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  • 1
    Electronic Resource
    Electronic Resource
    Studies on Etiologic Factors in Pemphigus (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 3 (1976), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A survey of 234 cases of pemphigus yielded three observations which suggest that different forms of pemphigus may have different etiologies.1. While the incidence of pemphigus in the age group of 21 and over was essentially the same in males and females (108 and 113) the incidence was significantly higher in females in the age group under 20. Only two of 13 patients in this group were males. Also pemphigus foliaceus and erythematosus was reported in a significantly higher proportion of the cases in the age group of 2 1/2 to 20 thus suggesting that the juvenile form of the discase differs from the adult form.2. In four of a group of 15 cases identified as pemphigus foliaceus the disease appeared to be provoked by minor physical insults, a frequency which is significantly higher than the five cases with similar histories in the group of 198 cases identified as pemphigus vulgaris.3. In the entire group of 234 cases two patients with pemphigus both proven by immunofluorescence had relatives with pemphigus. Also a third patient had a blood relative with bullous pemphigoid. This frequency of three per 234 is higher than would be expected by chance. Studies of one family (not included in this survey) with multiple skin antibodies suggest that such familial predispositions may be due to abnormal immune responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1976.tb00849.x
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  • 2
    Electronic Resource
    Electronic Resource
    SEROLOGIC STUDIES OF MYASTHENIA GRAVIS (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 124 (1965), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1965.tb18997.x
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  • 3
    Electronic Resource
    Electronic Resource
    FACTORS CONTRIBUTING TO OCCASIONAL FAILURES IN THE LABORATORY DIAGNOSIS OF BULLOUS PEMPHIGOID BY INDIRECT IMMUNOFLUORESCENCE (1972)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 86 (1972), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary.— The basement membrane antibodies in 3 sera of patients with bullous pemphigoid were studied by means of indirect immunofluorescent staining chessboard titrations on monkey, rabbit and guinea-pig lip tissue. Comparisons of the results of these studies with those obtained in previous studies of this type with 2 other sera, revealed wide variations in the spectra of specificities of the bullous pemphigoid antibodies. Monkey oral or oesophogeal mucosa appears to be the substrate of choice for routine tests for these antibodies, although this must be regarded as an approximation of the “ideal antigen”.The implication of these findings are discussed both from the practical and theoretical points of view.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1972.tb16072.x
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  • 4
    Electronic Resource
    Electronic Resource
    THE DIAGNOSIS OF PEMPHIGUS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 84 (1971), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1971.tb02549.x
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  • 5
    Electronic Resource
    Electronic Resource
    PSEUDO-PYOSTOMATITIS VEGETANS (1995)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 34 (1995), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1995.tb01105.x
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  • 6
    Electronic Resource
    Electronic Resource
    Tuberculosis of the skin: historical perspectives on tuberculin and Bacille Calmette Guérin (1997)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 36 (1997), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.1997.00027.x
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  • 7
    Electronic Resource
    Electronic Resource
    In vitro effects of pemphigus antibodies on skin (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Acantholysis occurring in rhesus monkey skin explants cultured on sera of 9 pemphigus patients was found to be largely dependent on the titre of intercellular antibody, and not on the participation of complement. Skin explants cultured on normal human sera and pemphigoid sera failed to give rise to intercellular staining or to develop lesions.Six of eight ‘negative’ pemphigus sera with intercellular antibody titres of less than 20 on skin (and titres ranging from 20 to 160 on monkey oesophagus) reacted with the skin explants as revealed by direct immunofluorescence with an anti-IgG conjugate. The binding of antibodies from 3 of these 6 reactive sera resulted in some pathological changes in the explants. At least two of these 3 ‘negative’ sera came from pemphigus patients with skin lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb01958.x
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  • 8
    Electronic Resource
    Electronic Resource
    CHRONIC ULCERATIVE STOMATITIS WITH STRATIFIED EPITHELIUM-SPECIEIC ANTINUCLEAR ANTIBODIES (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 35 (1996), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. In 1990 a new disease-associated antinuclear antibody was first recognized as a specific immunologic marker for a chronic form of ulcerative stomatitis (cus). Methods. Another case is reported herein and the subject of chronic ulcerative stomatitis with stratified epithelium-specific antinuclear antibodies (SES-ANA) is reviewed. Intraoral biopsies from this patient were submitted for microscopic examination and direct immunofluorescence. Indirect immunofluorescence studies were also performed. Serial SES-ANA titers were obtained with the patient on maintenance treatment with hydroxychloroquine. A skin biopsy of a recent lichenoid eruption was obtained and skin explants grown in the serum of this patient were studied in tissue culture with reference to SES-ANA binding and complement fixation. Results. Biopsy and serum studies confirmed a diagnosis of cus with SES-ANA in the patient reported. Skin biopsy showed lichen planus. The patient was treated with hydroxychloroquine with a favorable response. Serial SES-ANA titers did not parallel the disease activity. Among the substantive observations made from skin explants cultured in the serum of this patient was widespread fixation of C3 to the nuclei of basal cells. Conclusions. The case described herein extends the findings in cus to include lichenoid skin lesions. Records show that at least four of 11 cases of cus had skin lesions, whereas all had oral lesions. Stratified epithelium-specific antinuclear antibodies serve as the key marker of cus. Skin explants grown in the serum of this cus patient bind SES-ANA in tissue culture. Sections of explants fix complement. Titers of SES-ANA have been reported to parallel disease activity in one case, but not in the present case. Thus, there appears to be case-to-case variation. The treatment of choice for cus is hydroxychloroquine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1996.tb03000.x
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  • 9
    Electronic Resource
    Electronic Resource
    Tadeusz P. Chorzelski (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 28 (1989), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1989.tb04820.x
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  • 10
    Electronic Resource
    Electronic Resource
    HERPETIFORM PEMPHIGUS, A VARIABLE PATTERN OF PEMPHIGUS (1975)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 14 (1975), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : A patient with the clinical features of dermatitis herpetiformis and the histological features of pemphigus, subcorneal dermatosis and dermatitis herpetiformis did not respond to treatment with pyridine or sulfones. Systemic steroids and azothioprine were effective. Immunofluorescence studies demonstrated circulating pemphigus antibodies and IgG bound in vivo in the intercellular spaces of the epidermis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1975.tb00125.x
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