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  • 1
    Electronic Resource
    Electronic Resource
    A SIMPLIFIED ROUTE TO A KEY INTERMEDIATE IN THE TOTAL SYNTHESIS OF RESERPINE (1956)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 78 (1956), S. 2657-2657 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01592a102
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  • 2
    Electronic Resource
    Electronic Resource
    THE TOTAL SYNTHESIS OF RESERPINE (1956)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 78 (1956), S. 2023-2025 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01590a079
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  • 3
    Electronic Resource
    Electronic Resource
    Die Dünnschichtchromatographie der Aminosäuren im Urin (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 682-688 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Methods for thin-layer chromatography of urinary amino acids on commercially available procoated plates of micro-crystalline cellulose are presented. The urine is desalted by passing it through columns containing Amberlite CG 120 I. The amino acids are eluted by a solution of 5 per cent ammonia. The eluate is taken to dryness and dissolved in such an amount of water that 1 µl corresponds to 1 µg of creatinine. 1 µl is spotted to plates (10×10 cm) by micro pipets. Every urine is developed two-dimensionally by two solvent pairs. First pair: Ethanol-H2O (83:17), first direction, three times developed up to 8 cm, tert-Butanolmethylethylketone-NH3-diethylamine-H2O (35:35:10:0,4:20), second direction, once developed up to 8 cm. Second pair: n-Butanol-acetone-glacial acetic acid-H2O (35:35:10:20), first direction, phenol-formic acid (15 per cent) (250 g+83 ml), second direction, once developed up to 8 cm. Using these solvent pairs it is possible to separate most of the important urinary amino acids and diagnose or suspect most of the known metabolic disorders with a disturbed urinary excretion of amino acids. Phosphoethanolamine, S-sulphocysteine and taurine are lost by desalting the urine. Special problems of detecting and locating some amino acids are discussed.
    Notes: Zusammenfassung Es werden Methoden zur Dünnschichtchromatographie der Harnaminosäuren auf mikrokristalliner Cellulose angegeben. Vor der dünnschichtchromatographischen Trennung wird der Urin (Amberlite CG 120 I, H+-Form; Elution mit 5% igem NH3) entsalzt. Nach Einengen des Eluats zur Trockne und Lösung des Rückstandes in einer auf den Kreatiningehalt des Urins bezogenen Menge Wasser wird der Urin auf Cellulose-Fertigplatten der Fa. Merck AG. aufgetragen. Die Plattengröße beträgt 10×10 cm. Durch Verwendung von zwei Fließmittelpaaren ist es möglich, bei den meisten der bekannten Stoffwechselkrankheiten mit vermehrter Aminosäure-Ausscheidung eine Diagnose oder eine Verdachtsdiagnose zu stellen. Ausnahmen sind lediglich die Hypophosphatasie, der Sulfitoxydase-Mangel und die Taurinurie, da die bei diesen Störungen vermehrt ausgeschiedenen Aminosäuren Phosphoäthanolamin, S-Sulfo-l-cystein und Taurin bei der Entsalzung verloren gehen. Auf spezielle Probleme des Nachweises einzelner Aminosäuren wird eingegangen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01493814
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  • 4
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 54-56 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485595
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  • 5
    Electronic Resource
    Electronic Resource
    Veränderte Aktivitäten der Enzyme des Energiestoffwechsels in Thrombocyten von Patienten mit Lebercirrhose und Splenomegalie (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 526-533 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 1. The activities of 28 enzymes from different pathways of energy producing metabolism were measured in the isolated platelets of 17 normal persons and 15 patients with proven cirrhosis of the liver. 2. In mammalian tissues a constant proportion between the enzymes of the central segment of the glycolytic pathway (TIM, GAPDH, PGK, GPM, EN) has been described. This constant proportion has been demonstrated also in the platelets. The mitochondrially localized enzymes NAD-specific Isocitratdehydrogenase and Glycerophosphatoxidase have been measured for the first time in platelets with a high activity. 3. The platelets of patients with liver cirrhosis and splenomegaly following portal hypertension showed significant higher enzyme activities in all investigated pathways, mainly in the citric acid cycle. Functionally important could be the marked increase of the Mg++ activated ATPase, the unaltered activity of the Phosphofructokinase and a lowered activity of the Lactatdehydrogenase in these platelets. The patients with cirrhosis but without a large spleen had normal enzyme activities of the platelets. 4. One patient is described with cirrhosis without splenomegaly who had an elevation of nearly all measured enzymes by a factor 8 in his platelets. The LDH showed a decreased activity. 5. No enzyme defect in the platelets of cirrhotic patients as in thrombasthenia was found. Basing on our knowledge of the enzyme equipment of blood cells the conclusion is drawn that the platelets with higher enzyme content represent a young cell population. The pathogenesis is discussed with special reference to the role of the enlarged spleen.
