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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1230-1231 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Unlike the previously reported inhibitory effect of histamine on the production of the lymphokine, migration inhibitory factor, histamine did not inhibit the production of macrophage aggregating factor (MAgF). By contrast, both prostaglandin E2 and hydrocortisone inhibited MAgF production, in a dose-dependant manner.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 13 (1983), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A study was made to establish the value of the leucocyte aggregation test (LAT) in drug allergy using penicillin antigen. The antigen-induced human peripheral blood leucocyte aggregation was measured quantitatively. The results obtained have been compared with the leucocyte migration inhibition test (LMIT) in patients with or without delayed penicillin allergy. Among forty-four penicillin-allergic subjects and thirty-six control subjects, LAT was found positive in respectively 70.5 and 30.5% (P 〈 0.001) whereas LMIT was found positive in respectively 56.8 and 50% of the patients. These results were confirmed by multiple correspondence analysis (MCA), using a computer. Furthermore, this method, enables a more comprehensive and reliable interpretation of the tests, by the help of various quantitative and qualitative criteria.It is concluded that LAT shows more discrimination than the LMIT in distinguishing a penicillin-allergic population from a non-allergic one. In addition, LAT offers great technical advantages over the LMIT for the diagnosis of drug allergy.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    International Journal of Biochemistry 6 (1975), S. 387-388+IN1-IN2+389-392 
    ISSN: 0020-711X
    Keywords: Urate ; chick ; isolated cell ; liver ; purine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    FEBS Letters 43 (1974), S. 227-230 
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 11 (1981), S. 622-624 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human lymphokine (LK) is known to induce guinea-pig macrophage aggregation. This effect can be quantitiatively measured with a Born modified platelet aggregometer. This method has been well correlated with the state of delayed hypertensitivity. Previous findings about the mechanism of action of the aggregation indicated that this aggregation is not due to an increase in the cellular level of c-AMP. It is doubtful whether c-AMP is a messenger of the LK action. Using a radio-immunoassay, small but significant increases were found in c-GMP levels of LK-aggregated macrophages. In addition, exogenous dibutyryl c-GMP and carbamylcholine induced a macrophage aggregation, as did the divalent cation ionophore A-23187. These data, together with the fact that LK-induced macrophage aggregation is inhibited by colchicine and at 0°C, suggest that microtubule polymerization is involved in this process.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 42 (1986), S. 433-435 
    ISSN: 1420-9071
    Keywords: Plasminogen activator ; NaCl ; metastasis ; MAT 13762 cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Plasminogen activator, secreted by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl. Intact cells, however, expressed strong activity under similar conditions. Thus, if plasminogen activator is involved in invasion and metastasis, the cellular activity, acting as an ectoenzyme, may be more important than secreted enzyme under physiological conditions.
    Type of Medium: Electronic Resource
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