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  • 1
    Electronic Resource
    Electronic Resource
    Differentiation of lymphocytes in cerebrospinal fluid in disorders of the central nervous system (1977)
    Springer
    Journal of molecular medicine 55 (1977), S. 903-906 
    Details
    ISSN: 1432-1440
    Keywords: Lymphozyten ; Liquor ; Immunglobuline ; Lymphocytes ; Cerebrospinal fluid ; CNS-disorders ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 73 patients with variable CNS-disorders Slg-lymphocytes and RF-lymphocytes originating from CF were characterized by demonstration of surface markers. In the CF the Slg-lymphocytes were increased in comparison to the blood whereas the RF-lymphocytes generelly were decreased. Patients suffering from acute or chronic inflammatory diseases had significantly more Slg-lymphocytes while RF-lymphocytes were significantly decreased in those patients as well as in patients with malignancies. A correlation between the number of Slg-lymphocytes and immunoglobulin-levels was not seen. The respective data in blood did not follow the changes in CF. The results suggest a prevailing stimulation of the humoral immune system of the CNS during inflammatory diseases.
    Notes: Zusammenfassung Bei 73 Patienten mit ZNS-Erkrankungen wurden im Liquor SIg-Lymphozyten und RF-Lymphozyten durch Nachweis von Oberflächenmarkern charakterisiert. Im Vergleich zu den Werten im Blut waren generell die SIg-Lymphozyten vermehrt, wogegen die RF-Lymphozyten vermindert waren. Darüber hinaus hatten Patienten mit akuten und chronischen Entzündungsprozessen vermehrt SIg-Lymphozyten. RF-Lymphozyten waren außer bei diesen Erkrankungen auch bei Malignomen erniedrigt. Ein Zusammenhang zwischen den Immunglobulinspiegeln und dem Gehalt an SIg-Lymphozyten im Liquor war nicht nachweisbar. Die erwähnten Verschiebungen lassen sich im Blut nicht nachweisen. Die Ergebnisse sprechen für eine vermehrte Stimulierbarkeit des humoralen Immunsystem im ZNS bei den erwähnten Erkrankungen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01478826
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  • 2
    Electronic Resource
    Electronic Resource
    Das Verhalten von Immunglobulin E bei mono- und polyklonaler Hypergammaglobulinämie (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 166-169 
    Details
    ISSN: 1432-1440
    Keywords: IgE ; hypergammaglobulinaemia ; IgE ; Hypergammaglobulinämie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 208 Patienten mit Hypergammaglobulinämie wurde der IgE-Serumspiegel mit dem Radioimmunassay gemessen. Die Ergebnisse zeigen keine generelle Beeinflussung des IgE-Serumspiegels bei Hypergammaglobulinämie. Eine Erhöhung des IgE-Spiegels ist bei der RA und chronisch entzündlichen Nierenerkrankungen nachweisbar. Erniedrigt sind die Spiegel bei Cirrhosen, Myelomen mit sekundärem Antikörpermangel und in geringem Grade bei Hämoblastosen und Retikulosen. Auch bei einer kleinen Gruppe von Hypergammaglobulinämikern ohne erkennbaren Organprozeß war der IgE-Spiegel erniedrigt. Unbeeinflußt ist er schließlich bei chronisch entzündlichen Prozessen des Darmtraktes, bei der chronisch aggressiven Hepatitis und bei Kollagenosen.
    Notes: Summary IgE was measured by radioimmunassay in 208 patients with different patterns of hypergammaglobulinaemia. In comparison to normal subjects no general influence on the serum level of IgE was seen. However, this was not true for different diseases. An increase was found in rheumatoid arthritis and in chronic inflammatory diseases of the kidney. IgE was decreased in cirrhosis, myeloma with secondary antibody-deficiency and malignoma of the reticulum. A group of patients with hypergammaglobulinaemia lacking other pathological findings also had a decreased IgE-level. In chronical inflammatory diseases of the intestine in active hepatitis, as well as in collagenoses IgE was not influenced. The results show that the kinetics of IgE is not influenced by the mechanisms controlling the other immunoglobulins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614391
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  • 3
    Electronic Resource
    Electronic Resource
    HB-Antigen in serum and synovialis in acute hepatitis with and withouth polyarthritis (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 927-928 
    Details
    ISSN: 1432-1440
    Keywords: HB-Antigen ; Hepatitis ; Polyarthritis ; HB-Antigen ; hepatitis ; polyarthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 27 patients suffering from acute hepatitis serum and synovial-fluid were tested for HB-Ag. It was detected in the serum in 19 cases, in the synovial fluid in 2 cases, but never in both serum and synovial-fluid. HB-Ag was not found in 6 patients. Polyarthritis was seen in 10 cases; 5 of them carried HB-Ag in the serum, 2 in the synovial-fluid. A hepatitis B however, was also suspected in the 3 cases with polyarthritis lacking HB-Ag. The results suggest that virus B may persist in joints too and that polyarthritis associated with acute hepatitis is coupled to an infection with virus B.
