Electronic Resource
Highley, M.S.
;
Samandas, N.
;
Ziras, N.
;
[et al.]
Morgan, M.M.
;
Hill, M.E.
;
Stein, R.
;
Barker, S.
;
Coleman, R.E.
;
Blake, P.R.
;
Morris, D.
;
Slevin, M.L.
;
Wiltshaw, E.
;
Harper, P.G.
Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts 02142, USA
:
Blackwell Science Inc.
International journal of gynecological cancer
6 (1996), S. 0
ISSN:
1525-1438
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Thirty-seven patients with advanced or recurrent cervical squamous cell carcinoma were treated with ifosfamide 1.5 g m−2 on days 1–5 (with mesna as a uroprotector), and bleomycin 30 mg on day 1, every 3 weeks. A partial response rate of 21% (95%CI: 6–36%) was obtained in patients who had not received prior chemotherapy, with a median duration of response of 5 months. No complete responses were seen. The median survival of all patients was 6 months. Nausea and vomiting, white cell suppression and encephalopathy were the main toxic effects. The results suggest that the addition of bleomycin to ifosfamide is not advantageous and increases toxicity, and that the interaction between these two agents is not contributory to the activity of the bleomycin, ifosfamide and cisplatin combination regimen (BIP). The potentially more severe toxicity of combination regimens must be considered when treating this group of patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1525-1438.1996.06040323.x
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