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  • 1
    Electronic Resource
    Electronic Resource
    Intragastric and intraoesophagel pH monitoring in duodenal ulcer patients: effect of the new histamine H2-receptor antagonist ramixotidine (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: ramixotidine ; oesophagitis ; duodenal ulcer ; gastro-oesophageal reflux ; histamine H2-antagonist ; intragastric pH monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of the new histamine H2-receptor antagonist ramixotidine 750 mg p.o., administered at 22.00 h, on intragastric and intraoesophageal pH monitored from 22.00 h to 08.00 h, was studied in a double-blind cross-over trial in 11 duodenal ulcer patients. Placebo and ramixotidine were given to each patient on 2 consecutive days in a randomized sequence. Three patients were excluded from the intragastric pH analysis as the records on the second study day were technically inadequate. No significant carry-over or sequence effect was noted. Intragastric hydrogen ion activity was significantly lower (p=0.01) after ramixotidine than after placebo: median (range) 24 (9–100) vs 97 (27–188) mmol/l. The percentage of time with intraoesophageal pH 〈4 was less than 5% in all but three recordings, with a maximum value of 12%, and it was not significantly different after the two treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558510
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  • 2
    Electronic Resource
    Electronic Resource
    Infra-Red Spectra of Deoxyribonucleic Acids from Human Leucocytes (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 964-965 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A Perkin-Elmer, model 21, double-beam spectrometer with sodium chloride and calcium fluoride optics has been used. With slit-widths narrower than those used by Blout and Lenormant4 and with suitable adjustments, we were able to improve the resolution. The deuterium solutions were prepared in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/186964a0
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  • 3
    Electronic Resource
    Electronic Resource
    HBV, HDV and HIV infections in 242 drug addicts: Two-year follow-up (1988)
    Springer
    European journal of epidemiology 4 (1988), S. 318-321 
    Details
    ISSN: 1573-7284
    Keywords: Hepatitis B ; Hepatitis delta ; Human immunodeficiency virus ; Drug addicts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Of 242 north Italian heroin addicts, 24 (9.9%) were HBsAg positive. HBeAg was positive in two of them (8.3%), anti-HBe in 16 (66.6%) and anti-HDV in 21 (87.5%). Of the 218 HBsAg negative, 182 (83.5%) had anti-HBc, 72 (33.0%) anti-HBe and 97 (44.5%) anti-HBs. One-hundred-eighty-five drug addicts were anti-HIV positive (76.4%); 77 of these (41.6%) were asymptomatic, 93 (50.3%) had PGL and 15 (8.1%) ARC. T4+ cell count was significantly lower in subjects with ARC as was T4+/T8+ ratio in subjects with PGL and ARC. During a median follow-up of 9.5 months (range 4–25), we observed three new cases of hepatitis (two caused by NANBV and one by HBV with HDV coinfection) and one new HIV infection. Ten anti-HIV positive subjects developed PGL and one AIDS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00148917
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of cold stress on postprandial lower esophageal sphincter competence and gastroesophageal reflux in healthy subjects (1992)
    Springer
    Digestive diseases and sciences 37 (1992), S. 1200-1205 
    Details
    ISSN: 1573-2568
    Keywords: esophageal function ; esophagus ; gastroesophageal reflux ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of cold stress on postprandial lower esophageal sphincter competence and gastroesophageal reflux was investigated in nine healthy subjects. All subjects were studied twice in a randomized order according to a common protocol: 30 min after completion of a 700-kcal meal they put their nondominant hand in water either at 37°C (control stimulus) or at 4°C (stressful stimulus) cyclically for 20 min. Pulse rate and blood pressure rose significantly (P〈0.01) during the stressful stimulus, but remained unaffected by the control stimulus. Rate of transient lower esophageal sphincter relaxations/30 min [median (interquartile range)] was similar before and during control stimulus, 4 (2.7–5.0) and 3 (2.0–4.5), respectively, whereas it was markedly inhibited during the stressful stimulus [from 5 (3.7–6.0) to 2 (1.0–2.0);P〈0.05 vs control stimulus]. Rate of reflux episodes/30 min was also similar before and during control stimulus, 1 (0–1.2) and 1 (1.0–2.2), but fell consistently during the stressful stimulus [from 2 (0–3.2) to 1 (0–2.0);P〈0.05 vs control stimulus]. Percentage of transient lower esophageal sphincter relaxations accompanied by a reflux episode was unaffected by stress as was basal lower esophageal sphincter pressure. It is concluded that cold stress decreases the postprandial rate of transient lower esophageal sphincter relaxations and reflux episodes in healthy humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296560
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  • 5
    Electronic Resource
    Electronic Resource
    Intraesophageal pH Monitoring During Acid Infusion in Patients with Systemic Sclerosis (1999)
    Springer
    Digestive diseases and sciences 44 (1999), S. 1716-1720 
    Details
    ISSN: 1573-2568
    Keywords: SYSTEMIC SCLEROSIS ; ESOPHAGEAL PH ; ESOPHAGEAL MOTILITY ; ESOPHAGEAL CLEARANCE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Incidental clinical observations suggest thatbuffering substances may accumulate in the distalesophagus of patients with systemic sclerosis. The aimof our study was to assess if the buffering capacity of the intraesophageal milieu is increased inpatients with systemic sclerosis and if this effect canbe correlated to some pathophysiological aspects of thedisease. We recorded intraesophageal pH before and during a 10-min intraesophageal infusion ofacid (HCl 0.01 N, 1 ml/min), as well as esophagealmotility and clearance function, in 16 patients withsystemic sclerosis and 10 healthy subjects. Esophageal buffering capacity expressed as the area underthe curve of intraesophageal pH during acid infusion wassignificantly higher in the patients than in thecontrols, and this variable was directly correlated with esophageal clearing time. In conclusion,esophageal buffering capacity is increased in patientswith systemic sclerosis and is possibly the consequenceof the accumulation of buffering substances in the distal esophagus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026656220075
