinus ist eine der häufigsten Gefäßoperationen, die Endarterektomie der Kranzarterien gilt als ergänzende Methode beim aortokoronaren Bypass. Nach Ausschälung der sklerotischen Plaques erfolgt die Rekonstruktion einer Intima und die Glättung der randlichen Stufen des Desobliterationsbettes rasch durch eine Proliferation glatter Muskelzellen aus den verbliebenen Mediaanteilen. Dabei erreicht diese sog. Neointima eine umso größere Breite, je schmaler der verbliebene Mediaanteil gewesen ist. Gelegentlich kommt es auch zur Ausbildung lumennaher elastischer Lamellen, die einer Lamina elastica interna ähnlich sind. Ferner kann teilweise der Wiederaufbau des für die Karotisbifurkation charakteristischen Intimasporns (fibröse Leiste) am Eingang zum Sinus caroticus beobachtet werden, der ein Indiz für offenbar auch postoperativ anhaltende Strömungsunregelmäßigkeiten an dieser Stelle ist. Im Gegensatz dazu lassen sich in den Kranzarterien im Bereich des Desobliterationsbettes in der Regel keine derartigen herdförmigen Veränderungen beobachten. Neue sklerotische Polster, die in der Spätphase auftreten, gleichen morphologisch denen in operierten Restenosen. Die Verteilung derartiger Polster ist dem Muster der sklerotischen Plaques in nicht operierten Halsarterien weitgehend kongruent. Im Anschluß an eine Desobliteration im Karotissinus wiederholt sich hier somit auch bei komplikationslosem Verlauf nach reparativen Prozessen der Werdegang sklerotischer Polster, der hier wesentlich durch hämodynamische Faktoren bestimmt wird. In den Kranzarterien überwiegen konzentrische und nicht herdförmige betonte sklerotische Wandveränderungen das Bild.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 15 (1994), S. 54-57 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter: Leber – Gallengänge – Rhabdomyosarkom – Kindesalter – Erwachsenenalter ; Key words: Liver – Rhabdomyosarcoma – Adult – Childhood – Large bile ducts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract. Primary sarcomas of the liver are rare, and hepatic rhabdomyosarcomas are usually confined to early childhood. They are mostly related to large bile ducts of the liver hilus. We report a case of primary hepatic pleomorphic rhabdomyosarcoma in a 69-year-old man.
    Notes: Zusammenfassung. Primäre Sarkome der Leber sind selten. Rhabdomyosarkome in der Leber treten in der Regel im frühen Kindesalter auf. Sie nehmen ihren Ausgang fast immer von den großen Gallengängen im Leberhilus. In dieser Kasuistik wird über ein pleomorphes Rhabdomyosarkom der Leber bei einem 69 Jahre alten Mann berichtet.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Pathologe 20 (1999), S. 359-364 
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Leber ; Osteosarkom ; Histogenese ; Key words Liver ; Osteosarcoma ; Histogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Primary sarcomas of the liver are rare. Most of them are angiosarcomas often related to exposure to thorotrast or polyvinyl chloride. We report a case of primary osteosarcoma of the liver in a 72-year-old man and compare it with the seven cases from the literature
    Notes: Zusammenfassung Primäre Sarkome der Leber sind selten, wobei am häufigsten Angiosarkome nach Thorotrast- oder Polyvinylchloridexposition beschrieben werden. In dieser Kasuistik wird über ein primäres Osteosarkom der Leber bei einem 72jährigen Mann berichtet und dieser Fall mit den 7 bisher in der Literatur mitgeteilten Beobachtungen verglichen.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Archives of orthopaedic and trauma surgery 111 (1992), S. 273-279 
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A multiplicity of surgical operations have been developed in an attempt to achieve satisfactory function after anterior cruciate ligament (ACL) repair. None of these procedures have been able to reproduce the fiber organization anatomy of attachment site, vascularity, or function of the ACL. Twenty-nine foxhounds received a deep-frozen bone-ACL-bone allograft and a ligament augmentation device (LAD). Biomechanical, microvascular, and histological changes were evaluated 3, 6, and 12 months following implantation. The maximum loads of the allograft/LADs were 34.3% (387.2N) after 3 months, 49.3% (556.6N) after 6 months, and 61.1% (698.8N) after a year. The maximum load was 69.1% (780 N). In general, after 6 months the allografts showed normal collagen orientation. The allografts demonstrated no evidence of infection or immune reaction. No bone ingrowth into the LAD was observed. Polarized light microscopy and periodic acid-schiff staining showed that the new bone-ligament substance interface had intact fiber orientation at the area of the ligament insertion. Microvascular examination using the Spalteholtz technique revealed revascularization and the importance of an infrapatellar fat pad for the nourishment of ACL allografts.
    Type of Medium: Electronic Resource
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