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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Osteosarcoma ; MR imaging ; Comparative studies ; Contrast enhancement ; Radionuclide imaging ; Chemotherapy ; Gadolinium ; Technetium 99m
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this work was to study and compare the usefulness of dynamic contrast-enhanced spin-echo MR imaging with high temporal resolution hydroxymethylene diphosphonate technetium-99 m skeletal angioscintigraphy in predicting the osteosarcoma histological response to neoadjuvant chemotherapy. Twelve patients with resectable osteosarcoma were prospectively monitored with dynamic MR imaging and skeletal scintigraphy before start of neoadjuvant chemotherapy, after two cycles of therapy and before surgery. Neoplasm signal intensity and activity intensity were plotted against time, and slopes were calculated for percentage increase over baseline values in the first minute. Stability and increase in slope values during or after chemotherapy were defined as a “radiological non-response”. Changes in slopes were compared with the “histological response” (Huvos grading). At midpoint of the chemotherapy, these two imaging modalities failed in predicting final histological response. After the completion of the chemotherapy, these imaging modalities allowed the prediction of histological response with the same accuracy (91 %). In this series, dynamic MR imaging and technetium skeletal scintigraphy provide similar results regarding the prediction of final histological response during neoadjuvant chemotherapy; these results cannot be used to modify the therapeutic protocol at midpoint of chemotherapy; these imaging tools predict accurately the histological response at the end of chemotherapy. These latter results may permit anticipation of the adjuvant chemotherapy strategy during decalcification procedures in resected osteosarcoma and thus to monitor chemotherapy in non-surgical osteosarcoma.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'analyse du dossier angiographique de 50 lésions expansives sous-tentorielles, revu à l'aide du soustractuer électronique, a permis de mettre en évidence l'existence d'une imprégnation tumorale dans 32% des cas. — La présence de celle-ci, qu'elle intéresse l'ensemble de la lésion (7 cas), ou qu'elle sait partielle (9 cas), apporte des renseignements d'ordre topographique et histopathologique, en particulier en ce qui concerne les méningiomes (5 imprégnations sur 11), et les hémangiomes (7 cas sur 7). — La situation de la lésion à l'intérieur de la Fosse cérébrale postérieure intervient également: l'angle pontocérébelleux étant plus rarement le siège d'une imprégnation que la loge cérébelleuse ou la ligne médiane.
    Abstract: Zusammenfassung Die Vascularisation von raumfordernden Prozessen im Bereich der hinteren Schädelgrube konnte mittels der Brachialisangiographie in 32% der Fälle demonstriert werden. Es wird auf die einzelnen Formen der Tumoranfärbungen bei den verschiedenen Geschwülsten eingegangen. Die topograpische Lage der Hirngeschwulst wird mit der Tumor-Anfärbung verglichen.
    Notes: Summary Examination of angiographic films of 50 sub-tentorial space occupying lesions by means of electronic subtraction demonstrated a tumour circulation in 32% of cases. — The existance of a complete (7 cases) or partial (9 cases) tumour circulation provides topographical and histopathological information, especially in cases of meningioma (5 circulations demonstrated outof 11 cases) and haemangioma (7 circulations demonstrated out of 7 cases). — The position of the tumour within the posterior fossa is also related to the incidence of visualized pathological tumour circulations: a circulation is more often demonstrated in cerebellar and centrally placed tumours than in tumours of the cerebello-pontine angle.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Skeletal radiology 22 (1993), S. 457-459 
    ISSN: 1432-2161
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2161
    Keywords: Key words Newborn ; Lumbar spine ; Bone mineral density ; Quantitative computed tomography ; Dual-energy X-ray absorptiometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. To assess the true mineral density (BMD, in g/cm3) of the lumbar spine in newborns. Design and patients. A post-mortem analysis of five infants with gestational ages ranging from 35 to 40 weeks, and birth weights from 2765 to 3200 g, was conducted using dual-energy quantitative computed tomography (QCT; Siemens Somatom DR). A 2 or 4 mm thick slice was obtained for each lumbar vertebra from L1 to L4. The density measured in these vertebrae was corrected by reference to a solid phantom (Osteo-CT) measured simultaneously. A three-dimensional image of the spine (Elscint CT Twin), as well as a photomicrograph of histological preparation from L2 vertebra, were also obtained in another term baby for comparison with the CT results. Results and conclusions. In the range of values studied, the vertebral densities were not dependent on birth weight. BMD values measured in L2, L3 and L4 were not significantly different, but were 10% lower than in L1 in four of five infants. The spatial resolution of the QCT protocol used (0.4 mm) did not permit the differentiation of trabecular and cortical bone, and the vertebral bodies appeared very homogeneous and dense, with a mean density value of 210±30 mg Ca/cm3, which is 2.5 times higher than the mean maximum value found in young normal adults. These preliminary results highlight the potential of QCT in neonatology. Special protocols will, however, need to be developed for in vivo measurements in this particular paediatric field.
    Type of Medium: Electronic Resource
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