    Notes: Zusammenfassung 1. Die Aktivitäten von 28 Enzymen aus verschiedenen Abschnitten des Energiestoffwechsels wurden in isolierten Thrombocyten von 17 gesunden Menschen und 15 Patienten mit gesicherter Lebercirrhose gemessen. 2. Die für Gewebe bekannte Proportionskonstanz der Enzymaktivitäten des zentralen Segmentes der Glykolyse (TIM, GAPDH, PGK, GPM und EN) findet sich auch in den Thrombocyten als Ordnungsprinzip. Die mitochondrial lokalisierten Enzyme NAD-spezifische Isocitratdehydrogenase und Glycerophosphatoxydase wurden erstmalig in Thrombocyten mit relativ hoher Aktivität nachgewiesen. 3. Die Plättchen von Patienten mit Lebercirrhose und Milzvergrößerung infolge portaler Hypertension zeigten signifikant erhöhte Enzymaktivitäten in allen untersuchten Stoffwechselwegen, insbesondere der mitochondrial lokalisierten Enzyme. Funktionell bedeutsam erscheinen der ausgeprägte Anstieg der Mg++-aktivierbaren ATPase, die gleichbleibende Aktivität der Fructose-6-Phosphatkinase und eine Verminderung der Lactatdehydrogenase. Bei der Patientengruppe mit Cirrhose ohne Milzvergrößerung lagen fast alle gemessenen Aktivitäten der Thrombocyten im Normbereich. 4. Es wird ein Patient mit Lebercirrhose ohne Milzvergrößerung beschrieben, dessen Thrombocyten um den Faktor 8 höhere Aktivitäten fast aller gemessenen Enzyme aufwiesen. Auch in diesen Plättchen zeigte die Lactatdehydrogenase eine Aktivitätsverminderung gegenüber der Norm. 5. Ein Enzymdefekt der Plättchen wie bei Thrombasthenie wurde bei Lebercirrhose nicht gefunden. Nach unseren Kenntnissen über die Enzymausstattung von Blutzellen handelt es sich bei den Thrombocyten mit höherer Enzymaktivität um eine jugendliche Zellpopulation. Die Pathogenese wird besonders hinsichtlich der Rolle der vergrößerten Milz diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747771
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  • 6
    Electronic Resource
    Electronic Resource
    3. Marburger Symposium, Herrenchiemsee (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 216-224 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02104152
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1963)
    Springer
    Journal of molecular medicine 41 (1963), S. 884-887 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01479026
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  • 8
    Electronic Resource
    Electronic Resource
    Coenzyme deficiency in atypical phenylketonuria (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 104-104 
    Details
    ISSN: 1432-1076
    Keywords: Coenzyme ; Atypical phenylketonuria ; Hyperphenylalaninaemia ; Malignant phenylketonuria ; Tetrahydrobiopterin ; Biopterin ; Neurotransmitters ; Dopamine ; Serotonine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441133
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  • 9
    Electronic Resource
    Electronic Resource
    Inter-laboratory quality control in neonatal screening for inborn errors of metabolism (1985)
    Springer
    European journal of pediatrics 144 (1985), S. 171-173 
    Details
    ISSN: 1432-1076
    Keywords: Inter-laboratory quality control ; Neonatal screening ; Inborn errors of metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Screening of neonates for inborn errors of metabolism has been carried out on a national level since 1969 in the Federal Republic of Germany. To raise the reliability of these routine investigations, we introduced an external quality control in March 1982. Every 2 months ten filter paper samples were sent to the screening centres in West Germany. Some of these samples have a normal and others a slightly raised content of phenylalanine, leucine, methionine and galactose. The success of this external quality control is appraised on the basis of the number of false negative results. In the course of time, screening centres in France, Israel, Italy, Japan, Switzerland, Taiwan, Turkey and Yugoslavia have also practicipated in these inter-laboratory quality controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451907
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  • 10
    Electronic Resource
    Electronic Resource
    Follow-up study of 16 years neonatal screening for inborn errors of metabolism in West Germany (1986)
    Springer
    European journal of pediatrics 145 (1986), S. 310-312 
    Details
    ISSN: 1432-1076
    Keywords: Neonatal screening in West Germany ; Inborn errors of metabolism ; Results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Capillary blood samples from almost one million neonates from Baden-Württemberg were investigated for inborn errors of metabolism between 1969 and 1984 in our screening centre. Besides 7 patients with maple syrup urine disease (MSUD), 3 with homocystinuria and 18 with galactosaemia, a follow-up of the positive screening results confirmed 94 patients with phenylketonuria (PKU) and 76 with non-PKU hyperphenylalaninaemia (non-PKU HPA). The incidence of PKU is 1: 10 000, and that of HPA in the wider sense (PKU and non-PKU HPA) as obtained by newborn screening before further classification at 6 months 1: 5532. For West Germany as a whole, the number of newly discovered cases with persistent hyperphenylalaninaemia was 1480 in the same period. The subdivision into PKU and non-PKU HPA is not yet possible from this figure. It is strongly suggested that the abnormal results of newborn screening for phenylalanine be designated as hyperphenylalaninaemia (in the wider sense) and that the terms “PKU” or “non-PKU HPA” be used only after further differentiation as carried out by us at the age of 6 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439408
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