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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 107 (1985), S. 7027-7039 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 14 (1969), S. 14-18 
    ISSN: 1432-0533
    Keywords: Peroxidase Transport ; Fetal Choroid Plexus ; Tracer Protein ; Vascular Compartment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Des observations sont presenté sur l'absorption et le transport du protein «horse radish» peroxidase par le plexus choroidien du rat pendant sa maturation. Dans tout les animaux injectés les produits de réaction de peroxidase étaient identifiés dans les membranes basales et latérales et les espaces intercéllulaires. Aucun trace de peroxidase n'était demonstré à l'interieure des cellules epithéliales du plexus avant l'age de 4–5 jours.
    Notes: Summary The uptake and transport of the tracer protein horse-radish peroxidase was studied in the developing choroid plexus of the rat. In all age groups the tracer was identified in the vascular compartment and in intercellular spaces but none was present within choroidal epithelial cells prior to the 4th to 5th day post partum.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 15 (1966), S. 109-119 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This investigation had the aim of examining the intellectual capacity of patients with operatively treated obstructive hydrocephalus. The series studied consisted of 16 males and 14 females operated on between 1956 and 1962. For the assessment of the patients psychological tests, among them a general intelligence test, were drawn upon. The test results of randomly selected patients in this group were compared with the test results of a group of randomly selected clinically unrelated patients and the differences were examined statistically. The investigation showed that in patients with operatively treated obstructive hydrocephalus minimal signs of organic brain damage develop. They were recognisable only in small areas of function. The preservation of the functions was dependant upon their degree of complexity. Diminished capacities revealed themselves partly only when the tests were performed at an accelerated tempo. The type of intellectual disturbances encountered lay in the field of a non-specific organic brain syndrome.
    Abstract: Résumé Les investigations exposées dans cette étude, ont eu pour but d'évaluer la capacité intellectuelle de patients opérés d'hydrocéphalie obstructive. La série de malades pris en considération, comportait seize hommes et quatorze femmes, opérés entre 1956 et 1962. Une estimation a été obtenue è l'aide de tests psychologiques, entre autre le test d'intelligence générale. Les résultats des tests pratiqués chez des patients choisis au hasard dans ce groupe, ont été comparés aux résultats des tests pratiqués chez un groupe de patients choisis selon la mÊme méthode et sans similitude clinique. Les différences ont été examinées statistiquement. Toutes ces investigations ont montré que les sujets opérés d'hydrocéphalie obstructive présentaient des signes minimes de dommages organiques cérébraux. Ces derniers ne se reconnaissaient que dans un domaine fonctionnel trés restreint. La préservation des fonctions dépendait de leur degré de complexité; des capacités diminuées ne se révélant seulement partiellement que lorsque les tests étaient effectués à un rythme accéléré. Le type de perturbations intellectuelles rencontrées chez ces patients se rangeait parmi les syndromes organiques cérébraux non spécifiques.
    Notes: Zusammenfassung Die vorliegende Untersuchung hatte das Ziel, die geistige Leistungsfähigkeit von Patienten mit operativ behandeltem Verschlußhydrozephalus zu überprüfen. Das Krankengut bestand aus 16 Männern und 14 Frauen, die zwischen 1956 und 1962 operiert worden waren. Zur Prüfung wurden verschiedene psychologische Tests, darunter ein allgemeiner Intelligenztest, herangezogen. Die Testergebnisse der Patienten-Stichprobe wurden mit den Testergebnissen einer nicht-klinischen Parallel-Stichprobe verglichen und die Differenzen statistisch überprüft. Die Untersuchung zeigte, daß bei Pat. mit operativ behandeltem Verschlußhydrozephalus leichteste hirnorganische Abbauerscheinungen bestehen. Sie waren nur in wenigen Funktionsbereichen nachzuweisen. Die Resistenz der Funktionen war von ihrem Komplexitätsgrad abhängig. Leistungsabfälle zeigten sich teilweise nur unter erhöhtem Tempo. Qualitativ liegen die Störungen im Rahmen eines unspezifischen hirnorganischen Syndroms.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 52 (1954), S. 348-352 
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0925-4773
    Keywords: Eph ; Hindbrain ; Rhombomere ; Segmentation ; Sek ; Tyrosine kinase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Resource and Energy Economics 16 (1994), S. 303-319 
    ISSN: 0928-7655
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Economics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Hayfever is determined by an interaction of environmental and genetic factors and biologically characterized by an imbalanced T helper cell 1 (Th1) and Th2 immune response and elevated IgE levels against inhalant allergens. Indications exist that polymorphisms in cytokine genes involved in the regulation of the Th1/Th2 balance may contribute to the allergic phenotype.Objective We investigate whether polymorphisms in genes directly or indirectly involved in Th1, Th2 immune response are associated with hayfever and elevated IgE levels against inhalant allergens.Methods From a subsample of the European Prospective Investigation into Cancer and Nutrition-Heidelberg, 322 subjects with hayfever and 322 age- and sex-matched non-allergic controls were selected and genotypes determined for 15 polymorphisms in 13 genes. Plasma IgE against inhalant allergens was measured via CAPSX1 (Phadiatop) test. We computed odds ratios (ORs) by logistic regression, tests on group differences of IgE-levels in dependence upon genotype and tests for trend by means of non-parametric methods.Results We found decreased OR for hayfever (OR=0.60, 95%CI=0.4–0.9) and sensitization to inhalant antigens (OR=0.5, 95%CI=0.4–0.8) in heterozygotes of the IL-6 −174 G/C polymorphism. Homozygotes of the G-allele in IL-2 −330 T/G were at increased risk of hayfever (OR=2.6, 95%CI=1.3–5.2). Moreover, we found indications for differences in IgE levels against inhalant allergens in dependence upon genotypes of polymorphisms in IL-4R, IL-6, IL-13, and IL-18.Conclusion Our data suggest an association of genetic variants in IL-6 and IL-2 with hayfever, confirm a role of polymorphisms in IL-4R, IL-13, and IL-18 for the elevated IgE phenotype, and add IL-6 to the list of candidate genes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mathematical Biosciences 120 (1994), S. 147-163 
    ISSN: 0025-5564
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Mathematics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 125 (1976), S. 115-127 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Allergy 58 (2003), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The objective of the investigation was to explore in a prospective study the associations between dietary intake of fatty acids, antioxidants and hay fever manifestation in adulthood.Methods:  Three hundred and thirty-four hay fever cases with adult onset of clinical symptoms from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 1336 controls. Dietary intake data were obtained by means of validated food frequency questionnaires. The influence of dietary fatty acid and vitamin intake on hay fever risk was estimated by means of unconditional logistic regression.Results:  High intake of oleic acid was positively associated with hay fever [odds ratio (OR): 2.86, 95% confidence intervals (95% CI): 1.22–6.70], whereas high intake of eicosapentaenoic acid was inversely related to hay fever (OR: 0.45, 95% CI: 0.22–0.93). Furthermore, high β-carotene intake increased the risk of hay fever (OR: 1.69, 95% CI: 1.09–2.63) while increasing intake of vitamin E was a protective factor (OR: 0.38, 95% CI: 0.17–0.85). In grouped analyses, the effects of β-carotene and vitamin E were mainly observed among women and ex-/current-smokers; in these subgroups, linoleic acid increased the risk of hay fever.Conclusions:  In conclusion, the present results provide further evidence that dietary factors might affect the risk of clinical manifestation of hay fever. However, the effects in smokers and women may suggest different biological mechanisms for the investigated nutrients, which need further research.
    Type of Medium: Electronic Resource
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