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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 9 (1976), S. 307-314 
    ISSN: 1432-1041
    Keywords: Absorption ; man ; β-methyl-digoxin ; serum concentration ; urinary excretion ; radio-immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Single doses of β-methyl-digoxin 0.4 mg were given to groups of 17 – 18 healthy volunteers as an intravenous infusion lasting 2 hours, or orally as Lanitop Liquidum® or Lanitop® tablets. The serum glycoside concentration and urinary glycoside excretion were measured over 8 and 32 h. The absolute bioavailability from the oral preparations in comparison with the infusion was lower for the first 8 h than for the entire 32 h of the investigation; the relative bioavailability from tablets was the same as from the solution for both periods. For both periods the area under the serum concentration/time curve and the urinary glycoside excretion were significantly lower after administration of the tablets than after intravenous infusion. Taking the average of both parameters, the absolute bioavailability of β-methyl-digoxin was about 80% from the solution and about 70% from the tablets. In 18 patients undergoing intravenous or oral therapy with β-methyl-digoxin steady state glycoside concentrations were compared in a cross-over study of intravenous maintenance therapy with Lanitop® ampoules or oral treatment with Lanitop® tablets. For a standard daily dose of 0.2 mg β-methyl-digoxin the serum concentrations were 1.35±0.10 ng/ml during both intravenous and oral administration. The intra-individual variation in glycoside concentration after changing from intravenous to oral maintenance therapy, or vice versa, was about the same as during continued intravenous or oral administration. It is concluded that the rate of rise of serum concentration after a single dose may be a useful indicator of the rate of absorption, but that the area under the serum concentration/time curve and the urinary glycoside excretion up to 32 h are unsuitable for determining equivalent doses of different formulations or routes of administration of digitalis glycosides.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 115 (1993), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: A methodology to determine quantitatively the dimensionality of the dominant conducting structures and the resolution of the structural parameters in magnetotelluric data is presented. In addition, the method recovers the regional impedance responses when the regional structure can be characterized, at least approximately, as 1- or 2-D. The methodology is based upon three general models of the MT tensor, each of which has a distinct parameterization and physical interpretation. A weighted statistical residual describes quantitatively the fit of the model response to the data within the scatter of the measured data and hence permits: (1) tests of dimensionality, (2) determination of the appropriate strike angle, and (3) recovery of the regional responses.The method has been tested extensively with synthetic data and proven to be successful. These synthetic studies give insight into the different physical parameterizations and the stability of the parameters determined. We describe and illustrate some of these synthetic studies. With field data, the methodology is not always as straightforward, but its application to a great many sites has proven valuable. Data from two closely spaced sites, which are both affected by strong but very different 3-D effects, are analysed to illustrate the geological significance of the results. The analyses reveal and recover regional responses within the data which indicate the presence of electrical anisotropy located deep in the crust and upper mantle. Analyses of the entire data set, of which these two form a part, confirm this finding.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 111 (1992), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: The Earth is a causal system to electromagnetic excitation so that the real and imaginary parts of the electromagnetic field satisfy a dispersion relation. If the earth response to controlled-source electromagnetic excitation is also minimum phase, then the phase of the measured fields relative to the source current can be estimated from amplitude measurements. Although this procedure does not yield additional information about the conductivity structure of the Earth, it does facilitate data analysis procedures such as stripping powerline responses, spatial filtering and layer stripping. When the phase is actually measured, application of the dispersion relation provides a self-consistency test on measurements to detect strong noise contributions, active source contamination, numerical difficulties, etc., and thus can be used for data adaptive stacking of power spectra in time series reprocessing.Numerical studies and examples using field data indicate that the phase estimated from a causal dispersion relation can be of comparable quality to that obtained from direct measurement. Synthetic responses from 1-D models and 3-D thin-sheet models demonstrate a typical accuracy of within 1° for the estimated phase, which is similar to the phase accuracy attainable from field measurements. The limitations of the technique are the requirements for broad bandwidth amplitude data, and the lack of a general proof that the electromagnetic response of an arbitrary earth structure is minimum phase.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 121 (1995), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: An integral equation is derived to represent the electromagnetic response of line conductors buried below the surface of a horizontally stratified earth. By permitting several finite-length line conductors of arbitrary topology, this representation is free of the limitations imposed by analytic solutions. The integral equation is formulated in terms of excess electric current (scattering current) flowing along the line conductor and is solved numerically by dividing the line conductor into many small segments. In general, the excess electric current is controlled by both the internal and external impedance of the line conductor. The internal impedance is the longitudinal resistance of the line conductor. The external impedance is caused by galvanic and inductive coupling between the line conductor and its local environment. The galvanic resistance to current channelling is spatially variable with a minimum in the centre of a uniform line conductor and is determined by conductor geometry and the host conductivity structure. The inductive external impedance is proportional to frequency and quadrature dominant. It is a function of line-conductor geometry, cross-section and burial environment. The inductive impedance effectively reduces the spatial dependence of the external impedance at high frequency by presenting a large reactance (which is uniform at all points along the conductor) to the exciting electric field.Within the quasi-static limit (i.e. where displacement current can be neglected), electromagnetic excitation by either horizontal electric or vertical magnetic dipoles produces a constant primary electric field at high frequencies (far field). The excess electric current in the line conductor will always be inversely proportional to frequency for these types of sources at sufficiently high frequencies where the inductive external impedance is dominant. Horizontal magnetic dipole and vertical electric dipole sources generate primary electric fields that are proportional to the square root of frequency in the high-frequency limit of the quasi-static domain and the excess electric current excited by such sources will decrease as the inverse of the square root of frequency.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Surface Science Letters 114 (1982), S. A60 
    ISSN: 0167-2584
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Surface Science Letters 122 (1982), S. L608-L612 
    ISSN: 0167-2584
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Surface Science 122 (1982), S. L608-L612 
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Surface Science 114 (1982), S. 109-117 
    ISSN: 0039-6028
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the immune-stimulating properties of 2-(2-cyanaziridinyl-[1]-)-2-(2-carbamoylaziridinyl-[1]-) propane (INN azimexon) a randomized double-blind study was performed in 30 cancer patients with different solid tumors. A group of 15 patients received 300 mg azimexon PO over a 7-day period, while 15 other patients received a placebo. We could not demonstrate an increase of total or active T lymphocytes, and the 3H-thymidine uptake of isolated lymphocytes with or without PHA stimulation was not increased when tested 3, 7, 14, and 21 days after the beginning of therapy. The serum concentration of IgM showed a slight but not significant increase, while IgG, IgA, C3, and C4 levels remained unchanged. The major side-effect was a significant decrease of hemoglobin and red blood cell count after azimexon administration, which was even more pronounced in four patients given 900 mg azimexon.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Patients with different types of cancer received treatment PO or IV with the new immunostimulating compound, 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, BM 12.531 (Prop. INN azimexon). After IV administration of 200 mg on 5 consecutive days or oral administration of 300 mg on 7 consecutive days a significant increase in the percentage of active T lymphocytes was seen. After in vitro incubation of different concentrations of BM 12.531 with blood from healthy donors there was a significant increase in the percentage of active T lymphocytes. No clear influence of BM 12.531 on the lymphocyte transformation caused by various concentrations of PHA could demonstrated because of the scatter. No side effects attributable to treatment with BM 12.531 were found, so that BM 12.531 is a good candidate for clinical trials.
    Type of Medium: Electronic Resource
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