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  • 1
    Electronic Resource
    Electronic Resource
    Psychiatric symptoms as late onset of Wilson's disease: neuroradiological findings, clinical features and treatment (1999)
    Springer
    Italian journal of neurological sciences 20 (1999), S. 49-54 
    Details
    ISSN: 1126-5442
    Keywords: Key words Hepatolenticular degeneration ; Affective disorders ; Magnetic resonance imaging ; Antidepressive agents ; Interpersonal psychotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe a case of Wilson's disease with late psychiatric onset. Major depressive disorder was the first clinical manifestation at the age of 38 years. After pharmacotherapy with antidepressive agents, a manic episode was oberseved. Extrapyramidal hand tremor and micrography were the first neurological signs. Emotional lability occurred during worsening of extrapyramidal signs. Diagnosis was based on urinary and serum copper levels, ceruloplasmin serum level, Kayser-Fleischer ring, and liver biopsy that detected cirrhosis. Magnetic resonance imaging revealed basal ganglia hyperintensity on T1-weighted images, and hypodensity in the central part and hyperintensity in the peripheral part of the lentiform nucleus on 72-weighted images. Hyperintensity on T2-weighted images was also observed in the dorsal part of the midbrain. 123I-iodobenzamide single photon emission computed tomography (IBZM-SPECT) detected a normal distribution of the drug in the brain, with better signal in the right side and deficit of D2-dopaminergic receptors in the basal ganglia, Abnormal manganese erythrocyte level was observed. Treatment was based on penicillamine, zinc salts, low-copper diet, antidepressant agents, interpersonal psychotherapy and neurorehabilitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100720050010
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for a Glycidic-Lipidic Matrix in Human Neuromelanin, Potentially Responsible for the Enhanced Iron Sequestering Ability of Substantia Nigra (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 62 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The high-resolution solid-state 13C-NMR spectrum of a neuromelanin specimen (from patients dying from nonneurological diseases) is compared with that obtained from enzymatically prepared dopamine-melanin. The main differences between the two spectra suggest the occurrence in neuromelanin of a glycidic/lipidic matrix tightly associated with the melanin macromolecule. Atomic emission spectroscopy revealed high iron content (1.5%) in the neuromelanin specimen, in full agreement with previous reports. These observations support the view that neuromelanin acts as a strong chelating (and insolubilizing) system for iron ions and further suggest that the attack to this compact composite substrate may be an important step to allow the release of iron ions responsible for the increased lipid peroxidation reported in the pathogenesis of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.62010369.x
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  • 3
    Electronic Resource
    Electronic Resource
    Idebenone in the treatment of multi-infarct dementia: a randomised, double-blind, placebo controlled multicentre trial
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 15 (1992), S. 271-278 
    Details
    ISSN: 0167-4943
    Keywords: Assessment variables ; Idebenone ; Multinfarct dementia ; Placebo ; Senile mental involution ; Visual-perceptive capabilities
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(92)90062-9
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of idebenone in elderly subjects with cognitive decline. Results of a multicentre clinical trial
    Amsterdam : Elsevier
    Archives of Gerontology and Geriatrics 15 (1992), S. 279-286 
    Details
    ISSN: 0167-4943
    Keywords: Cognitive decline ; Idebenone ; Memory impairment ; Neurological deficits ; Oxiracetam
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4943(92)90063-A
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  • 5
    Electronic Resource
    Electronic Resource
    An analysis of peripheral type benzodiazepine receptors on blood mononuclear cells during high dose steroid treatment of multiple sclerosis (1992)
    Springer
    Neurological sciences 13 (1992), S. 685-691 
    Details
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; peripheral benzodiazepine receptors ; mononuclear cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario In questo studio riportiamo le caratteristiche dei recettori benzodiazepinici di tipo periferico (pBZr) in cellule mononucleate (MNC) isolate dal sangue di pazienti con sclerosi multipla (SM), in fase attiva o stabile, e di controlli normali. Abbiamo osservato una significativa riduzione della densità recettoriale nelle cellule dei pazienti con SM attiva comparati con i controlli, mentre non abbiamo trovato nessuna alterazione in quelle dei pazienti con SM in remissione. Nei pazienti con SM attiva il trattamento steroideo induce una normalizzazione della densità recettoriale e la sospensione è associata con un modesto aumento dei siti di legame rispetto ai controlli. I nostri dati suggeriscono che la densità dei pBZr nelle MNC di pazienti con SM potrebbe variare in relazione sia al decorso clinico che al trattamento con steroidi.