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  • 6
    Electronic Resource
    Electronic Resource
    Prevalence of HIV infection in 646 heroin addicts and outcome of HIV-related conditions in the 266 followed up (1991)
    Springer
    European journal of epidemiology 7 (1991), S. 83-87 
    Details
    ISSN: 1573-7284
    Keywords: HIV ; Hepatitis B ; Hepatitis delta ; Heroin users ; AIDS-related complex (ARC) ; AIDS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a series of 646 heroin addicts anti-HIV was detected in 428 (66.2%) and HBsAg in 53 (8.2%). Forty-eight (90.5%) of the latter had concomitant chronic HDV infection. Markers of past HBV infection were found in 481 (74.4%). The prevalence of anti-HIV was significantly higher in the 534 subjects with HBV markers than in the other 112 without markers (69.8% versus 49.1%, p 〈 0.001). Of the 266 anti-HIV positive subjects followed for 3–48 months (median 12), nine progressed from no disease to persistent generalized lymphadenopathy (PGL), 52 from PGL to AIDS-related complex (ARC) or AIDS (30 and 22 cases respectively), and six from ARC to AIDS. Baseline T4 + cell count was significantly lower and reduction during follow-up significantly greater in heroin addicts with disease progression than in those without.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221346
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  • 7
    Electronic Resource
    Electronic Resource
    Orocecal transit delay in obese patients (1989)
    Springer
    Digestive diseases and sciences 34 (1989), S. 509-512 
    Details
    ISSN: 1573-2568
    Keywords: opioids ; naloxone ; gastrointestinal motility ; breath test ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Orocecal transit time was assessed with lactulose hydrogen breath test in 12 obese patients during intravenous infusion of placebo or naloxone 40 μg/kg/hr given in randomized order and in double-blind conditions. Transit time was also evaluated in 22 healthy controls. Orocecal transit was significantly (P〈0.01) longer in the obese patients during placebo treatment (median 130, range 100–200 min) than in the healthy controls (median 75, range 40–170 min). Compared with placebo, transit time in the obese subjects was delayed (P〈0.05) during naloxone treatment (median 150, range 100–230 min).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01536325
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  • 8
    Electronic Resource
    Electronic Resource
    Repeatability of lactulose hydrogen breath test in subjects with normal or prolonged orocecal transit (1988)
    Springer
    Digestive diseases and sciences 33 (1988), S. 1525-1527 
    Details
    ISSN: 1573-2568
    Keywords: breath test ; gastrointestinal motility ; constipation ; obesity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The within-subject repeatability of orocecal transit assessed with lactulose hydrogen breath test was evaluated in 15 healthy volunteers and 16 constipated or obese patients. The test was repeated twice in each subject. Mean (sd) transit time was 105 (63) and 103 (60) min in the first and second series of tests, respectively, showing that the first measurement did not affect the second. The within-subject repeatability of the test was related to the length of transit, the scatter of the differences between the first and second test being greater with the increase of the mean gastrointestinal transit time. The 95% coefficient of repeatability was 84 min for all measurements and 30 and 118 min, respectively, for transit times under and over 100 min. The lowest reproducibility of the test was found in constipated patients with prolonged orocecal transit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01535941
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  • 9
    Electronic Resource
    Electronic Resource
    Lactose malabsorption and intolerance in Italians (1986)
    Springer
    Digestive diseases and sciences 31 (1986), S. 1313-1316 
    Details
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lactose malabsorption was assessed by the hydrogen breath test in 40 Italian patients with irritable bowel syndrome and 42 controls without abdominal disturbances. Sixty-five percent of patients were “low milk consumers” (0–250 ml milk per day) compared with 38% of controls (P〈0.02). Lactose loads of 25 and 50 g caused malabsorption in 82.5 and 87.5% patients and in 55 and 62% controls, respectively (patients vs controlsP〈0.02). Malabsorption was more frequent in the “low milk consumers” group (P〈0.05). During a four-month lactose-free diet as the only treatment 7.5% of patients became symptomfree (and remained so for a further eight-month diet), 52.5% improved, and 40% showed no change.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01299809
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  • 10
    Electronic Resource
    Electronic Resource
    Oral naloxone antagonizes loperamide-induced delay of orocecal transit (1987)
    Springer
    Digestive diseases and sciences 32 (1987), S. 829-832 
    Details
    ISSN: 1573-2568
    Keywords: naloxone ; loperamide ; orocecal transit ; hydrogen breath test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Orocecal transit time was determined by the lactulose hydrogen breath test in nine healthy volunteers after administration of placebo, loperamide (16 mgper os), and loperamide (16 mgper os) followed by oral naloxone at doses of 16 and 32 mg. The four tests were performed in double-blind conditions and in random sequences. Transit time (mean,sd) after loperamide (128.8 min, 32.9) was significantly increased (P〈0.05) compared with placebo (85.5 min, 35.7), loperamide followed by naloxone 16 mg (88.8 min, 46.2), and loperamide followed by naloxone 32 mg (84.4 min, 40.6). These results show that the peripheral opioid agonist loperamide delays orocecal transit in healthy subjects and that naloxoneper os at adequate doses antagonizes this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01296704
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