    Notes: Zusammenfassung Bei 27 Patienten mit akuter Hepatitis wurden Synovialis und Serum auf das HB-Ag untersucht. Es fand sich 19mal im Serum, 2mal in der Synovialis, aber niemals in beiden. Bei 6 Patienten wurde es nicht gefunden. Eine Polyarthritis bestand in 10 Fällen, von denen 5 das HB-Ag im Serum und 2 in der Synovialis hatten. Doch auch bei den übrigen 3 Fällen mit Polyarthritis ohne HB-Ag war eine Hepatitis B anzunehmen. Die Ergebnisse zeigen, daß das Hepatitis-B-Virus auch in Gelenken persistieren kann und eine Polyarthritis bei akuter Hepatitis an eine Infektion mit Virus-B gebunden ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468986
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of gammaglobulin injection on circulating immune complexes in various diseases (1979)
    Springer
    European journal of pediatrics 131 (1979), S. 43-48 
    Details
    ISSN: 1432-1076
    Keywords: Immunopathogenesis ; Infectious diseases ; Immune complexes ; Gammaglobulin injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immune complexes (ICs) participate in the pathogenesis of various diseases and can be shown in 18% of all hospitalized patients (excluding those with infectious diseases) by means of a sensitive method such as the Raji-cell radioimmune assay. However, before this test can be applied to quantify disease activity in renal, connective tissue and neoplastic diseases, it must be recognized that febrile infections of the upper respiratory tract also induce ICs in 86% of all patients. The immune complexes containing microbial antigens can be reduced or removed by a single injection of human immunoglobulin. This is a simple method to distinguish between the immune complexes of different specifities. The resulting removal of some immune complexes may be the explanation for the claimed therapeutic effect of gammaglobulin injection in normogammaglobulinemic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442784
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  • 5
    Electronic Resource
    Electronic Resource
    Goldbehandlung und Überlebenszeit bei Ehrlich Aszites Tumor (1973)
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 221-223 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung AKR-Mäuse, die eine Goldbehandlung erhielten, wurden zu verschiedenen Zeitpunkten mit unterschiedlichen Mengen an EAT-Zellen inokuliert. Entsprechende Kontrollgruppen erhielten lediglich dieselben Mengen an EAT-Zellen. Eine Änderung der durchschnittlichen Überlebenszeit von behandelten Tieren ergab sich nicht. Es überlebten jedoch signifikant (p〈0,05) mehr Tiere in der Gruppe der mit der geringsten Zellzahl von 5×103 inokulierten Serie, wenn die Goldbehandlung zum Zeitpunkt der Übertragung der EAT-Zellen begonnen worden war. Hieraus muß auf eine direkte Beeinflussung des Tumorwachstums durch Gold geschlossen werden.
    Notes: Summary AKR-mice were treated with gold and thereafter inoculated with different numbers of EAT-cells at different intervals. Controls were mice without chrysotherapy but inoculated with the same number of EAT-cells. Results show no remarkable change of the survival-time. The rate of takes of the EAT was significantly (p〈0,05) lower in animals inoculated with only 5×103 cells when inoculation was performed at the onset of chrysotherapy. Thus a direct interaction between tumour and gold is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304013
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of cytostatic drugs on blast cell transformation of lymph node and spleen cells (1973)
    Springer
    Research in experimental medicine 160 (1973), S. 196-205 
    Details
    ISSN: 1433-8580
    Keywords: Blast cell transformation ; Cytostatic drugs ; Immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different groups of NMRI-mice were given single doses of 2, 10, 50, 250 or 1000 mg/kg of Cph or 6-MP. Other groups were applicated 7×10 mg/kg every alternate day. 2 days after the last dose lymph node and spleen cells were collected and stimulated with PHA. Stimulation was estimated by the quotient of the uptake of3H-thymidine in stimulated and unstimulated cultures. Controls were untreated animals. It could be demonstrated that only maximal doses could inhibit the stimulation. Cph was more efficient than 6-MP. Lymph node cells were more sensitive than spleen cells. Repeated application showed no effect. The results demonstrate that cytostatic drugs can inhibit blast cell transformationin vivo. The different results are due to the different mode of action of those substances and from the different populations of harvested cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856783
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  • 7
    Electronic Resource
    Electronic Resource
    Kinetics of histamine released from rectal mucosa (1989)
    Springer
    Inflammation research 28 (1989), S. 164-167 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This kinetic study was performed to investigate the different tissue-influencing histamine amounts in Crohn's Disease (CD), Ulcerative Colitis (UC), patients with polyps and cancers (P.a.C.Gr) and in a Control Group (CG). For this purpose the endoscopically obtained specimens from rectal mucosa were immediately placed into 1000 μl of Hank's incubation medium in order to determine the spontaneously released histamine amounts at the time points of 5,10,15, 20 and 30 minutes. Each time a volume of 100 μl was removed from the incubation medium and the kinetic value (KV) was detected by using the single isotope radioenzymatic method. Influencing of natural histamine catabolism and the comparison of the tissue histamine release with or withour air oxygen in the incubation medium using four kinetic programmes (KP 1-4) provides clearly different KVs, not only betwen the KPs but also within the same KP. The P.a.C.Gr. shows higher kinetic values (KVs) compared with the CG. In KP 1-3 the kinetic courses (KCs) of the Inflammatory Bowel Diseases (IBDs), CD and UC-both not yet divided in active (a.) or not active (n.a.) disease stages-cross the KCs of the CG several times. Only the differentiation of the IBDs in active and not active disease stages in KP4 reveals that CDa. and UCa. stand out from the CG by higher KVs, and in contrast, CDn. a. and UCn.a. have lower KVs than the CG. The released amounts of histamine in CDa. and UCa. are significantly higher than in CDn.a. and UCn.a.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01967396
