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  • 1
    Electronic Resource
    Electronic Resource
    Insulin and glucagon secretion in diabetic and non-diabetic patients with circulating islet cell antibodies (1977)
    Springer
    Diabetologia 13 (1977), S. 451-458 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes ; autoimmunity and diabetes ; islet cell antibodies ; insulin and glucagon secretion ; glucose and arginine infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-nine patients (14 non-diabetics, 8 chemical diabetics, and 17 overt diabetics) with circulating islet cell antibodies (ICA) were studied. Insulin and glucagon secretion after oral (100 g) and intravenous glucose loading (200 mg/kg bolus injection followed by an infusion of 20 mg/min over 60 min) and arginine infusion (25 g over 30 minutes) were evaluated in these patients and in non diabetic and diabetic ICA-negative controls. In the non-diabetic groups with or without ICA, insulin and glucagon responses to glucose were similar. Moreover, in ICA positive patients the response of these hormones to arginine infusion was reduced. Similar alterations in insulin and glucagon secretion were observed in the ICA positive and negative patients with chemical or overt diabetes. In particular, fasting hyperglucagonaemia and glucagon hyperresponse to arginine are associated with a lack of insulin secretion in the patients with overt diabetes. Hormonal differences between diabetics with and without ICA could not be detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01234495
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies (1981)
    Springer
    Diabetologia 21 (1981), S. 47-50 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; T and B lymphocytes ; islet-cell antibodies ; autoimmunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lymphocyte subpopulations of 26 insulin-dependent diabetics were studied. Thirteen of them had persistent pancreatic islet-cell serum antibodies (ICA) (mean (± SD) duration of diabetes 11 ±8 years). The others were ICA-negative (mean duration of diabetes 10±8 years). The mean fasting blood glucose in the week before the lymphocyte count was 1.37±0.45 g/l (two specimens for every patient). As controls 19 healthy volunteers, sex and age matched, were investigated. The T-lymphocyte count was no different in diabetics compared to controls, B-cells were significantly raised (p〈0.01) in the ICA-positive group, when tested with antihuman gammaglobulin sera (IgG + IgA + IgM), anti-human IgG and anti-human IgM, while no difference as observed between ICA-negative patients and normal subjects. IgA-bearing lymphocytes were equally raised in both diabetic groups (p〈0.05). These data show an altered immunological balance in type IB (autoimmune) diabetes, characterized by an increased number of B-lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01789113
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoantibodies (1981)
    Springer
    Diabetologia 20 (1981), S. 47-50 
    Details
    ISSN: 1432-0428
    Keywords: Insulin-dependent diabetes mellitus ; T and B lymphocytes ; islet-cell antibodies ; autoimmunity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The lymphocyte subpopulations of 26 insulin-dependent diabetics were studied. Thirteen of them had persistent pancreatic islet-cell serum antibodies (ICA) (mean (±SD) duration of diabetes 11 ± 8 years). The others were ICA-negative (mean duration of diabetes 10±8 years). The mean fasting blood glucose in the week before the lymphocyte count was 1.37±.45 g/1 (two specimens for every patient). As controls 19 healthy volunteers, sex and age matched, were investigated. The T-lymphocyte count was no different in diabetics compared to controls, B-cells were significantly raised (p 〈0.01) in the ICA-positive group, when tested with antihuman gammaglobulin sera (IgG + IgA + IgM), anti-human IgG and anti-human IgM, while no difference was observed between ICA-negative patients and normal subjects. IgA-bearing lymphocytes were equally raised in both diabetic groups (p 〈0.05). These data show an altered immunological balance in type IB (autoimmune) diabetes, characterized by an increased number of B-lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00253816
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ethological predictors of amitriptyline response in depressed outpatients
    Amsterdam : Elsevier
    Journal of Affective Disorders 17 (1989), S. 129-136 
    Details
    ISSN: 0165-0327
    Keywords: Ethological predictors ; Tricyclic treatment ; Unipolar depression
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-0327(89)90035-9
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    HLA antigens and neuroleptic response in clinical subtypes of schizophrenia
    Amsterdam : Elsevier
    Journal of Psychiatric Research 23 (1989), S. 213-220 
    Details
    ISSN: 0022-3956
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3956(89)90026-5
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    99mTc-HIDA dynamic scintigraphy for the diagnosis of gastroesophageal reflux of bile (1985)
    Springer
    European journal of nuclear medicine 10 (1985), S. 549-550 
    Details
    ISSN: 1619-7089
    Keywords: Bile reflux ; HIDA 99mTc hepatobiliary scintigraphy ; Gastroesophageal reflux
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 5 patients with partial gastric resection and esophagitis, in whom esophageal pH metry was unable to demonstrate significant gastroesophageal reflux (GER), we administered i.v. 5 mCi (185 MBq) of 99mTc-HIDA, the patient lying under a computer-assisted LFOV gamma camera. When gallbladder image was evident, caerulein was administered i.v. at a physiologic dose in order to induce gallbladder contraction, and in the subsequent 45 min the patient was asked to perform a standard series of manoeuvres that increase the intraabdominal pressure (Valsalva, etc.) and favour GER. Scintigraphic images and time/activity curves obtained from areas of interest corresponding to gastric remnant and distal esophagus showed that at least one of these manoeuvres in each case was followed by the appearance of the radiocompound in the distal esophagus, indicating a 99mTc-HIDA-tagged bile GER. Consequently, we believe that HIDA-GER dynamic scintigraphy may be more useful than esophageal pH metry in demonstrating the biliary origin of an esophagitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00252750
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Further studies on CELO virus: Its relationship to the adenovirus group (1964)
    Springer
    Archives of virology 14 (1964), S. 637-649 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CELO virus is resistant to trypsin at 37° C; it is not stabilized by 1M MgCl2 at 50° C. The multiplication of CELO is inhibited by iododeoxyuridine, a drug which selectively inhibits DNA viruses. In growth studies, it was found that the titer of the cell-associated virus is more than 100 times higher than the extra-cellular one. Some electron microscopic pictures are presented, showing the reaction of the nuclear components to viral multiplication, the occurrence of “ring-like bodies”, small irregular bodies, and the release of virus in the extracellular space. All here described properties of CELO are common to adenoviruses, a further evidence that CELO should be classified in the adenovirus group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01555121
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    Paper (German National Licenses)
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