    Notes: Abstract We report here a study of peripheral type benzodiazepine receptors (pBZr) in mononuclear cells (MNC) from blood of patients with multiple sclerosis (MS) during periods of stable and active disease and from normal controls. Most active MS patients were retested in a longitudinal study, both during a treatment with high dose steroids and while medication free. Active MS produces a significant decrease of receptor density compared with the controls whereas remission of the disease shows no effect. Four weeks of steroid treatment restore binding density to normal levels, and two weeks of drug withdrawal result in a small, but significant increase in number of the binding sites compared with the control value. We suggest that the number of pBZr in blood MNC might change during the clinical course and steroid therapy of MS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02334972
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  • 6
    Electronic Resource
    Electronic Resource
    Single-blind, placebo-controlled multicenter trial of vigabatrin in the treatment of epilepsy (1992)
    Springer
    Neurological sciences 13 (1992), S. 741-747 
    Details
    ISSN: 1590-3478
    Keywords: Vigabatrin ; epilepsy ; anticonvulsants ; clinical trial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Centouno pazienti affetti da epilessia farmaco-resistente (nella maggior parte dei casi con crisi parziali) sono stati inclusi in uno studio policentrico con vigabatrin somministrato in aggiunta alla terapia preesistente secondo un disegno sperimentale controllato in singolo cieco. Il protocollo prevedeva 4 fasi consecutive (osservazione basale, placebo, vigabatrin 2 g/die, vigabatrin a dose individualizzata in base alla risposta clinica, sino ad un massimo di 4 g/die), ciascuna della durata di 8 settimane ad eccezione della fase di ottimizzazione della posologia che poteva essere prolungata a 16 settimane. Novanta pazienti hanno completato lo studio, mentre 11 (tra cui 1 che ha presentato stato di piccolo male e 4 che hanno riferito un aumento della frequenza delle crisi) hanno interrotto il trattamento precocemente. Nei pazienti che hanno completato lo studio, la frequenza mensile delle crisi è diminuita da un valore mediano di 16 (range interquartile 8–34) durante placebo a 5 (2–10) durante l'ultima fase di trattamento con vigabatrin (p〈0.0001). Sia le crisi parziali che le crisi generalizzate tonico-cloniche (per lo più secondariamente generalizzate) sono diminuite significativamente. Una riduzione delle crisi di oltre il 50% è stata osservata in 60 pazienti. Gli effetti collatterali più frequentemente osservati sono stati sedazione ed aumento ponderale.
    Notes: Abstract A single-blind, placebo-controlled multicenter trial of vigabatrin was carried out in 101 epileptic patients (mostly with partial seizures) refractory to conventional therapy. The study design included four consecutive periods: (i) an observation phase (run-in), (ii) a placebo period, (iii) fixed-dosage add-on vigabatrin (2 g/day) and (iv) dose titration (up to a maximum of 4 g/day) to optimize clinical response. Each period lasted 8 weeks, except for the titration phase, which could be extended to 16 weeks. 90 patients completed the trial. Eleven dropped out, one patient developing absence status and 4 cases showing an increased seizure frequency. In the patients completing the trial, the median number of seizures/month decreased from 16 (inter-quartile range 8–34) during placebo to 5 (2–10) during the last 8 weeks on vigabatrin (p〈0.0001). Both partial and generalized tonic clonic (mostly secondary) seizures were significantly reduced. A greater than 50% reduction in seizure frequency (compared to placebo) was observed in 60 patients. Sedation and weight gain were the most frequently reported adverse events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229159
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  • 7
    Electronic Resource
    Electronic Resource
    Associated polyneuropathy and demyelinating disease. Case report (1992)
    Springer
    Neurological sciences 13 (1992), S. 793-796 
    Details
    ISSN: 1590-3478
    Keywords: Polyneuropathy ; demyelinating disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene presentato un caso in cui ad una sindrome acuta tipo Guillain-Barré è successivamente seguita una malattia demielinizzante centrale, come documentato dal quadro clinico, dalla Risonanza Magnetica Nucleare (RMN), dalle indagini elettrofisiologiche e liquorali. La particolare sequenza temporale della sintomatologia clinica sembra escludere una semplice coincidenza di due malattie distinte e sembra costituire una ulteriore prova di un possibile legame eziologico tra un danno mielinico centrale e periferico. Viene discussa la possibilità che un comune fattore patogenetico possa essere responsabile di demielinizzazione centrale e periferica.
