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  • 1
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Report of three cases of acute myelosis with the presence of two erythrocyte populations. The patients were of blood groups A1; A2 and B. The percentage of erythrocytes not agglutinable by anti-A or anti-B sera varied between 5% and 22%—on the average between 10% and 17%. Isolated free corpuscles of patients A1 and A2 groups showed no H/O-specificity. The anti-human deviation method showed that there was practically no blood group agglutinin on the surfaces of the non agglutinable isolated red corpuscles. Admixture of agglutinated erythrocytes in suspensions of free erythrozytes gave weak positive results in the direct Antiglobulin test and also in the elution test. The A2 patient had been found to belong to this group a year before the onset of his illness and was still so in the first month, but was also found to be A1. In this case therefore, two changes had occurred:—regression of agglutinability and the development of two erythrocyte populations. In another case of subacute leukaemia of blood group A1B, the presence of all four ABO-erythrocyte types, d.i.O.B. and AB was demonstrated. Because of earlier transfusion this phenomenon is not quite clear-cut, although calculation of the percentage of ‘free’ erythrocytes. The reliability of the technique, the question of the groups of the non-agglutinable erythrocytes and the dependence of the results on the patient's clinical condition are discussed.
    Notes: Zusammenfassung Es wurde über 3 Fälle von akuter Myelose mit Vorkommen von 2 Erythrozytenpopulationen berichtet. Es handelt sich um die Kranken der Blutgruppen A1, A2 und B; der Prozentsatz der mit Anti-A- oder Anti-B-Seren nichtagglutinablen Erythrozyten schwankte bei ihnen zwischen 5% und 22%, durchschnittlich zwischen 10% und 17%. Die isolierten freien Blutkörperchen von Kranken der A1- und A2-Gruppe zeigten keine H/O/-Spezifität. Die Antihumanglobulin-Ablenkungsmethode bewies, daß an der Oberfläche der isolierten nichtagglutinablen Blutkörperchen praktisch keine Blutgruppenagglutinine gebunden wurden. Schwach positive Ergebnisse des direkten Antiglobulintestes und des Elutionstestes bezeugen die Beimengung von agglutinierten Erythrozyten in Suspensionen von freien Blutkörperchen. Der Kranke der Blutgruppe A2 wurde 1 Jahr vor Beginn der Erkrankung und noch im ersten Monat der Krankheit als A1 bestimmt; es wurden daher bei ihm 2 Veränderungen—der Agglutinabilitätsrückgang und die Entstehung von 2 Erythrozytenpopulationen—kombiniert. Bei einem weiteren Fall subakuter Leukämie der Blutgruppe A1B wurde die Anwesenheit von allen 4 ABO-Erythrozytentypen, d. i. O, A, B und AB nachgewiesen. Wegen vorheriger Transfusion des A- und B-Blutes bleibt jedoch dieses Phänomen diskutierbar, obgleich die Ausrechnung des Prozentsatzes der überlebenden A- und B-Blutkörperchen einen wesentlich geringeren Wert zeigte als bei der Untersuchung “freier” Erythrozyten. Die Verläßlichkeit der Methodik, die Frage der Blutgruppenzugehörigkeit von nichtagglutinablen Erythrozyten und die Abhängigkeit der Resultate vom klinischen Stand der Kranken wurden diskutiert.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 20 (1993), S. 0 
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Coeliac disease (CD) is associated with particular HLA genotypes. The susceptibility gene (or genes) has been mapped to the class II region, most probably to the DQ loci. Polymorphism of the upstream promoter region of the DQA1 gene (QAP) has been recently reported. At least ten variants or QAP alleles have been found, some of which are present in the as-acting regulatory sequences. Allelic differences in DQ molecule expression may play a role in susceptibility to CD. We investigated the QAP polymorphism in 102 CD patients and 142 unrelated healthy controls of Czech origin using polymerase chain reaction amplification (PCR) of genomic DNA and oligonucleotide probes. We found a significant frequency increase of the alleles QAP 4.1 (RR = 10.3, p.c. = 10-6) and QAP 2.1 (RR = 2.4, p.c. = 0.017) in patients over controls. An increased susceptibility is provided by the presence of both alleles, as is shown by the higher proportion of QAP 4.1, 2.1 heterozygotes among patients than expected from the Hardy-Weinberg equilibrium and by the comparison of the odds ratios for these alleles. There is a strong linkage disequilibrium between the QAP alleles and the DQA1, DQB1, and DRB1 loci. Two haplotypes carrying the QAP alleles whose frequency is increased are predominant in this group of CD patients: DQB1* 0201, DQA1* 0501, QAP 4.1, DRB1* 0301 and DQB1* 0201, DQA1* 0201, QAP 2.1, DRB1* 0701. Thus, the QAP variants are increased as part of these haplotypes and we cannot discriminate if they are responsible for the primary association.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 5 (1974), S. 789-794 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    General and Comparative Endocrinology 10 (1968), S. 235-239 
    ISSN: 0016-6480
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 16 (1960), S. 201-202 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The plasmatic fraction, which is precipitated by cooling human heparin plasma, has been found to contain the constituent identical withγ-globulin and also another component with the fibrinogen of Cohns' fraction I immunologically identical. With the help of the agar-gelose diffusion method, no qualitative immunological differences have been found with regard to the antigenous composition of the plasmatic fraction isolated in cases of various system diseases.
    Type of Medium: Electronic Resource
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