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  • 8
    Electronic Resource
    Electronic Resource
    Histamine release from human colonic mucosa in response to anti-IgE (1989)
    Springer
    Inflammation research 27 (1989), S. 89-92 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Testing of tissue particles for mediator release may be very useful for the diagnosis of localized immunological abnormalities or allergies. The aim of this study was to set up a general procedure to test the reaction of large bowel mucosa to stimuli via the IgE-mediated pathway. Therefore, tissue particles from normal subjects and from patients suffering from different diseases (Crohn's disease, ulcerative colitis, intestinal polyps) obtained at routine coloscopy were exposed to either Hanks or anti-IgE solution to determine the spontaneous or the anti-IgE-induced histamine release, expressed as the percentage of the total histamine content of the biopsy. Histamine was measured using the single isotope radioenzymatic assay. In general, whereas anti-IgE interestingly reduced the histamine release compared to the spontaneous in most of the patients within the polyps group, there was a stimulating effect of anti-IgE throughout all other groups. Thus, the study confirms the possibility of performing functional tests using biopsy particles from the colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02222207
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  • 9
    Electronic Resource
    Electronic Resource
    Regulation of antibody-formation in parabiosis (1972)
    Springer
    Research in experimental medicine 157 (1972), S. 87-94 
    Details
    ISSN: 1433-8580
    Keywords: Cellular Antibody-Formation ; Parabiosis ; Plaque-Technique ; Regulation of the Immune Response ; Celluläre Antikörperbildung ; Parabiose ; Immunregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Untersuchungen sollten zeigen, inwieweit bei Parabionten die Immunantwort gegenseitig beeinflußt werden kann. — NMRI-Mäuse wurden zu unterschiedlichen Zeitpunkten mit Hammelerythrocyten (HE) sensibilisiert und parabiontisch vereinigt. Durch Auszählen Antikörper-bildender Milzzellen wurde die Stärke der Immunantwort bestimmt, wobei die Plaque-Technik angewandt wurde. Durch Sensibilisieren eines einzigen Partners vor der Parabiose sollte gezeigt werden, ob einzelne Antikörper-bildende Zellen oder HE durch die Anastomose übertreten. Die Ergebnisse zeigen eine gegenseitige Beeinflussung der Immunantwort. Da einzelne Antikörper-bildende Zellen oder HE nicht übertreten, ist dieser Effekt allein zirkulierenden Antikörpern zuzuschreiben. Sie führen zu einer Hemmung der Immunantwort insbesondere bei Tieren, die kurz vor der Parabiose sensibilisiert worden sind. Die Ergebnisse bestätigen das Vorliegen eines Rückkoppelungsmechanismus und beweisen darüber hinaus, daß die Unterdrückung durch direktes Einwirken auf die Antikörper-bildenden Zellen erfolgt.
    Notes: Summary This work was designed to show whether antibodies can influence the immune responseafter sensitization. — NMRI-mice were sensitized with sheep red blood cells (SRBC) and joined by parabiosis. After different intervals the immune response was examined by detection of single antibody-forming cells using the plaque-technique. For demonstration of a possible transfer of SRBC or antibodyproducing cells only one parabiont was sensitized. The results show a mutual influence of the immune response of both parabionts. Because there is no transfer of SRBC or antibody-producing cells through the communication the influence is due to passing antibodies. Those antibodies inhibit the immune response more when animals are sensitized few days before parabiosis. The suppression of the antibody-formation in animals sensitized before parabiosis is an indication for a direct interaction of antibodies with cells producing them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851690
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  • 10
    Electronic Resource
    Electronic Resource
    Histologischc Überprüfung der Überlebensdauer elektrisch durchströmter Haut-Homoiotransplantate bei Kaninchen (1966)
    Springer
    Clinical and experimental medicine 141 (1966), S. 257-262 
    Details
    ISSN: 1591-9528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Histological control of the survival of rabbitskin-homografts pretreated with electrical current. The histological examination of skin-homografts pretreated with electrical current proves the survival-time to be prolonged for more than 3 weeks. The reversible cellular alteration due to electrical current and the arising hypothesis are discussed.
    Notes: Zusammenfassung Die histologische Kontrolle elektrisch vorbehandelter Haut-Homoiotransplantate beweist eine Verlängerung der Überlebensdauer auf über 3 Wochen. Die sich aus dem Nachweis dieser reversiblen Zellveränderung ergebende Hypothese wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043338
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