    Notes: Abstract We report a case in which an acute Guillain-Barré-like syndrome was quickly followed by a central demyelinating disease, documented by the clinical findings as well as by magnetic resonance imaging (MRI), electrophysiological and cerebrospinal fluid examinations. The close follow-on of the clinical signs seems to exclude a simple coincidence of two separate diseases and it may constitute further evidence for a possible etiological link between central and peripheral myelin damage. We discuss the possibility of a common pathogenic factor underlying central and peripheral demyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229166
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  • 8
    Electronic Resource
    Electronic Resource
    Primary antiphospholipid syndrome (1995)
    Springer
    Neurological sciences 16 (1995), S. 391-392 
    Details
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02229175
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  • 9
    Electronic Resource
    Electronic Resource
    Brain-stem auditory evoked potential alterations in heroin addicts (1985)
    Springer
    Journal of neurology 232 (1985), S. 262-262 
    Details
    ISSN: 1432-1459
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313791
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  • 10
    Electronic Resource
    Electronic Resource
    Acute neurologic complications of hemodialysis (1981)
    Springer
    Neurological sciences 2 (1981), S. 53-57 
    Details
    ISSN: 1590-3478
    Keywords: Hemodialysis ; chronic renal failure ; “Disequilibrium syndrome”
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Abbiamo censito e sottoposto ad indagine statistica le complicanze neurologiche acute transitorie insorgenti nel corso di emodialisi in 103 pazienti con insufficienza renale cronica (sono state esaminate 13.969 emodialisi). Dai nostri dati risulta che tali complicanze consistono di una sintomatologia multiforme: parte dei sintomi presentati dai pazienti sono aspecifici (cefalea, nausea e/o vomito, crampi muscolari). Sono presenti in oltre il 96% dei pazienti, associati a sintomi e fenomeni extraneurologici, quali collasso circolatorio o aumento di pressione arteriosa). Altri sintomi denotanti una vera compromissione cerebrale (convulsioni, disturbi di coscienza, agitazione psicomotoria) sono meno frequenti (compaiono nel 36% dei pazienti) e solo il 10,5% dei soggetti presenta un'associazione di almeno due di questi sintomi, configurando una “Sindrome da disequilibrio”, con percentuale, nel nostro campione, analoga a quella riferita in letteratura.
    Notes: Abstract We have examined and subjected to statistical analysis the transient acute neurological complications arising in the course of hemodialysis in 103 patients with chronic renal failure (13,969 hemodialysis sessions). Our data show that such complications are multiform. Some of the symptoms are aspecific: headache, nausea and/or vomiting, muscle cramps. We have found these symptoms in over 96% of patients, often combined with extraneurological symptoms and phenomena, such as cardiocirculatory shock or increased blood pressure. The other symptoms denote real cerebral impairment: convulsions, consciousness disturbances, psychomotor agitation. They are present in 36% of the patients, but only 10.5% of the patients show a combination of at least two symptoms. In these patients the so-called “Disequilibrium syndrome” is present: its percentage in our case-series is similar to that reported in leterature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02351687
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